Aging Clinical and Experimental Research

, Volume 7, Issue 2, pp 75–76

Aging, zinc and cell-mediated immune response

  • Cristina Fortes


  1. 1.
    WHO: The uses of epidemiology in the study of the elderly. Technical Report series 706, World Health Organization, Geneva, 1984.Google Scholar
  2. 2.
    Chandra R.K.: Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 340: 1124–1127, 1992.PubMedCrossRefGoogle Scholar
  3. 3.
    Penn N.D., Purkins L., Kelleher J., Heatley R.V., Taylor-Mascie B.H., Belfield P.W.: The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: A randomized controlled trial. Age Ageing 20: 169–174, 1991.PubMedCrossRefGoogle Scholar
  4. 4.
    Chavance M., Herbeth B., Lemoine A., Zhu B.P.: Does multivitamin supplementation prevent infections in healthy elderly subjects? A controlled trial. Int. J. Vit. Nutr. Res. 63: 11–16, 1992.Google Scholar
  5. 5.
    Mills C.F.: Zinc in human biology. Springer-Verlag, London, 1988.Google Scholar
  6. 6.
    Fraker P.J., King L.E., Garvy B.A., Medina C.A.: The immunopathology of zinc deficiency in humans and rodents — a possible role for programmed cell death. In: Klurfeld D. (Ed.), Human Nutrition- A comprehensive treatise, Vol. 8: Nutrition and Immunology. Plenum Press, New York, 1993.Google Scholar
  7. 7.
    Bray T.M., Bettger W.: The physiological role of zinc as an antioxidant. Free Rad. Biol. Med. 8: 281–291, 1990.PubMedCrossRefGoogle Scholar
  8. 8.
    Dardenne M., Boukaiba N., Gagnerault M.C., Delarche F.H., Chappuis P., Lemonnier D., Savino W.: Restoration of the thymus in aging mice by in vivo zinc supplementation. J. Immunol. Immunopathol. 66: 127–135, 1993.CrossRefGoogle Scholar
  9. 9.
    Fox R.A.: Immunology of ageing. In: Blockenhurst C.J. (Ed.), Textbook of Medicine and Gerontology. Churchill Livingstone, London, 1985.Google Scholar
  10. 10.
    Whaine S.J., Rhyne R.L., Garry P.J., Goodwin J.S.: Cell-mediated immunity as predictor of morbidity and mortality in subjects over 60. J. Gerontol. 45: 45–48, 1990.CrossRefGoogle Scholar
  11. 11.
    Roberts-Thompson I.C., Whittingham S., Youngchaiyud U., Mackay I.R.: Aging, immune response, and mortality. Lancet 2: 368–370, 1974.CrossRefGoogle Scholar
  12. 12.
    Makinodan T., James S.J., Inamizu T., Chang M.: Immunologic basis for susceptibility to infection in the aged. Gerontology 30: 279–289, 1984.PubMedCrossRefGoogle Scholar
  13. 13.
    Mackall C.L., Fleisher T.A., Brown M.R., Andrich M.P., Chen C.C., Fenerstein I.M., Horowitz M.E., Magrath I.T., Shad A.T., Steinberg S.M., Wexler L.H., Gress R.E: Age, thymopoiesis and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N. Engt. J. Med. 332: 143–149, 1995.CrossRefGoogle Scholar
  14. 14.
    Bogden D.J., Oleske M.J., Munves M.E., Lovenhar A.M., Bruening S.K., Kemp W.F., Holding J.K., Denny N.T., Lauria B.D.: Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. Am. J. Clin. Nutr. 46: 101–109, 1987.PubMedGoogle Scholar
  15. 15.
    Bunker V.W., Clayton B.E.: Research Review: Studies in the nutrition of elderly people with particular reference to essential trace elements. Age Ageing 18: 422–429, 1989.PubMedCrossRefGoogle Scholar
  16. 16.
    Duchateau J., Delepesse G., Verecke P.: The beneficial effects of oral zinc supplementation on the immune response of old people. Am. J. Med. 70: 101–104, 1981.CrossRefGoogle Scholar
  17. 17.
    Boukaiba N., Flament C., Acher S., Chappuis P., Piau A., Fusselier M., Dardenne M., Lemonnier D.A.: A physiological amount of zinc supplementation: effects on nutritional, lipid, and thymic status in an elderly population. Am. J. Clin. Nutr. 57: 566–572, 1993.PubMedGoogle Scholar

Copyright information

© Springer Internal Publishing Switzerland 1995

Authors and Affiliations

  • Cristina Fortes
    • 1
  1. 1.Osservatorio EpidemiologicoRegione LazioRomaItaly

Personalised recommendations