Patients with mild to moderate hypertension while on therapy (33%) or those with moderate to severe hypertension while receiving no treatment (67%) were entered into an 8-week programme. Nifedipine 20mg prolonged action tablets were administered as 1 tablet twice daily for a minimum of 4 weeks, after which the dose was doubled if blood pressure measurements in the general practitioner's office warranted it.
The blood pressure fell from 169/102mm Hg initially to 144/85mm Hg after 8 weeks, when 88% of patients were receiving 1 tablet twice daily. Approximately 90% of patients, whether on combination therapy or taking nifedipine alone, reached a goal of 90mm Hg or less in 4 weeks. The heart rate did not change significantly from its initial value of 77 beats/min at any of the 2-weekly visits during the programme.
The 4 most common adverse experiences peaked at week 2 and, with the exception of peripheral oedema, declined thereafter.
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Consultants to the group were: Colin C. Barnes, Hamilton; Peter Bolli, S1. John’s; Ellen D. Burgess, Calgary; George H. Changfoot, New Westminster; John Cobby, Etobicoke; Satya P. Handa, Saint John; Marc Houde, Montreal; Louis E. Laplante, Montreal; Evan J. Monkman, Toronto; S. Brian Penner, Winnipeg; Eli Z. Rabin, Ottawa; Laurie R. Silverberg, Toronto; Clair C. Williams, Toronto; George G. Wu, Mississauga.
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Effectiveness of Nifedipine 20mg Prolonged Action Tablet (Adalat PA 20) in the Management of Hypertension in General Practice. Drug Invest 1, 24–28 (1989). https://doi.org/10.1007/BF03259163