Advertisement

European Archives of Paediatric Dentistry

, Volume 12, Issue 1, pp 46–50 | Cite as

Case Report: Hypophosphatemic rickets and aggressive periodontitis: a review of the role of dentine matrix protein 1 in the pathogenesis

  • S. H. S. Al-JundiEmail author
  • M. M. Hammad
  • I. Dabous
Article

Abstract

BACKGROUND: The association between hypophosphatemic rickets (HR) and excessive periodontal breakdown was reported in mice models of HR. In humans, this is the first report of a possible association between HR and periodontal breakdown. CASE REPORT: The following presents a report of a case of a 15 year-old child diagnosed with HR at age 9 years, with atypical premature spontaneous loss of teeth due to periodontal defects in the absence of dental abscesses, dental caries, or trauma. The case is discussed in the context of relevant literature; the possible role of dentine matrix protein 1 in the aetiology of such periodontal defects in patients with HR is also discussed. CONCLUSION: Spontaneous loss of teeth in the absence of abscess formation is not one of the reported features of HR, however, this report may alert clinicians of the possibility of such association especially in the autosomal recessive type. Further case reports and more elaborate genetic and molecular testing is needed to verify this especially in late diagnosis cases.

Key words

hypophosphatemia rickets dentine matrix protein periodontitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Armitage GC. Development of a Classification System for Periodontal Diseases and Conditions. Ann Periodontol 1999; 4:1–6.PubMedCrossRefGoogle Scholar
  2. Assadi F. Hypophosphatemia An Evidence-based Problem-Solving Approach to Clinical Cases. Iranian Journal of Kidney Diseases 2010; 4Google Scholar
  3. Farach-Carson MC, Nemere I. Membrane receptors for vitamin D steroid hormones: potential new drug targets. Curr Drug Targets 2003; 4: 67–76.PubMedCrossRefGoogle Scholar
  4. Feng JQ, Huang H, Lu Y, et al. The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res 2003; 82: 776–780.PubMedCrossRefGoogle Scholar
  5. Feng JQ, Ward LM, Liu S, et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 2006; 38:1310–1315.PubMedCrossRefGoogle Scholar
  6. Goodman JR, Gelbier MJ, Bennett JH, Winter GB. Dental problems associated with hypophosphataemic vitamin D resistant rickets. Int J Pediatr Dent 1998; 8:19–28.CrossRefGoogle Scholar
  7. Ji-mei SU, Yun LI, Xiao-wei YE, Zhi-fang WU. Oral findings of hypophosphatemic vitamin D-resistant rickets: report of two cases Chin Med J 2007; 120:1468–1470Google Scholar
  8. Lorenz-Depiereux B, Bastepe M, Benet-Pagès A, et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of Phosphate homeostasis. Nat Genet 2006; 38: 1248–1250.PubMedCrossRefGoogle Scholar
  9. Lorenz-Depiereux B, Schnabel D, Tiosano D, Häusler G, Strom T. Loss-of-Function ENPP1 Mutations Cause Both Generalized Arterial Calcification of Infancy and Autosomal-Recessive Hypophosphatemic Rickets. Am J Hum Genet. 2010 February 12; 86(2): 267–272PubMedCrossRefGoogle Scholar
  10. Negri AL. Hereditary hypophosphatemias: New genes in the bone-kidney axis. Journal Asian Pacific Society of Nephrology. 2007; 12:317–320.Google Scholar
  11. Qin C, Baba O, Butler WT. Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Crit Rev Oral Biol Med. 2004; 15:126–36PubMedCrossRefGoogle Scholar
  12. Rowe OS. The molecular background to hypophosphatemic rickets. Arch Dis Child 2000; 83:192–4.PubMedCrossRefGoogle Scholar
  13. Rowe OS, de Zoysa PA, Dong R, et al. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics. 2000; 67: 54–68.PubMedCrossRefGoogle Scholar
  14. Seow WK, Latham SC. The spectrum of dental manifestations in vitamin Dresistant rickets: implications for management. Pediatr Dent 1986; 8: 245–50.PubMedGoogle Scholar
  15. Whyte MP, Thakke RV. Rickets and osteomalacia. The Medicine Publishing Company Ltd 2005; 33:70–74.Google Scholar
  16. Ye L, Zhang S, Ke H, Bonewald LF, Feng JQ. Periodontal Breakdown in the Dmp1 Null Mouse Model of Hypophosphatemic Rickets. J Dent Res. 2008; 87: 624–9.PubMedCrossRefGoogle Scholar

Copyright information

© European Archives of Paediatric Dentistry 2011

Authors and Affiliations

  1. 1.Dept. Preventive DentistryJordan University of Science and TechnologyIrbidJordan
  2. 2.Private specialist practiceAmmanJordan

Personalised recommendations