Aging Clinical and Experimental Research

, Volume 4, Issue 3, pp 255–257 | Cite as

Relationship between the immune system and frailty: Pathogenesis of immune deficiency in HIV infection and aging

  • Joseph B. Margolick
  • R. K. Chopra
Symposiums Report Conference on the physiologic basis of frailty April 28, 1992, Baltimore, Maryland, U.S.A.

En]Keywords

Aging AIDS immune system T lymphocytes 

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References

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    Finkelstein M.S.: Aging immunocytes and immunity. Clin. Geriatric Med. 1: 899–911, 1985.Google Scholar
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    Chopra R.K.: Mechanisms of impaired T cell function in the elderly. Review of Biological Research in Aging 4: 83–104, 1990.Google Scholar
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    Margolick J.B., Volkman D.J., Lane H.C., Fauci A.S.: Clonal analysis of T lymphocytes in the acquired immunodeficiency syndrome: Evidence for an abnormality affecting individual helper and suppressor T cells. J. Clin. Invest. 76: 709–715, 1985.PubMedCrossRefGoogle Scholar
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    Donnenberg A.D., Margolick J.B., Polk B.F.: Limiting dilution analysis in vivo-activated (IL-2 responsive) peripheral blood lymphocytes in HIV-1-infected subjects. Clin. Immunol. Immunopathol. 51: 91–98, 1989.PubMedCrossRefGoogle Scholar
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    Pantaleo G., Koenig S., Baseler M., Lane H.C., Fauci A.S.: Defective clonogenic potential of CD8+ T lymphocytes in patients with AIDS. J. Immunol 144: 1696–1704, 1990.PubMedGoogle Scholar

Copyright information

© Editrice Kurtis s.r.l. 1992

Authors and Affiliations

  • Joseph B. Margolick
    • 1
  • R. K. Chopra
    • 1
  1. 1.Department of Environmental Health SciencesJohns Hopkins University, School of Public HealthBaltimoreUSA

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