Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Mid-term follow up results of Japanese heart transplant patients operated in UCLA Medical Center

  • 20 Accesses

Abstract

Japanese candidates have been accepted for heart transplantation by the UCLA Medical Center in the US since 1993 due to the lack of donors available from brain-dead patients.Objectives and Methods: We monitored to patients who underwent such heart transplantation and have been seen at the out-patient clinic at Tokyo Women’s Medical University following transplantation. Pre-operative diagnosis was dilated cardiomyopathy in all patients. One patient underwent Novacor implantation as a bridge to heart transplant. All patients underwent cardiac echocardiography and cardiac catheterization including intraluminal echography.Results: All patients survived with an actuarial survival curve of 100% at 1year, 100% at 3 years and 87% at 5 years in 4.15 years of average follow-up. Two patients died due to liver dysfunction and cerebral emboli. The postoperative functional status of patients was New York Heart Association classification I in 8 (100%). Immunosuppressive therapies included triple drug therapy using either cyclosporin or tacrolimus. The incidence of acute rejection (/pt) exceeding grade 3 was 4% within three months, 3.5% in 3–6 months, and no significant rejection episode more than 6 months after transplantation. Posttransplantation coronary artery disease was seen in 2 patients, but no progression was seen after diltiazem therapy.Conclusion: Our postoperative follow-up after cardiac transplantation appears to be satisfactory.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Hachida M, Koyanagi H, Matsuda H, Sono J, Akasaka T, Tanaka K, et al. Assessment of Japanese patients receiving heart transplants overseas. J Cardiol 1996; 27: 15–19.

  2. 2.

    Hosenpud JD, Novick RJ, Breen TJ, Daily OP: The Registry of the International Society for Heart and Lung Transplantation: 11th Official Report-1994. J Heart Lung Transplant 1994; 13: 561–70.

  3. 3.

    Hachida M, Nonoyama, M, Hanayama N, Hoshi H, Bonkohara Y, Koyanagi H. The rescue effect of FK506 in refractory rejection after cardiac transplantation. J Jpn Assn Thorac Surg 1994; 42: 1972–6.

  4. 4.

    Dunning JJ, Kendall SWH, Mullins PA, Chauhan A, Graham TR. Coronary artery bypass grafting 9 years after cardiac transplantation. Ann Thorac Surg. 1992; 54: 571–2.

  5. 5.

    Gao SZ, Alderman EL, Schroeder JS, Silverman JF, Hunt SA. Accelerated coronary vascular disease in heart transplant patient coronary arteriographic findings. J Am Coll Cardiol 1989; 12: 334–40.

Download references

Author information

Correspondence to Mitsuhiro Hachida.

Additional information

Read at the Fifty-second Annual Meeting of The Japanese Association for Thoracic Surgery, Panel Discussion, Sendai, October 5–7, 1999.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hachida, M., Nonoyama, M., Hanayama, N. et al. Mid-term follow up results of Japanese heart transplant patients operated in UCLA Medical Center. Jpn J Thorac Caridovasc Surg 48, 713–716 (2000). https://doi.org/10.1007/BF03218238

Download citation

Key words

  • heart transplantation
  • immunosuppressive therapy
  • acute rejection
  • dilated cardiomyopathy