Molecular Diagnosis & Therapy

, Volume 15, Issue 3, pp 159–166 | Cite as

Role of DNA Repair Gene Polymorphisms in the Efficiency of Platinum-Based Adjuvant Chemotherapy for Non-Small Cell Lung Cancer

  • Juliette Mathiaux
  • Valérie Le Morvan
  • Marina Pulido
  • Jacques Jougon
  • Hugues Bégueret
  • Jacques Robert
Original Research Article

Abstract

Background: Cisplatin-based adjuvant treatment of non-small cell lung cancer (NSCLC) has become standard, thanks to the studies that have shown a significant survival advantage. The identification of patients who could benefit from this adjuvant treatment would allow ineffective and toxic administrations to be avoided. Immunohistochemical expression of the excision repair cross-complementation group (ERCC)-1 protein has been associated with response to platinum-based chemotherapy in patients with NSCLC, and some polymorphisms of the genes involved in DNA repair have been shown to be associated with survival in advanced NSCLC.

Objective: The aim of our study was to evaluate the progression-free survival and tolerability of adjuvant treatment with platinum-based chemotherapy in patients with NSCLC, according to common DNA repair gene polymorphisms and ERCC1 expression.

Methods: We investigated the association of three DNA repair gene polymorphisms — Asn118Asn in ERCC1 (rs11615), Lys751Gln in ERCC2 (rs13181), and Asp1104His in ERCC5 (rs17655) — with the progression-free survival of 85 patients treated with platinum-based chemotherapy after surgery for NSCLC.

Results: We did not find significant associations between any of these polymorphisms and progression-free survival, nor did we observe any difference in progression-free survival according to ERCC1 expression.

Conclusion: The previously reported impact of DNA repair gene polymorphisms on platinum-based chemotherapy treatment of advanced NSCLC was not observed in our study in the adjuvant setting.

Notes

Acknowledgments

We are grateful to the clinicians and pathologists involved in the study — Drs J. Dubrez, C. Klein, and A. Daubech — and to the clinical research assistants. JM received a fellowship from the Institut National du Cancer (Paris, France). This work was funded through INSERM U916 grants.

None of the authors has any conflict of interest to declare.

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Copyright information

© Adis Data Information BV 2011

Authors and Affiliations

  • Juliette Mathiaux
    • 1
    • 2
  • Valérie Le Morvan
    • 1
  • Marina Pulido
    • 3
  • Jacques Jougon
    • 2
  • Hugues Bégueret
    • 2
  • Jacques Robert
    • 1
  1. 1.Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 916Université de Bordeaux, Institut BergoniéBordeauxFrance
  2. 2.Hôpital du Haut-LévêqueCentre Hospitalier Universitaire de BordeauxBordeauxFrance
  3. 3.Institut BergoniéINSERM Centre d’Investigation Clinique (CIC)-EC7 et Unité de Recherche et d’Epidémiologie CliniquesBordeauxFrance

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