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Uncatalyzed and solvent-free one-pot three component synthesis of α-amino phosphonates

Abstract

An innovative route to preaper a number of variously substituted α-aminophosphonate is presented. The protocol avoids the use of any catalyst, organic solvents, and dry reaction conditions. The synthesis of α-aminophosphonates in the present study represents a three-component reaction in which no intermediate formation of either an imine or α-hydroxy phosphonate was observed.

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Author information

Correspondence to M. Hosseini-Sarvari.

Additional information

This paper is dedicated to Prof. Habib Firouzabadion on the occasion of his 65th birthday and also his retirement

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Hosseini-Sarvari, M. Uncatalyzed and solvent-free one-pot three component synthesis of α-amino phosphonates. JICS 5, S118–S124 (2008). https://doi.org/10.1007/BF03246500

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Keywords

  • Catalyst free
  • Solvent free
  • α-Aminophosphonates
  • Aldehydes
  • Amine