Gold Bulletin

, Volume 43, Issue 1, pp 29–41 | Cite as

Gold nanoparticle-based biosensors

  • Yuanyuang Li
  • Hermann J. Schluesener
  • Shunqing Xu
Open Access
Scientific Papers


The unique properties of gold nanoparticles have stimulated the increasing interest in the application of GNPs in interfacing biological recognition events with signal transduction and in designing biosensing devices exhibiting novel functions. The optical properties of GNPs provide wide range opportunities for construction optical biosensors. The excellent biocompatibility, conductivity, catalytic properties and high surface-to-volume ratio and high density of GNPs facilitate extensive application of GNPs in construction of electrochemical and piezoelectric biosensors with enhanced analytical performance with respect to other biosensor designs. In this article, the recent advances in construction of GNP-based optical, electrochemical and piezoelectric biosensors are reviewed, and some illustrative examples given, with a focus on the roles GNPs play in the biosensing process and the mechanism of GNPs for improving the analytical performances. Finally, the review concludes with an outline of present and future research for the real-world applications.


gold nanoparticle biosensor optical sensor electrochemical sensor piezoelectric sensor 


  1. 1.
    L.C. Clark, Jr. and C. Lyons,Ann NY Acad Sci, 1962,102, 29CrossRefGoogle Scholar
  2. 2.
    T. Vo-Dinh and B. Cullum,Fresenius J Anal Chem, 2000,366, 540CrossRefGoogle Scholar
  3. 3.
    K.K. Jain,Med Device Technol, 2003,14, 10Google Scholar
  4. 4.
    Y. Xiao, F. Patolsky, E. Katz, J.F. Hainfeld and I. Willner,Science, 2003,299, 1877CrossRefGoogle Scholar
  5. 5.
    M. Schierhorn, S.J. Lee, S.W. Boettcher, G.D. Stucky and M. Moskovits,Advanced Materials, 2006,18, 2829CrossRefGoogle Scholar
  6. 6.
    H. Cai, Y. Xu, N. Zhu, P. He and Y. Fang,Analyst, 2002,127, 803CrossRefGoogle Scholar
  7. 7.
    X.L. Luo, J.J. Xu, W. Zhao and H.Y. Chen,Biosens Bioelectron, 2004,19, 1295CrossRefGoogle Scholar
  8. 8.
    J. Wang, G. Liu, R. Polsky and A. Merkoçi,Electrochemistry Communications, 2002,2, 722CrossRefGoogle Scholar
  9. 9.
    X. Luo, A. Morrin, A.J. Killard and M.R. Smyth,Electroanalysis, 2006,18, 319CrossRefGoogle Scholar
  10. 10.
    J. Wang, R. Polsky and D. Xu,Langmuir, 2001,17, 5739CrossRefGoogle Scholar
  11. 11.
    J. Wang, D. Xu and R. Polsky,J Am Chem Soc, 2002,124, 4208CrossRefGoogle Scholar
  12. 12.
    J. Liu and Y. Lu,J Am Chem Soc, 2003,125, 6642CrossRefGoogle Scholar
  13. 13.
    Y. Qi, B. Li and Z. Zhang,Biosensors and Bioelectronics, 2009,24, 3581CrossRefGoogle Scholar
  14. 14.
    C.J. Murphy, A.M. Gole, S.E. Hunyadi, J.W. Stone, P.N. Sisco, A. Alkilany, B.E. Kinard and P. Hankins, Chem Commun (Camb), 2008, 544Google Scholar
  15. 15.
    M.C. Daniel and D. Astruc,Chem Rev, 2004,104, 293CrossRefGoogle Scholar
  16. 16.
    M. Hu, J. Chen, Z.Y. Li, L. Au, G.V. Hartland, X. Li, M. Marquez and Y. Xia,Chem Soc Rev, 2006,35, 1084CrossRefGoogle Scholar
  17. 17.
    S. Link and M.A. El-Sayed,J. Phys. Chem. B, 1996,103, 8410CrossRefGoogle Scholar
  18. 18.
    P. Mulvaney,Langmuir, 1996,12, 788CrossRefGoogle Scholar
  19. 19.
    P. Englebienne,The Analyst, 1998,123, 1599CrossRefGoogle Scholar
  20. 20.
