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Effect of Antiulcer Drugs on Helicobacter pylori

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Summary

Helicobacter pylori is an important pathogen. It causes type B gastritis and is a probable pathogenic factor in duodenal ulcer disease. In vitro, H. pylori is susceptible to a large number of antimicrobial agents as well as to a few antiulcer agents, including bismuth salts [colloidal tripotassium dicitrato bismuthate (TDB), bismuth salicylate and bismuth subnitrate], metronidazole, furazolidone and sofalcone. In vivo efficacy of monotherapy in eradicating H. pylori long term is poor, with the best agent being colloidal TDB. In uncontrolled studies, polytherapy incorporating TDB is most effective, with eradication rates of over 90%.

The identification of a safe, effective regimen to eradicate H. pylori requires a detailed understanding of mucosal and systemic actions of the agents together with well conducted, controlled clinical trials.

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Correspondence to Dr John R. Lambert.

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Lambert, J.R. Effect of Antiulcer Drugs on Helicobacter pylori . Drug Invest 2, 52–55 (1990). https://doi.org/10.1007/BF03259182

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Keywords

  • Bismuth
  • Eradication Rate
  • Tinidazole
  • Nitrofuran
  • Carbenoxolone