Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Inhibition of cholesterol absorption by HMG-CoA reductase inhibitor

  • 25 Accesses

  • 16 Citations

Summary

In subjects with familial hypercholesterolemia cholesterol absorption efficiency was insignificantly reduced during a short-term more consistently during long-term pravastatin treatment. A cholesterol feeding had no effect on LDL cholesterol level but reduced absorption efficiency during a long-term lovastatin treatment.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Grundy SM (1988) HMG-CoA reductas inhibitors for treatment of hypercholesterolemia. N Engl J Med 319: 24–33

  2. 2.

    Grundy SM, Bilheimer DW (1984) Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance. Proc Natl Acad Sci USA 81: 2538–2542

  3. 3.

    Goldberg IJ, Holleran S, Ramakrishnan R, Palmer RH, Dell RB, Goodman DS (1988) Effect of long-term treatment with lovastatin on the parameters of whole-body cholesterol metabolism. Arteriosclerosis 8: 588 a

  4. 4.

    Kempen HJM, Glatz JFC, Gevers Leuven JA, Voort HA van der, Katan MB (1988) Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J Lipid Res 29: 1149–1151

  5. 5.

    Miettinen TA (1991) Cholesterol metabolism during hypolipidemic treatment with inhibitors of cholesterol synthesis. 5th European Symposium on Metabolism, Padova. Excerpta Medica Congress Series. Elsevier, Amsterdam (in press).

  6. 6.

    Pappu AS, Illingworth R, Bacon S (1989) Reduction in plasma low-density lipoprotein cholesterol and urinary mevalonic acid by lovastatin in patients with heterozygous familial hypercholesterolemia. Metabolism 38: 542–549

  7. 7.

    Ginsberg HN, Le N-A, Short MP, Ramakrishnan R, Desnick RJ (1987) Suppression of apolipoprotein B production during treatment of cholesteryl ester storage disease with lovastatin. J Clin Invest 80: 1692–1697

  8. 8.

    Miettinen TA, Kesäniemi YA (1989) Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels. Am J Clin Nutr 49: 629–635

  9. 9.

    Tilvis RS, Miettinen TA (1980) A lack of esterification of lanosterol and other methyl sterols in human serum in vitro. Scand J Clin Lab Invest 40: 671–674

  10. 10.

    Tavani DM, Nes WR, Bilheimer JT (1982) The sterol substrate specificity of acyl CoA:cholesterol acyltransferase from rat liver. J Lipid Res 23: 774–781

  11. 11.

    Nordby G, Norum K (1975) Substrate specificity of lecithin:cholesterol acyltransferase. Esterification of desmosterol, β-sitosterol and cholecalciferol in human plasma. Scand J Clin Lab Invest 35: 677–682

  12. 12.

    Tilvis R, Miettinen TA (1986) Serum plant sterols and their relation to cholesterol absorption. Am J Clin Nutr 43: 92–97

  13. 13.

    Miettinen TA, Tilvis RS, Kesäniemi YA (1989) Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men. Metabolism 38: 136–140

  14. 14.

    Miettinen TA, Tilvis RS, Kesäniemi YA (1990) Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in a random male population. Am J Epidemiol 131: 20–31

  15. 15.

    Miettinen TA (1988) Regulation of serum cholesterol by cholesterol absorption. In: Parnham MJ, Niemann R (eds) Cologne Atherosclerosis Conference no.4: Cholesterol-Homeostasis. Birkhäuser, Basel, pp 53–65

  16. 16.

    Miettinen TA, Tikkanen M, Helve E, Ojala JP (1990) Inhibition of dietary cholesterol absorption during lovastatin (Merinolin) treatment. Drug Invest 2 [Suppl 2]: 29–35

  17. 17.

    Miettinen TA (1988) Cholesterol metabolism during ketoconazole treatment. J Lipid Res 29: 43–51

  18. 18.

    Ishida F, Sato A, Iizuka Y, Sawasaki Y, Aizawa A, Kamei T (1988) Effects of MK-733, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, on absorption and excretion of [3H]cholesterol in rabbits. Biochim Biophys Acta 963: 35–41

  19. 19.

    Ishida F, Sato A, Iizuka Y, Kitani K, Sawasaki Y, Kamei T (1989) Effects of MK-733 (simvastatin), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on intestinal acylcoenzyme A:cholesterol acyltransferase activity in rabbits. Biochim Biophys Acta 1004: 117–123

  20. 20.

    Schroepfer GJ Jr, Christophe A, Needleman DH, Kisic A, Sherrill BC (1987) Inhibitors of sterol synthesis. Dietary administration of 5α-cholest-8(14)-en-3β-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats. Biochem Biophys Res Commun 146: 1003–1008

  21. 21.

    Needleman DH, Strong K, Stemke KA, Brabson JS, Kisic A, Schroepfer GJ Jr (1987) Inhibitors of sterol synthesis. Effect of dietary 5α-cholest-8(14)-en-3β-ol-15-one on ACAT activity of jejunal microsomes of the rat. Biochem Biophys Res Commun 148: 920–925

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Miettinen, T.A. Inhibition of cholesterol absorption by HMG-CoA reductase inhibitor. Eur J Clin Pharmacol 40, S19–S21 (1991). https://doi.org/10.1007/BF03216283

Download citation

Key words

  • Statins
  • lathosterol
  • methyl sterols
  • cholesterol absorption
  • LDL cholesterol
  • dietary cholesterol