    I.M. Klotz,Q Rev Biophys, 1985,18, 227CrossRefGoogle Scholar
  21. 21.
    D. Eck and C.A. Helm,Langmuir, 2001,17, 957CrossRefGoogle Scholar
  22. 22.
    N. Nath and A. Chilkoti,Anal Chem, 2002,74, 504CrossRefGoogle Scholar
  23. 23.
    N. Nath and A. Chilkoti,Anal Chem, 2004,76, 5370CrossRefGoogle Scholar
  24. 24.
    Z.M. Qi, I. Honma and H. Zhou,Opt Lett, 2006,31, 1854CrossRefGoogle Scholar
  25. 25.
    H.Y. Lin, C.T. Chen and Y.C. Chen,Anal Chem, 2006,78, 6873CrossRefGoogle Scholar
  26. 26.
    T. Okamoto, I. Yamaguchi and T. Kobayashi,Opt Lett, 2000,25, 372CrossRefGoogle Scholar
  27. 27.
    P. Englebienne, Van Hoonacker and J. Valsamis,Clin Chem, 2000,46, 2000Google Scholar
  28. 28.
    L.K. Chau, Y.F. Lin, S.F. Cheng and T.J. Lin,Sensors and Actuators B: Chemical, 2006,113, 100CrossRefGoogle Scholar
  29. 29.
    M.P. Jonsson, P. Jonsson, A.B. Dahlin and F. Hook,Nano Lett, 2007,7, 3462CrossRefGoogle Scholar
  30. 30.
    S.M. Marinakos, S. Chen and A. Chilkoti,Anal Chem, 2007,79, 5278CrossRefGoogle Scholar
  31. 31.
    T. Endoa, S. Yamamurab, K. Kermanc and E. Tamiyab,Analytica Chimica Acta, 2008,614, 182CrossRefGoogle Scholar
  32. 32.
    S. Takae, Y. Akiyama, Y. Yamasaki, Y. Nagasaki and K. Kataoka,Bioconjug Chem, 2007,18, 1241CrossRefGoogle Scholar
  33. 33.
    L.A. Lyon, M.D. Musick and M.J. Natan,Anal Chem, 1998,70, 5177CrossRefGoogle Scholar
  34. 34.
    L. He, M.D. Musick, S.R. Nicewarner, F.G. Salinas, S.J. Benkovic, M.J. Natan and C.D. Keating,Journal of the American Chemical Society, 2000,122, 9071CrossRefGoogle Scholar
  35. 35.
    E. Hutter, S. Cha, J.F. Liu, J. Park, J. Yi, J.H. Fendler and D. Roy,The Journal of Physical Chemistry B, 2001,105, 8CrossRefGoogle Scholar
  36. 36.
    X. Yang, Q. Wang, K. Wang, W. Tan and H. Li,Biosens Bioelectron, 2007,22, 1106CrossRefGoogle Scholar
  37. 37.
    L.A. Lyon, M.D Musick, P.C. Smith, B.D. Reiss, D.J. Peña and M.J. Natan,Sensors and Actuators B: Chemical, 1999,54, 118CrossRefGoogle Scholar
  38. 38.
    E. Fua, S. A, R. b and P. Yager,Analytica Chimica Acta, 2007,599, 118CrossRefGoogle Scholar
  39. 39.
    C. Cao and S.J. Sim,Biosens Bioelectron, 2007,22, 1874CrossRefGoogle Scholar
  40. 40.
    E. Fu, S.A. Ramsey and P. Yager,Analytica Chimica Acta, 2007,599, 118CrossRefGoogle Scholar
  41. 41.
    L.A. Lyon, M.D. Musick, P.C. Smith, B.D. Reiss, D.J. Peña and M.J. Natan,Sensors and Actuators B: Chemical, 1999,54, 118CrossRefGoogle Scholar
  42. 42.
    G. Xu, H. Li, X. Ma, X. Jia, J. Dong and W. Qian,Biosens Bioelectron, 2009,25, 362CrossRefGoogle Scholar
  43. 43.
    T.J. Lin, K.T. Huang and C.Y. Liu,Biosens Bioelectron, 2006,22, 513CrossRefGoogle Scholar
  44. 44.
