Different Lewis acids were screened to catalyze the reaction of 2-amino-thiophene-3-carboxylate, orthoformate and aryl amine to form 2-substituted thieno[2,3-d]pyrimidin-4(3H)-one. Zn(OAc)2 was demonstrated to efficiently catalyze the reaction. 20 substituted thieno[2,3-d]pyrimidines were synthesized by adding 0.5% mol Zn(OAc)2 as catalyst under microwave irradiation.
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CCDC 749793 contains the supplementary crystallographic data for the structures reported in this article. These data can be obtained free of charge from the Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif
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Jing, X., Li, Z., Wu, L. et al. Zn(OAc)2 catalyzed microwave irradiated synthesis of substituted thieno[2,3-d]pyrimidin-4(3H)-one. JICS 8, 107–114 (2011). https://doi.org/10.1007/BF03246207
- Microwave irradiation