Macromolecular Research

, Volume 17, Issue 12, pp 1010–1014 | Cite as

Core-shell poly(d,l-lactide-co-glycolide)/poly(ethyl 2-cyanoacrylate) microparticles with doxorubicin to reduce initial burst release

  • Sang-Hyuk Lee
  • Hyon-Ho Baek
  • Jung Hyun Kim
  • Sung-Wook Choi
Article
Received:
Revised:
Accepted:

Abstract

Monodispersed microparticles with a poly(d,l-lactide-co-glycolide) (PLGA) core and a poly(ethyl 2-cyanoacrylate) (PE2CA) shell were prepared by Shirasu porous glass (SPG) membrane emulsification to reduce the initial burst release of doxorubicin (DOX). Solution mixtures with different weight ratios of PLGA polymer and E2CA monomer were permeated under pressure through an SPG membrane with 1.9 ώm pore size into a continuous water phase with sodium lauryl sulfate as a surfactant. Core-shell structured microparticles were formed by the mechanism of anionic interfacial polymerization of E2CA and precipitation of both polymers. The average diameter of the resulting microparticles with various PLGA:E2CA ratios ranged from 1.42 to 2.73 ώm. The morphology and core-shell structure of the microparticles were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The DOX release profiles revealed that the microparticles with an equivalent PLGA:E2CA weight ratio of 1:1 exhibited the optimal condition to reduce the initial burst of DOX. The initial release rate of DOX was dependent on the PLGA:E2CA ratio, and was minimized at a 1:1 ratio.

Keywords

core-shell poly(d,l-lactide-co-glycolide) ethyl 2-cyanoacrylate membrane emulsification doxorubicin 
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Copyright information

© The Polymer Society of Korea and Springer 2009

Authors and Affiliations

  • Sang-Hyuk Lee
    • 1
  • Hyon-Ho Baek
    • 1
  • Jung Hyun Kim
    • 1
  • Sung-Wook Choi
    • 2
  1. 1.Nanosphere Process & Technology Laboratory, Department of Chemical and Biomolecular EngineeringYonsei UniversitySeoulKorea
  2. 2.Department of Biomedical EngineeringWashington University in St. LouisSt. Louis

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