Advertisement

Journal of the Iranian Chemical Society

, Volume 3, Issue 3, pp 233–241 | Cite as

Neat reaction technology for the synthesis of 4-oxo-thiazolidines derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized 4-thiazolidinones

  • K. G. Desai
  • J. P. Raval
  • K. R. Desai
Article

Abstract

The synthesis of 4-thiazolidinones 4a-j in a good yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N’-benzylideneacetohydrazide 3a-j with SHCH2COOH in DMF in the presence of a catalytic amount of anhydrous ZnCl2 under microwave irradiation is described and compared with conventional synthesis methods. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Some of the new compounds were tested against bacteria (Gram− ve and Gramt+ ve) and fungi.

Keyword

4-Thiazolidinones Heterocyclization Microwave effect Antimicrobial activity 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Refeerences

  1. [1]
    K.R. Desai, K.H. Chikhalia, J.Indian Chem. Soc. 71 (1994) 155.Google Scholar
  2. [2]
    N. Guru, S.D. Srivastava, J.Scient. Ind. Res. 60 (2001) 601.Google Scholar
  3. [3]
    M.S. Chande, K.S. Jathar, Indian J. Chem. 34B (1995) 654.Google Scholar
  4. [4]
    S.N. Sawhney, P.K. Sharma, A. Gupta, Indian J. Chem. 32B (1993) 1190.Google Scholar
  5. [5]
    S.K. Srivastava, S.D. Srivastava, Indian J. Chem. 36B (1997) 826.Google Scholar
  6. [6]
    R.S. Lodhi, S.D. Srivastava, Indian J. Chem. 36B (1997) 947.Google Scholar
  7. [7]
    L. Jaish, S.K. Srivastava, J.Scient. Ind. Res. 60 (2001) 33.Google Scholar
  8. [8]
    Nizamuddin, A. Singh, Indian J. Chem. 43B (2004) 901.Google Scholar
  9. [9]
    S. Varma, Green Chem. 1 (1999) 43.Google Scholar
  10. [10]
    R. Borah, D.J. Kalita, J.C. Sarma, Indian J. Chem. 41B (2002) 1032.Google Scholar
  11. [11]
    M. Kidwai, B. Dave, R. Venkataramanan, Indian J. Chem. 41B (2002) 2414.Google Scholar
  12. [12]
    J.H. Clark, Green Chem. 1 (1999) 1.Google Scholar
  13. [13]
    R. Trotzki, M. Nuchter, B. Ondruschka, Green Chem. 5 (2003) 285.Google Scholar
  14. [14]
    K.G. Desai, K.R. Desai, Indian J. Chem. (Sec. B), In press.Google Scholar
  15. [15]
    M. Nuchter, B. Ondruschka, W. Bonrath, A. Gum. Green Chem. 6 (2004) 128.Google Scholar
  16. [16]
    V.M. Patel, K.R. Desai, ARKIVOC (USA), (www.arkat-usa.org). 1 (2004) 123.Google Scholar
  17. [17]
    K.G. Desai, K.R. Desai, Molbank (www.mdpi.org/molbank) (Switzerland), 2006, M475 (MOL File: m477. mol).Google Scholar
  18. [18]
    K.G. Desai, K.R. Desai, D. Padmanabhan, Molbank (www.mdpi.org/molbank) (Switzerland), 2006, M475 (MOL File: m478. mol).Google Scholar
  19. [19]
    A. Loupy, L. Perreux, M. Moneuse, Pure. Appl. Chem. 11 (2001) 161.Google Scholar
  20. [20]
    K.G. Desai, K.R. Desai, J.Heterocyclic Chem. 43 (2006) 1083..Google Scholar
  21. [21]
    K.G. Desai, K.R. Desai, Indian J. Chem. (Sec B). 44B (2005) 2093.Google Scholar
  22. [22]
    K.G. Desai, K.R. Desai, Indian J. Chem. (Sec B). 44B (2005) 2097.Google Scholar
  23. [23]
    S.K. Srivastava, S.D. Srivastava, Indian J. Chem. 43B (2004) 399.Google Scholar
  24. [24]
    K.G. Desai, K.R. Desai, J. Saudi Chem. Soc. 9 (2005) 631Google Scholar

Copyright information

© Iranian Chemical Society 2006

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of Science, Synthetic Organic Chemistry Research LaboratoryVeer Narmad South Gujarat UniversitySuratIndia
  2. 2.Industrial Chemistry Division, Department of ChemistryV.N.S.G. UniversitySuratIndia
  3. 3.Chemistry Department, Organic Chemistry Division, Faculty of ScienceV. N.S.G. UniversitySuratIndia

Personalised recommendations