European Archives of Paediatric Dentistry

, Volume 8, Issue 4, pp 195–200 | Cite as

Enamel mineral concentration in diabetic rodents

  • M. AtarEmail author
  • G. R. Davis
  • P. Verry
  • F. S. L. Wong


Aim: This was to assess the mineral composition and 3-D structure of enamel and bone in the teeth and skulls of diabetic rodents. Methods: Three-dimensional images of the skull were reconstructed using x-ray microtomography (XMT) computer-generated false colour to highlight different levels of mineralization in bone and enamel. Results: These showed that diabetic rodents exhibited more wear in their teeth. Deformities were observed in the alveolar process of the mandible and maxilla. Regions of extensive hypomineralization were found in the calvarial bone of skulls. The maximum mineral concentrations and the time constants for diabetic rodents were similar to the controls. The diabetic mice appeared to have random regions of hypomineralization and one diabetic rat had areas of hypoplasia in the mandibular incisors. Conclusions: Diabetes may have a profound detrimental influence on the function of ameloblasts in laying down enamel.


Diabetes mellitus enamel bone dental hard tissues mineral concentration x-ray microtomography 


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Copyright information

© European Archives of Paediatric Dentistry 2007

Authors and Affiliations

  • M. Atar
    • 1
    Email author
  • G. R. Davis
    • 2
  • P. Verry
    • 3
  • F. S. L. Wong
    • 1
  1. 1.Dept. Oral Growth and Development Section of Paediatric Dentistry, Barts and The LondonQueen Mary University of London, School of Medicine and DentistryWhitechapelEngland
  2. 2.Biophysics in Relation to Dentistry, Barts and The LondonQueen Mary University of London, School of Medicine and DentistryLondonEngland
  3. 3.Hoffmann-La Roche Ltd., Pharmaceuticals DivisionMetabolic Preclinical Research, Vascular and Metabolic DiseasesBaselSwitzerland

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