Drug Investigation

, Volume 8, Issue 4, pp 225–233

Evaluation of Fluticasone Propionate Aqueous Nasal Spray Taken Alone and in Combination with Cetirizine in the Prophylactic Treatment of Seasonal Allergic Rhinitis

  • C. Benincasa
  • R. S. Lloyd
Original Research Article


This was a multicentre, double-blind study in 454 patients to compare the effectiveness and tolerability of fluticasone propionate nasal spray (FPANS) 200μg used once daily for 8 weeks on its own or in combination with oral cetirizine 10mg once daily in the treatment of seasonal allergic rhinitis. The results showed no significant difference between treatments in any of the symptoms or in the proportion of symptom-free days. Watery eyes were recorded as being the most troublesome symptom in the previous hayfever season, whilst during the study patients were, on average, free of eye symptoms for 56% of the time. Additionally, no difference was detected between the two groups with regard to the use of rescue medication. More than 75% of patients concluded at the end of the study that their symptoms had been adequately controlled and, similarly, investigators rated both treatments as being successful for the majority of patients. Overall, this study suggests that there is no significant difference in efficacy between FPANS 200μg, taken once daily in the morning, and FPANS 200μg once daily in combination with oral cetirizine 10mg, in the prophylactic treatment of seasonal allergic rhinitis.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Davies R. Seasonal rhinitis in rhinitis mechanisms and management. I Mackay, editor. Royal Society of Medicine 1989: 97–116Google Scholar
  2. 2.
    Sibbald B. Epidemiology of seasonal and perennial rhinitis: clinical presentation and medical library. Thorax 1991; 46: 895–901PubMedCrossRefGoogle Scholar
  3. 3.
    Allergy: conventional and alternative concepts. A report of the Royal College of Physicians Committee on Clinical Immunology and Allergy. Clin Exp Allergy 1992; 22: Suppl. 3Google Scholar
  4. 4.
    Horak F. Seasonal allergic rhinitis. Newer treatment approaches. Drugs 1993; 45(4): 518–27PubMedCrossRefGoogle Scholar
  5. 5.
    Bryson HM, Faulds D. Intranasal fluticasone propionate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in allergic rhinitis. Drugs 1992; 43(5): 760–75PubMedCrossRefGoogle Scholar
  6. 6.
    Laforce C, Dockhom R, Findlay S, et al. Fluticasone propionate treatment for seasonal allergic rhinitis is safe and effective in adults and adolescents. Abstract 60. J Allergy Clin Immunol 1991; 87(1: Pt 2): 153CrossRefGoogle Scholar
  7. 7.
    Ratner PH, Paull BR, Findlay SR, et al. Fluticasone propionate once daily is as effective as beclomethasone dipropionate twice daily in relieving symptoms of seasonal allergic rhinitis. Clin Exp Allergy 1990; 20Suppl. 1: 98Google Scholar
  8. 8.
    Johannessen TA. A comparison of fluticasone propionate, flunisolide and placebo in patients with seasonal allergic rhinitis to birch pollen - a multi-centre trial. Clin Exp Allergy 1990; 20Suppl. 1: 102Google Scholar
  9. 9.
    Cramer JA, Mattson RH, Prevey ML, et al. How often is medication taken as prescribed? A novel assessment technique. JAMA 1989; 261: 3273–7PubMedCrossRefGoogle Scholar
  10. 10.
    Harding SM. The human pharmacology of fluticasone propionate. Respiratory Medicine 1990; 84Suppl. A: 25–9PubMedCrossRefGoogle Scholar
  11. 11.
    Harding SM. Human pharmacology of fluticasone. Abstract no. AS 04. 04. Allergologie 1989; 12: 77Google Scholar
  12. 12.
    Davies BH, Mullins J, Couch HA. A comparison of cetirizine (Zirtek) and terfenadine (Triludan). Clin Trials J 1989; 26: 100–7Google Scholar
  13. 13.
    Beswick KBJ, Kenyan GS, Cherry JR. A comparative study of beclomethasone aqueous nasal spray with terfenadine tablets in seasonal allergic rhinitis. Curr Med Res Opin 1985; 9: 560–7PubMedCrossRefGoogle Scholar
  14. 14.
    Drouin MA. Is there a benefit to add loratidine to topical nasal steroids in patients with moderately severe seasonal allergic rhinoconjunctivitis? Allergy 1992: Suppl. 12(47): 172Google Scholar
  15. 15.
    Dolovich J, Anderson M, Chodirker W, et al. Fluticasone propionate: a large multi-centre trial. Respir Med 1990; 84Suppl. A: 31–2PubMedCrossRefGoogle Scholar
  16. 16.
    Darnell R. Multi-centre study of fluticasone propionate aqueous nasal spray and terfenadine tablets in seasonal rhinitis. Clin Exp Allergy 1990; 20Suppl. 1: 101Google Scholar

Copyright information

© Adis International Limited 1994

Authors and Affiliations

  • C. Benincasa
    • 1
  • R. S. Lloyd
    • 2
  1. 1.Allen and Hanburys LtdUxbridge, MiddlesexEngland, UK
  2. 2.Weeping Cross SurgeryStaffordEngland, UK

Personalised recommendations