Immune Function in Chronic Fatigue Syndrome and Depression
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Considerable data now support the concept that patients with chronic fatigue syndrome and those with the melancholic subtype of major depression frequently have alterations in measures of immune function in vitro and in vivo. Although chronic fatigue syndrome and major depression have significant clinical similarity, the patterns of immunological and neuroendocrine alterations seen in the 2 disorders are dissimilar. The immunological changes provide tantalising clues to the pathophysiology of these disorders but, as yet, do not have clear implications for therapy.
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