Effects of different amounts of a low fluoride toothpaste on primary enamel lesion progression: a preliminary study using in vitro pH-cycling system

  • A. ItthagarunEmail author
  • P. Thaveesangpanich
  • N. M. King
  • F. R. Tay
  • J. S. Wefel


Aims: To evaluate and compare the efficacy of pea and halfpea portions of child formula fluoride (500ppm) toothpaste on artificially created enamel lesions in primary teeth. Methods: Sound primary incisors were painted with nail varnish, leaving a 1 mm wide window and then placed in a demineralising solution for 96 h to produce artificial carious lesions 60–100μm deep. The teeth were longitudinally sectioned (100μm thick) and divided into 3 groups. Group A: treated with a pea-sized portion of a non-fluoride containing toothpaste (1:3, toothpaste: deionized water), while Groups B and C were treated with half-pea-sized and pea-sized portions of a 500 ppm fluoride containing toothpaste, respectively. The pH-cycling model was utilized for 7 days. Results: Groups A and B lesions increased in depth by 60% while those in Group C increased by 19%. The mineral content of the surface zone decreased significantly in Groups A and B but not in Group C. Conclusion: Reduction of the amount of fluoride toothpaste to less than a pea-size in order to minimize the risk of fluorosis should be undertaken with caution because it may compromise the cariostatic effects of the toothpaste.

Key words

fluoride toothpaste enamel lesion pH cycling model 


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Copyright information

© European Archives of Paediatric Dentistry 2007

Authors and Affiliations

  • A. Itthagarun
    • 1
    Email author
  • P. Thaveesangpanich
    • 1
  • N. M. King
    • 1
  • F. R. Tay
    • 1
  • J. S. Wefel
    • 2
  1. 1.Paediatric Dentistry, Faculty of DentistryThe University of Hong KongPokfulamHong Kong SAR
  2. 2.Dows Institute for Dental Research, College of DentistryUniversity of IowaIowaUSA

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