    Y. Li, A.W. Wark, H.J. Lee and R.M. Corn,Anal Chem, 2006,78, 3158CrossRefGoogle Scholar
  45. 45.
    Y. Lei, H. Chen, H. Dai, Z. Zeng, Y. Lin, F. Zhou and D. Pang,Biosens Bioelectron, 2008,23, 1200CrossRefGoogle Scholar
  46. 46.
    Y. Luo, F. Yu and R.N. Zare,Lab Chip, 2008,8, 694CrossRefGoogle Scholar
  47. 47.
    J. Matsui, K. Akamatsu, N. Hara, D. Miyoshi, H. Nawafune, K. Tamaki and N. Sugimoto,Anal Chem, 2005,77, 4282CrossRefGoogle Scholar
  48. 48.
    Y. Sato, K. Sato, K. Hosokawa and M. Maeda,Anal Biochem, 2006,355, 125CrossRefGoogle Scholar
  49. 49.
    M. Zayats, A.B. Kharitonov, S.P. Pogorelova, O. Lioubashevski, E. Katz and I. Willner,J Am Chem Soc, 2003,125, 16006CrossRefGoogle Scholar
  50. 50.
    Y.T. Tseng, Y.J. Chuang, Y.C. Wu, C.S. Yang, M.C. Wang and F.G. Tseng,Nanotechnology, 2008,19, 345501CrossRefGoogle Scholar
  51. 51.
    M.K. Hossain, G.G. Huang, T. Kaneko and Y. Ozaki,Phys Chem Chem Phys, 2009,11, 7484CrossRefGoogle Scholar
  52. 52.
    Y.C. Cao, R. Jin and C.A. Mirkin,Science, 2002,297, 1536CrossRefGoogle Scholar
  53. 53.
    E. Katz, I. Willner and J. Wang,Electroanalysis, 2004,16, 19CrossRefGoogle Scholar
  54. 54.
    A. Amine, J.M. Kauffmann, G.G. Guilbault and S. Bacha,Analytical Letters, 1993,26, 1281Google Scholar
  55. 55.
    T. Ikeda, H. Hamada, K. Miki and M. Senda,Agricultural and Biological Chemistry 1985,49, 541Google Scholar
  56. 56.
    J. Losada and M.P.G. Armada,Electroanalysis, 1997,9, 1416CrossRefGoogle Scholar
  57. 57.
    K.R. Brown, A.P. Fox and M.J. Natan,Journal of the American Chemical Society, 1996,118, 1154CrossRefGoogle Scholar
  58. 58.
    J. Lin, W. Qu and S. Zhang,Anal Biochem, 2007,360, 288CrossRefGoogle Scholar
  59. 59.
    T. Tangkuaram, C. Ponchio, T. Kangkasomboon, P. Katikawong and W. Veerasai,Biosens Bioelectron, 2007,22, 2071CrossRefGoogle Scholar
  60. 60.
    V.V. Shumyantseva, S. Carrara, V. Bavastrello, D. Jason Riley, T.V. Bulko, K.G. Skryabin, A.I. Archakov and C. Nicolini,Biosens Bioelectron, 2005,21, 217CrossRefGoogle Scholar
  61. 61.
    Q. Xu, C. Mao, N.N. Liu, J.J. Zhu and J. Sheng,Biosens Bioelectron, 2006,22, 768CrossRefGoogle Scholar
  62. 62.
    J. Jia, B. Wang, A. Wu, G. Cheng, Z. Li and S. Dong,Anal Chem, 2002,74, 2217CrossRefGoogle Scholar
  63. 63.
    L. Zhang, X. Jiang, E. Wang and S. Dong,Biosens Bioelectron, 2005,21, 337CrossRefGoogle Scholar
  64. 64.
    V. Carralero, M.L. Mena, A. Gonzalez-Cortes, P. Yanez-Sedeno and J.M. Pingarron,Biosens Bioelectron, 2006,22, 730CrossRefGoogle Scholar
  65. 65.
    S. Liu, L. Peng, X. Yang, Y. Wu and L. He,Anal Biochem, 2008,375, 209CrossRefGoogle Scholar
  66. 66.
