Clinical Immunotherapeutics

, Volume 2, Issue 2, pp 84–88 | Cite as

Immune Function in Chronic Fatigue Syndrome and Depression

Implications for Understanding these Disorders and for Therapy
  • Andrew Lloyd
  • Ian Hickie
  • Andrew Wilson
  • Denis Wakefield
Leading Article


Considerable data now support the concept that patients with chronic fatigue syndrome and those with the melancholic subtype of major depression frequently have alterations in measures of immune function in vitro and in vivo. Although chronic fatigue syndrome and major depression have significant clinical similarity, the patterns of immunological and neuroendocrine alterations seen in the 2 disorders are dissimilar. The immunological changes provide tantalising clues to the pathophysiology of these disorders but, as yet, do not have clear implications for therapy.


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Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • Andrew Lloyd
    • 1
    • 2
    • 3
  • Ian Hickie
    • 4
    • 5
  • Andrew Wilson
    • 4
    • 5
  • Denis Wakefield
    • 2
    • 3
  1. 1.Department of Infectious Diseases, Division of MedicineThe Prince Henry HospitalLittle BayAustralia
  2. 2.Department of Immunopathology, Division of PathologyThe Prince Henry HospitalLittle BayAustralia
  3. 3.Inflammatory Diseases Unit, School of PathologyThe University of New South WalesSydneyAustralia
  4. 4.The Mood Disorders Unit, Division of PsychiatryThe Prince Henry HospitalLittle BayAustralia
  5. 5.School of PsychiatryThe University of New South WalesSydneyAustralia

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