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Haemodynamic Effects of Nebivolol in Patients with Coronary Artery Disease

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Summary

Nebivolol is a novel β1-adrenoceptor blocking drug with an unusual haemodynamic profile unlike that of classical β-blockers. In dogs and in healthy volunteers, it decreases blood pressure and heart rate but improves left ventricular function. We studied 10 male patients with coronary artery disease and heart failure (mean ejection fraction 46%). A Swan-Ganz catheter was placed into the pulmonary artery and the mean blood pressure, heart rate, pulmonary artery pressure, pulmonary wedge pressure, right atrial pressure, cardiac output and stroke volume were measured at rest and on exertion before and after 7 days’ treatment with oral nebivolol 5 mg/day. Whereas the blood pressure and the heart rate decreased significantly, the pulmonary artery and wedge pressures and right atrial pressure and cardiac output did not change during treatment. The stroke volume increased significantly. The maintained cardiac output cannot be explained by any changes in pre- or afterload; instead, a positive inotropic mechanism may be the explanation.

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Correspondence to Dr Stephan Brune.

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Brune, S., Tebbe, U., Schmidt, T. et al. Haemodynamic Effects of Nebivolol in Patients with Coronary Artery Disease. Drug Invest 3, 64–68 (1991). https://doi.org/10.1007/BF03258266

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Keywords

  • Cardiac Output
  • Stroke Volume
  • Pulmonary Artery Pressure
  • Atrial Pressure
  • Nebivolol