Journal of the Iranian Chemical Society

, Volume 3, Issue 3, pp 233–241 | Cite as

Neat reaction technology for the synthesis of 4-oxo-thiazolidines derived from 2-SH-benzothiazole and antimicrobial screening of some synthesized 4-thiazolidinones

  • K. G. Desai
  • J. P. Raval
  • K. R. Desai


The synthesis of 4-thiazolidinones 4a-j in a good yields from the heterocyclization reaction of 2-(benzothiazol-2-ylthio)-N’-benzylideneacetohydrazide 3a-j with SHCH2COOH in DMF in the presence of a catalytic amount of anhydrous ZnCl2 under microwave irradiation is described and compared with conventional synthesis methods. All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral data. Some of the new compounds were tested against bacteria (Gram− ve and Gramt+ ve) and fungi.


4-Thiazolidinones Heterocyclization Microwave effect Antimicrobial activity 


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Copyright information

© Iranian Chemical Society 2006

Authors and Affiliations

  1. 1.Department of Chemistry, Faculty of Science, Synthetic Organic Chemistry Research LaboratoryVeer Narmad South Gujarat UniversitySuratIndia
  2. 2.Industrial Chemistry Division, Department of ChemistryV.N.S.G. UniversitySuratIndia
  3. 3.Chemistry Department, Organic Chemistry Division, Faculty of ScienceV. N.S.G. UniversitySuratIndia

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