    L. Zhang, R. Yuan, Y. Chai and X. Li,Anal Chim Acta, 2007,596, 99CrossRefGoogle Scholar
  67. 67.
    S. Liu and H. Ju,Biosens Bioelectron, 2003,19, 177CrossRefGoogle Scholar
  68. 68.
    X.L. Luo, J.J. Xu, Y. Du and H.Y. Chen,Anal Biochem, 2004,334, 284CrossRefGoogle Scholar
  69. 69.
    M.H. Xue, Q. Xu, M. Zhou and J.J. Zhu,Electrochemistry Communications, 2006,8, 1468CrossRefGoogle Scholar
  70. 70.
    R. Shenhar, T.B. Norsten and V.M. Rotello,Advanced Materials, 2005,17, 6570669Google Scholar
  71. 71.
    F. Gao, R. Yuan, Y. Chai, S. Chen, S. Cao and M. Tang,J Biochem Biophys Methods, 2007,70, 407CrossRefGoogle Scholar
  72. 72.
    G. Yang, R. Yuan and Y.Q. Chai,Colloids Surf B Biointerfaces, 2008,61, 93CrossRefGoogle Scholar
  73. 73.
    W. Li, R. Yuan, Y. Chai, L. Zhou, S. Chen and N. Li,J Biochem Biophys Methods, 2008,70, 830CrossRefGoogle Scholar
  74. 74.
    J. Njagi and S. Andreescu,Biosens Bioelectron, 2007,23, 168CrossRefGoogle Scholar
  75. 75.
    J. Wu, F. Yan, X. Zhang, Y. Yan, J. Tang and H. Ju,Clin Chem, 2008,54, 1481CrossRefGoogle Scholar
  76. 76.
    A. Gole, C. Dash, V. Ramakrishnan, S.R. Sainkar, A.B. Mandale, M. Rao and M. Sastry,Langmuir, 2001,17, 1674CrossRefGoogle Scholar
  77. 77.
    A. Gole, S. Vyas, S. Phadtare, A. Lachke and M. Sastry,Colloids and Surfaces B: Biointerfaces, 2002,25, 129CrossRefGoogle Scholar
  78. 78.
    M. Yang J. Jiang, Y. Lu, Y. He, G. Shen and R. Yu,Biomaterials, 2007,28, 3408CrossRefGoogle Scholar
  79. 79.
    D. Du, S. Chen, J. Cai and A. Zhang,Biosens Bioelectron, 2007,23, 130CrossRefGoogle Scholar
  80. 80.
    L. Lu and X. Lin,Anal Sci, 2004,20, 527CrossRefGoogle Scholar
  81. 81.
    L. Tang, G.M. Zeng, G.L. Shen, Y.P. Li, Y. Zhang and D.L. Huang,Environ Sci Technol, 2008,42, 1207CrossRefGoogle Scholar
  82. 82.
    S. Andreescu and L.A. Luck,Anal Biochem, 2008,375, 282CrossRefGoogle Scholar
  83. 83.
    X.L. Luo, J.J. Xu, Q. Zhang, G.J. Yang and H.Y. Chen,Biosens Bioelectron, 2005,21, 190CrossRefGoogle Scholar
  84. 84.
    F. Patolsky, T. Gabriel and I. Willner,Journal of Electroanalytical Chemistry, 1999,479, 69CrossRefGoogle Scholar
  85. 85.
    Z.M. Liu, H. Wang, Y. Yang, H.F. Yang, S.Q. Hu, G.L. Shen and R.Q. Yu,Analytical Letters, 2004,37, 1079CrossRefGoogle Scholar
  86. 86.
    T. Yin, W. Wei, L. Yang, K. Liu and X. Gao,J Biochem Biophys Methods, 2007,70, 587CrossRefGoogle Scholar
  87. 87.
    C.X. Lei, S.Q. Hu, N. Gao, G.L. Shen and R.Q. Yu,Bioelectrochemistry, 2004,65, 33CrossRefGoogle Scholar
  88. 88.
    S. Zhao, K. Zhang, Y. Bai, W. Yang and C. Sun,Bioelectrochemistry, 2006,69, 158CrossRefGoogle Scholar
  89. 89.
    S. Zhang, N. Wang, H. Yu, Y. Niu and C. Sun,Bioelectrochemistry, 2005,67, 15CrossRefGoogle Scholar
  90. 90.
