Aim: The aim of the study was to monitor the pattern of release and salivary xylitol concentrations during sucking of a slow-release pacifier used to deliver a novel food supplement. Methods: The food supplement tablet contained 300 mg xylitol and 0.5 × 1010 colony-forming units of Bifidobacterium lactis Bb-12 (Bb-12). The reference tablet contained 300 mg xylitol and was used by 10 adults (mean age 32 years) in the study. Whole saliva samples were collected with 2.5 min intervals during pacifier sucking. The salivary xylitol concentrations were determined using an enzyme assay kit. Results: All subjects showed salivary xylitol concentrations exceeding 1 % at least at one collection point. The xylitol and xylitol-Bb-12 tablets showed similar dissolving with no clear concentration peaks (comparison of saliva collection times; p = 0.139). Conclusion: Xylitol released from the food supplement, delivered with the novel pacifier, may result in salivary xylitol concentrations high enough to inhibit mutans streptococci in vivo.
xylitol pacifier saliva
This is a preview of subscription content, log in to check access.
Aaltonen AS, Suhonen JT, Tenovuo J, Inkilä-Saari I. Efficacy of a slow-release device containing fluoride, xylitol and sorbitol in preventing infant caries. Acta Odontol Scand 2000;58: 285–292.PubMedCrossRefGoogle Scholar
Holgerson PF, Stecksen-Blicks C, Sjöström I, Öberg M, Twetman S. Xylitol concentration in saliva and dental plaque after use of various xylitol-containing products. Caries Res 2006; 40(5): 393–397.CrossRefGoogle Scholar
Kalliomäki M, Salminen S, Arvilommi H, et al.. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357:1076–1079.PubMedCrossRefGoogle Scholar
Kontiokari T, Uhari M, Koskela M. Effect on xylitol on growth of nasopharyngeal bacteria in vitro. Antimicrob Agents and Chemother 1995;39:1820–1823.CrossRefGoogle Scholar
Milgrom P, Ly KA, Roberts MC, et al. Mutans streptococci dose response to xylitol chewing gum. J Dent Res 2006;85(2):177–181.PubMedCrossRefGoogle Scholar
Saavedra JM, Abi-Hanna A, Moore N, Yolken RH. Long-term consumption of infant formulas containing live probiotic bacteria; tolerance and safety. Am J Clin Nutr 2004;79: 261–267.PubMedGoogle Scholar
Söderling E, Isokangas P, Pienihäkkinen K, Tenovuo J. Influence of maternal xylitol consumption on acquisition of mutans streptococci by infants. J Dent Res 2000;79:882–887.PubMedCrossRefGoogle Scholar
Taipale T, Pienihäkkinen K, Alanen P, Jokela J, Söderling E. Dissolution of xylitol from a food supplement administered with a pacifier. J Dent Res 2005;84:34 (Spec Iss C).Google Scholar
Tapiainen T, Renko M, Kontiokari T, Uhari M. Xylitol concentrations in the saliva of children after chewing xylitol gum or consuming a xylitol mixture. Eur J Microbiol Infect Dis 2002;21: 53–55.CrossRefGoogle Scholar
Vadeboncoeur C, Trahan L, Mouton C, Mayrand D. Effect of xylitol on the growth and glycolysis of acidogenic oral bacteria. J Dent Res 1983;62: 882–884.PubMedCrossRefGoogle Scholar