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Highly chemoselective reductive amination by one pot reaction of aldehydes, amines and Dihydropyridine Catalyzed by TMSCl

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Abstract

More efficient, cost effective and metal free DHP/TMSCl system for one pot reductive amination of aldehydes was developed. The method allows the efficient one pot synthesis of structurally diverse amines with Hantzsch ester as the hydrogen source in the presence of trimethylsilyl chloride as a catalyst in high to quantitative yields under mild conditions.

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Correspondence to N. Azizi.

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Azizi, N., Khajeh Amiri, A.R., Ghafuri, H. et al. Highly chemoselective reductive amination by one pot reaction of aldehydes, amines and Dihydropyridine Catalyzed by TMSCl. JICS 7, 428–431 (2010). https://doi.org/10.1007/BF03246028

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Keywords

  • Aldehydes
  • Amines
  • Dihydropyridine
  • Reductive amination
  • TMSCl