Aging Clinical and Experimental Research

, Volume 7, Issue 2, pp 136–139 | Cite as

Is late- life caloric restriction beneficial?

  • Ruth D. Lipman
  • D. E. Smith
  • R. T. Bronson
  • J. Blumberg
Original Article

Abstract

Caloric restriction initiated in young mice and rats results in increases in mean and median life span. When caloric restriction is implemented in older animals, an increase in life span is still observed; however, the magnitude of the increase is not as great as that observed in animals calorie restricted since they were young. Here we report the results of a pilot study in which caloric restriction was initiated in mature, older rats. Survival rates and terminal pathology were characterized and compared between a cohort of 17 continually ad libitum fed Long Evans rats and a cohort of 18 Long Evans rats, which were gradually introduced to 33% restriction in diet consumption at 18 months of age. No difference in the median life span was observed between the two groups. The data suggest there may be a level of maturity, or a stage in the aging process, after which caloric restriction no longer increases longevity. (Aging Clin. Exp. Res. 7: 136 -139, 1995 )

Keywords

Aging caloric restriction mortality rats 

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Copyright information

© Springer Internal Publishing Switzerland 1995

Authors and Affiliations

  • Ruth D. Lipman
    • 1
  • D. E. Smith
    • 1
  • R. T. Bronson
    • 1
  • J. Blumberg
    • 1
  1. 1.USDA Human Nutrition Research Center on Aging at Tufts UniversityBostonUSA

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