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Acute Effects of an Orally Active Dopamine Prodrug (TA-870) on Systemic Haemodynamics and Renal Functions

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Summary

The acute haemodynamic and renal effects of TA-870, an orally active dopamine prodrug, were investigated in 30 patients with coronary artery disease. Haemodynamic and renal effects of TA-870 were determined following Swan-Ganz catheterisation and clearance tests, respectively, for 4 hours after the administration of 750, 1050 and 1500mg doses.

TA-870 significantly increased cardiac index (6 to 13%) and stroke volume index (8 to 11%) but significantly decreased systemic vascular resistance (8 to 15%) 1 to 2 hours after administration, while causing no significant change in heart rate, mean blood pressure, right atrial pressure, mean pulmonary artery pressure, left ventricular stroke work index, total pulmonary resistance and oxygen consumption. TA-870 significantly increased urine volume (39 to 51%), renal blood flow (27 to 93%), glomerular filtration rate (18 to 52%) and urinary electrolyte excretion (Na, 27 to 214%; Cl, 26 to 259%).

The systemic haemodynamic and renal effects of TA-870 were similar to those obtained by the continuous infusion of low dose dopamine. There were no adverse effects at any dose levels tested. Thus, orally administered TA-870 warrants further investigation as a practical alternative to low-dose dopamine infusion.

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Correspondence to Dr Susumu Nishizaki.

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Nishizaki, S., Fukuma, A., Ogurusu, C. et al. Acute Effects of an Orally Active Dopamine Prodrug (TA-870) on Systemic Haemodynamics and Renal Functions. Drug Invest. 3, 118–125 (1991). https://doi.org/10.1007/BF03259551

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Keywords

  • Dopamine
  • Cardiac Index
  • Pulmonary Artery Pressure
  • Renal Blood Flow
  • Pulmonary Capillary Wedge Pressure