    X. Li, R. Yuan, Y. Chai, L. Zhang, Y. Zhuo and Y. Zhang,J Biotechnol, 2006,123, 356CrossRefGoogle Scholar
  91. 91.
    Y. Du, X.L. Luo, J.J. Xu and H.Y. Chen,Bioelectrochemistry, 2007,70, 342CrossRefGoogle Scholar
  92. 92.
    S. Li, R. Zhang, P. Li, W. Yi, Z. Zhang, S. Chen, S. Su, L. Zhao and C. Hu,Int Immunopharmacol, 2008,8, 859CrossRefGoogle Scholar
  93. 93.
    I. Robert, A. Reynolds, C.A. Mirkin and R.L. Letsinger,Journal of the American Chemical Society, 2000,122, 3795CrossRefGoogle Scholar
  94. 94.
    R. Jin, G. Wu, Z. Li, C.A. Mirkin and G.C. Schatz,J Am Chem Soc, 2003,125, 1643CrossRefGoogle Scholar
  95. 95.
    J. Kang, X. Li, G. Wu, Z. Wang and X. Lu,Anal Biochem, 2007,364, 165CrossRefGoogle Scholar
  96. 96.
    H. Cai, C. Xu, P. He and Y. Fang,Journal of Electroanalytical Chemistry, 2001,510, 78CrossRefGoogle Scholar
  97. 97.
    J. Li, T. Han, N. Wei, J. Du and X. Zhao,Biosensors and Bioelectronics 2009,25, 773CrossRefGoogle Scholar
  98. 98.
    Y. Wei, Y. Li, N. Zhang, G. Shi and L. Jin,Ultrason Sonochem, 2009,17, 17CrossRefGoogle Scholar
  99. 99.
    H. Wang, X. Wang, X. Zhang, X. Qin, Z. Zhao, Z. Miao, N. Huang and Q. Chen,Biosens Bioelectron, 2009,25, 142CrossRefGoogle Scholar
  100. 100.
    Y. Zhang, J. Wang and M. Xu,Colloids Surf B Biointerfaces, 2009, Article in PressGoogle Scholar
  101. 101.
    R. Cui, H. Huang, Z. Yin, D. Gao and J.J. Zhu,Biosens Bioelectron, 2008,23, 1666CrossRefGoogle Scholar
  102. 102.
    M. Valden, X. Lai and D.W. Goodman,Science, 1998,281, 1647CrossRefGoogle Scholar
  103. 103.
    Y. Lou, M.M. Maye, L. Han, J. Luo and C.-J. Zhong,Chemical Communications, 2001, 473Google Scholar
  104. 104.
    M.S. El-Deab, T. Okajima and T. Ohsaka,Journal of The Electrochemical Society 2003,150, A851CrossRefGoogle Scholar
  105. 105.
    Q. Kang, L. Yang and Q. Cai,Bioelectrochemistry, 2008,74, 62CrossRefGoogle Scholar
  106. 106.
    Y. Kong, H. Chen, Y. Wang and S.A. Soper,Electrophoresis, 2006,27, 2940CrossRefGoogle Scholar
  107. 107.
    A.I. Abdelrahman, A.M. Mohammad, T. Okajima and T. Ohsaka,J Phys Chem B, 2006,110, 2798CrossRefGoogle Scholar
  108. 108.
    G. Liu, Y.Y. Lin, H. Wu and Y. Lin,Environ Sci Technol, 2007,41, 8129CrossRefGoogle Scholar
  109. 109.
    N. Zhou, J. Wang, T. Chen, Z. Yu and G. Li,Anal Chem, 2006,78, 5227CrossRefGoogle Scholar
  110. 110.
    A.P. Alivisatos,Science, 1996,271, 933CrossRefGoogle Scholar
  111. 111.
    M.M. Maye, Y. Lou and C.J. Zhong,Langmuir, 2000,16, 7520CrossRefGoogle Scholar
  112. 112.
    M. Haruta and M. Daté,Applied Catalysis A: General, 2001,222, 427CrossRefGoogle Scholar
  113. 113.
