Antioxidative effect of ginger supercritical extracts in L6 muscle cells was assessed. Ginger supercritical extract potently suppressed hydrogen peroxide-induced L6 muscle cell death and ATP reduction as compared to ginger ethanol extract. Results suggest the intake of ginger supercritical extracts may effectively protect muscle cells against damage induced by radically increased reactive oxygen species due to strenuous exercise.
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Badreldin HA, Gerald B, Musbah OT, and Abderrahim N (2008) Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research. Food Chem Toxicol 46, 409–420.
Bai J, Rodriguez AM, Melendez JA, and Cederbaum AI (1999) Overexpression of catalase in cytosolic or mitochondrial compartment protects HepG2 cells against oxidative injury. J Biol Chem 274, 262217–26224.
Bassuk SS and Manson JE (2005) Epidermiological evidence for the role of physical activity in reducing risk of type 2 diavetes and cardiovascular disease. J Appl Physiol 99, 1193–1204.
Black C, Herring M, Hurley D, and O’Connor P (2010) Ginger (Zinger officinale) reduces muscle pain caused by eccentric exercise. J Pain 11, 894–903.
Cheon JK, Ju CS, and Lee SH (1998) Extraction of ginger oil from Korean-grown ginger-root using supercritical carbon dioxide. J Korean Print Soc 16, 69–79.
Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, and Korlakunta JN (2010) Comparative antioxidant and anti-inflammatory effects of -gingerol, -gingerol, -gingerol and -shogaol. J Ethnopharm 127, 515–520.
Hyun KY (2009) An Association of changed levels of inflammatory markers with hematological factors during one-time aerobic exercise in twenty-aged young men. J Life Sci 19, 1658–1665.
Ippoushi K, Azuma K, Ito H, Horie H, and Higashio H (2003) -Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci 14, 3427–3437.
Ji LL (1996) Excercise, oxidative stress, and antioxidants. Am J Sports Med 42, 20–24.
Kim SY, Gao JG, Lee WC, Ryu KS, Lee KR, and Kim YC (1999) Antioxidative flavonoids from the leaves of morus alba. Arch Pharm Res 22, 81–85.
Schwertner HA and Rios DC (2007) High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10- gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages. J Chromatogr B 856, 41–47.
Tada-Oikawa S, Oikawa S, Kawanishi M, Yamada M, and Kawanishi S (1999) Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential during DNA alkylation-induced apoptosis. FEBS Lett 442, 65–69.
van den Berg R, Haenen GR, van den Berg H, and Bast A (1999) Applicability of an improved Trolox equivalent antioxidant capacity assay for evaluation of antioxidant capacity measurements of mixtures. Food Chem 66, 511–517.
Wang M, Jin Y, and Ho CT (1999) Evaluation of resveratrol derivatives as potential antioxidants and identification of a reaction product of resveratrol and 2,2-diphenyl-1- picryhydrazyl radical. J Agric Food Chem 47, 3974–3977.
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Lee, Y., Kim, K., Lee, M. et al. Protective effects of ginger supercritical extract against oxidative damage in L6 muscle cells. J Korean Soc Appl Biol Chem 54, 790–794 (2011). https://doi.org/10.1007/BF03253161
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