Journal of the Iranian Chemical Society

, Volume 8, Issue 4, pp 1139–1145 | Cite as

The regioselective Synthesis of bromochlorins related to chlorophyll-a from methyl pheophorbide-a

Article
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Abstract

An efficient methodology has been developed for the regioselective synthesis of brominated chlorins related to chlorophyll-a from methyl pheophorbide-a. Several regioselective bromination reactions were accomplished by some particular reaction conditions and a series of conversion of functional group from methyl pheophorbide-a to synthesize mono-, bis- and tri-brominated chlorines. The possible mechanisms for the debromination were tentatively proposed and the structures of all new chlorins were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectra.

Keywords

Chlorophyll-a Chlorin Bromination Regioselective synthesis Photodynamic therapy (PDT) 
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Copyright information

© Iranian Chemical Society 2011

Authors and Affiliations

  1. 1.Science and Engineering College of Chemistry and BiologyYantai UniversityYantaiP. R. China

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