Molecular Diagnosis & Therapy

, Volume 12, Issue 5, pp 299–306 | Cite as

Diagnosis of Malaria

Challenges for Clinicians in Endemic and Non-Endemic Regions
  • Rachel N. BronzanEmail author
  • Meredith L. McMorrow
  • S. Patrick Kachur
Infectious Diseases


Malaria is a leading cause of morbidity and mortality worldwide. Prompt diagnosis and treatment are critical factors in reducing morbidity and mortality, as delayed treatment of malaria increases the risk of death. Microscopy has long been the standard of malaria diagnosis, but newer diagnostic tests now offer advantages in certain settings. Malaria diagnosis is complicated by the fact that acquired immunity to malaria can result in asymptomatic infections. In a symptomatic (febrile) patient, no existing malaria diagnostic test can distinguish malarial illness from parasitemia with concomitant fever of another cause. In this review we discuss the available malaria diagnostic tests, appropriate applications for each, and the challenges of malaria diagnosis in both endemic and non-endemic settings.


Malaria Entomologic Inoculation Rate Malaria Diagnosis Antimalarial Agent Plasmodium Knowlesi 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Adis Data Information BV 2008

Authors and Affiliations

  • Rachel N. Bronzan
    • 1
    Email author
  • Meredith L. McMorrow
    • 1
  • S. Patrick Kachur
    • 1
  1. 1.United States Public Health Service, Malaria Branch, Division of Parasitic DiseasesNational Center for Zoonotic Vector-Borne and Enteric Diseases, Centers for Disease Control and PreventionAtlantaUSA

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