Macromolecular Research

, Volume 14, Issue 3, pp 324–330 | Cite as

Evaluation of new selective molecularly imprinted polymers for the extraction of resveratrol frompolygonum cuspidatum

  • Hui Cao
  • Jian Bo Xiao
  • Ming Xu


Four different molecularly imprinted polymers (MIPs)|were prepared using resveratrol as the template, methacrylic acid (MAA)|or acrylamide (AA)|as functional monomers, 2, 2-azobisisobutyronitrile (AIBN)|as the initiator, and thermo- or photo-induced polymerization. The ability of the different polymers to rebind selectively not only the template but also other phenols was evaluated. In parallel, the influence of the different templates and functional monomers used during polymer syntheses on the performance of the obtained MIPs was also studied through different rebinding experiments. The binding ability and selectivity of the polymer were studied by static balance method and Scatchard analysis. It was concluded that AA-based polymer by photo-induced polymerization presents the best properties to be used as a selective absorbent for the extraction of resveratrol.


molecularly imprinted polymers resveratrol isotherms binding sites 


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  1. (1).
    A. G. Mayes and K. Mosbach,Trends Anal. Chem.,16, 321 (1997).CrossRefGoogle Scholar
  2. (2).
    P. A. G. Cormack and A. Z. Elorza,J. Chromatogr. B,804, 173 (2004).CrossRefGoogle Scholar
  3. (3).
    W. Donga, M. Yan, M. L. Zhang, Z. Liu, and Y. M. Li,Anal. Chim. Acta,542, 186 (2005).CrossRefGoogle Scholar
  4. (4).
    J. O. Mahony, A. Molinelli, K. Nolan, M. R. Smyth, and B. Mizaikoff,Biosens. Bioelectron.,21, 1383 (2006).CrossRefGoogle Scholar
  5. (5).
    D. Kriz and K. Mosbach,Anal. Chim. Acta,300, 71 (1995).CrossRefGoogle Scholar
  6. (6).
    T. Y. Guo, Y. Q. Xia, J. Wang, M. D. Song, and B. H. Zhang,Biomaterials,26, 5737 (2005).CrossRefGoogle Scholar
  7. (7).
    C. Baggiani, L. Anfossi, P. Baravalle, C. Giovannoli, and C. Tozzi,Anal. Chim. Acta,531, 199 (2005).CrossRefGoogle Scholar
  8. (8).
    J. M. Elhiney and L. A. Lawton,Toxicol. Appl. Pharm.,203, 219 (2005).CrossRefGoogle Scholar
  9. (9).
    J. O. Mahony, K. Nolan, M. R. Smyth, and B. Mizaikoff,Anal. Chim. Acta,534, 31 (2005).CrossRefGoogle Scholar
  10. (10).
    R. Suedee, T. Srichana, C. Sangpagai, C. Tunthana, and P. Vanichapichat,Anal. Chim. Acta,504, 89 (2004).CrossRefGoogle Scholar
  11. (11).
    L. Feng, Y. J. Liu, X. D. Zhou, and J. M. Hu,J. Colloid Interf. Sci.,284, 378 (2005).CrossRefGoogle Scholar
  12. (12).
    M. Matsuguchi and T. Uno,Sensor. Actuat. B,113, 94 (2006).CrossRefGoogle Scholar
  13. (13).
    J. Bastide, J. P. Cambon, F. Breton, S. A. Piletsky, and R. Rouillon,Anal. Chim. Acta,542, 97 (2005).CrossRefGoogle Scholar
  14. (14).
    S. G. Hu, L. Li, and X. W. He,J. Chromatogr. A,1062, 31 (2005).CrossRefGoogle Scholar
  15. (15).
    D. Coutinho, A. O. Acevedo, and G. R. Dieckmann,Micropor. Mesopor. Mat.,54, 249 (2002).CrossRefGoogle Scholar
  16. (16).
    L. Zhou, J. C. Xie, and Y. F. Ge,Acta. Phys. Chim. Sin.,18, 808 (2002).Google Scholar
  17. (17).
    G. J. Soleas, E. P. Diamandis, and D. M. Goldberg,Clin. Biochem.,30, 91 (1997).CrossRefGoogle Scholar
  18. (18).
    L. Fremont,Life Sci.,66, 663 (2000).CrossRefGoogle Scholar
  19. (19).
    V. G. Soto,Drug News Perspect,16, 299 (2003).CrossRefGoogle Scholar
  20. (20).
    J. M. Wu, Z. R. Wang, T. C. Hsieh, J. L. Bruder, J. G. Zou, and Y. Z. Huang,Int. J. Mol. Med.,8, 3 (2001).Google Scholar
  21. (21).
    F. Bianchini and H. Vainio,Eur. J. Cancer Prev.,12, 417 (2003).CrossRefGoogle Scholar
  22. (22).
    M. J. Syu, J. H. Deng, and Y. M. Nian,Anal. Chem. Acta,504, 167 (2004).CrossRefGoogle Scholar

Copyright information

© The Polymer Society of Korea and Springer 2006

Authors and Affiliations

  1. 1.School of Chemistry and Chemical EngineeringNantong UniversityNantongPR China
  2. 2.College of Chemistry and Chemical EngineeringCentral South UniversityChangshaPR China
  3. 3.Research Institute for Molecular Pharmacology and TherapeuticsCentral South UniversityChangshaPR China
  4. 4.Department of Radiation OncologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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