Understanding the physiological and functional consequences of menopause: The PROSALMEN study
Background and aims: Women live longer and are more often affected by disability and poor health than men. The mechanism underlying this sex-related “mortality-morbidity” paradox is still unclear but it has been suggested that the physiological and functional changes occurring during the menopausal transition play an important role. The aim of PROSALMEN (PROgetto SALute MENopausa: Health in Menopause Project) is to study in great detail how these changes affect the integrity and function of the physiologic subsystems that are relevant to the maintenance of an active and healthy life-style during the aging process. Methods: PROSALMEN is a cross-sectional comparison of age-matched pre- and post-menopausal women. Thirty post-m enopausal women, aged 48–58 years, were enrolled in the study together with 30 age-matched pre-menopausal controls. A number of clinical, biological and functional parameters were collected assessing the integrity and level of function of the physiological subsystems that are important for mobility. Furthermore, we collected information on risk factors, medical conditions and symptoms that frequently develop or become clinically evident after menopause, including the most important elements of the classical post-m enopausal syndrome. Conclusions: This rich dataset will be used to start dissecting the causal pathway leading from menopause to damages in the musculoskeletal system and, in turn, to reduced physical function. The final goal is to understand how and to what extent changes in health behavior and pharmacological treatments in addition to hormone replacement therapy (HRT) may counteract these processes.
KeywordsAging menopause older women physical performance prevention PROSALMEN Study
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- 1.Guralnik JM, Balfour JL, Volpato S. The ratio of older women to men: historical perspectives and cross-national comparisons. Aging Clin Exp Res 2000; 12: 65–76.Google Scholar
- 4.Ferrucci L, Benvenuti E, Bartali B, et al. Preventive health care for older women: life-style recommendations and new directions. Aging Clin Exp Res 2000; 12: 113–31.Google Scholar
- 5.Hazzard WH. The sex differential in longevity. In Hazzard WR, Bierman EL, Blass JP, Ettinger WH, Halter JB, eds. Principles of Geriatric Medicine and Gerontology. New York: McGraw-Hill, Inc. 1994: 37–47.Google Scholar
- 7.Giampaoli S. Epidemiology of major age-related diseases in women compared to men. Aging Clin Exp Res 2000; 12: 93–105.Google Scholar
- 8.Ferrucci L, Guralnik JM, Simonsick E, Salive ME, Corti C, Langlois J. Progressive versus catastrophic disability: a longitudinal view of the disablement process. J Gerontol 1996; 51: M123–M130.Google Scholar
- 13.Evans W. Symposium: Sarcopenia: Diagnosis and Mechanisms. Functional and Metabolic Consequences of Sarcopenia. J Nutr 1997; 127: 998S–1003S.Google Scholar
- 15.Meschia M, Pansini F, Modena AB, et al. Determinants of age at menopause in Italy: results from a large cross-sectional study. ICARUS Study Group. Italian Climacteric Research Group Study. Maturitas 2000; 34: 119–25.Google Scholar
- 17.Bandinelli S, Benvenuti E, Del Lungo I, et al. Measuring muscular strength of the lower limbs by hand-held dynamometer: a standard protocol. Aging Clin Exp Res 1999; 11: 287–93.Google Scholar
- 18.Bassey EJ, Short AH. New method for measuring power output in a single leg extension: feasibility, reliability and validity. Eur J ApplPhysiol 1990; 60: 385–90.Google Scholar
- 20.Miller PJ. Assessment of Joint Motion. Measurement in physical therapy. New York: Churchill Livingstone, 1985: 103–36.Google Scholar
- 26.Kehayias J, Heymsfield S. Symposium: Sarcopenia: Diagnosis and Mechanisms. Introduction. J Nutr 1997; 127: 989S–1015S.Google Scholar
- 28.Wasserman JE, Hansen JE, Sue DY, Whipp BJ, Csaburi R. Principles of Exercise Testing and Interpretation, ed. 2. Philadelphia: Lea and Febiger, 1994.Google Scholar