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Synthesis and immunomodulatory activity of some novel amino acid germinates

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Abstract

Amino acid germanate compounds are synthesized by the chemical reaction of germanium dioxide with a selected amino acid in the presence of an alkali medium at a suitable elevated temperature. Amino acids included in the novel synthesis include histidine, methionine and glutathione. The study evaluated their effects on induction of interleukin-12 and interferon-γl in Swiss albino Webster rats. The new germanium compounds, especially bis-methionino germanate, are considered as good interferon inducer that significantly enhance the immunologic function.

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Correspondence to A. A. Hafiz.

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Badawi, A.M., Hafiz, A.A. Synthesis and immunomodulatory activity of some novel amino acid germinates. JICS 4, 107–113 (2007). https://doi.org/10.1007/BF03245808

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Keywords

  • Amino acid germanate-immunomodulatory
  • Interferon-γ
  • Interleukin-12