    M. Turner, V.B. Golovko, O.P. Vaughan, P. Abdulkin, A. Berenguer-Murcia, M.S. Tikhov, B.F. Johnson and R.M. Lambert,Nature, 2008,454, 981CrossRefGoogle Scholar
  114. 114.
    C.R. Raj and B.K. Jena, Chem Commun (Camb), 2005, 2005Google Scholar
  115. 115.
    B.K. Jena and C.R. Raj,Anal Chem, 2006,78, 6332CrossRefGoogle Scholar
  116. 116.
    M. Zhu, M. Liu, G. Shi, F. Xu, X. Ye, J. Chen, L. Jin and J. Jin,Analytica Chimica Acta, 2002,455, 199CrossRefGoogle Scholar
  117. 117.
    A. Yu, Z. Liang, J. Cho and F. Caruso,Nano Letters, 2003,3, 1203CrossRefGoogle Scholar
  118. 118.
    S. Bharathi and M. Nogami,Analyst, 2001,126, 1919CrossRefGoogle Scholar
  119. 119.
    B.K. Jena and C.R. Raj,Chemistry, 2006,12, 2702CrossRefGoogle Scholar
  120. 120.
    C.R. Raj, T. Okajima and T. Ohsaka,J. Electroanal. Chem., 2003,543, 127CrossRefGoogle Scholar
  121. 121.
    J. Wang, D. Xu, A.N. Kawde and R. Polsky,Anal Chem, 2001,73, 5576CrossRefGoogle Scholar
  122. 122.
    L. Authier, C. Grossiord, P. Brossier and B. Limoges,Anal Chem, 2001,73, 4450CrossRefGoogle Scholar
  123. 123.
    M. Dequaire, C. Degrand and B. Limoges,Anal Chem, 2000,72, 5521CrossRefGoogle Scholar
  124. 124.
    J.D. Qiu, H.Z. Peng, R.P. Liang, J. Li and X.H. Xia,Langmuir, 2007,23, 2133CrossRefGoogle Scholar
  125. 125.
    J. Li and X.Q. Lin,Anal Chim Acta, 2007,596, 222CrossRefGoogle Scholar
  126. 126.
    B.Y. Wu, S.H. Hou, F. Yin, Z.X. Zhao, Y.Y. Wang, X.S. Wang and Q. Chen,Biosens Bioelectron, 2007,22, 2854CrossRefGoogle Scholar
  127. 127.
    S. Xu, G. Tu, B. Peng and X. Han,Anal Chim Acta, 2006,570, 151CrossRefGoogle Scholar
  128. 128.
    S. Upadhyay, G.R. Rao, M.K. Sharma, B.K. Bhattacharya, V.K. Rao and R. Vijayaraghavan,Biosens Bioelectron, 2009,25, 832CrossRefGoogle Scholar
  129. 129.
    L. Lin, H. Zhao, J. Li, J. Tang, M. Duan and L. Jiang,Biochem Biophys Res Commun, 2000,274, 817CrossRefGoogle Scholar
  130. 130.
    X.C. Zhou, S.J. O’shea and S.F.Y. Li,Chemical Communications, 2000, 953Google Scholar
  131. 131.
    H.Q. Zhao, L. Lin, J.R. Li, J.A. Tang, M.X. Duan and L. Jiang,Journal of Nanoparticle Research, 2001,3, 321CrossRefGoogle Scholar
  132. 132.
    Z. Hongqiu, L. Lin, T. Ji, D. Mingxing and J. Long,Chinese Science Bulletin, 2001,46, 1074CrossRefGoogle Scholar
  133. 133.
    T. Liu, J. Tang and L. Jiang,Biochem Biophys Res Commun, 2002,295, 14CrossRefGoogle Scholar
  134. 134.
    T. Liu, J. Tang and L. Jiang,Biochemical and Biophysical Research Communications, 2004,313, 4Google Scholar
  135. 135.
    L. Pang, J. Li, J. Jiang, G. Shen and R. Yu,Anal Biochem, 2006,358, 99CrossRefGoogle Scholar
  136. 136.
    Y. Weizmann, F. Patolsky and I. Willner,Analyst, 2001,126, 1502CrossRefGoogle Scholar
  137. 137.
    I. Willner, F. Patolsky, Y. Weizmann and B. Willner,Talanta, 2002,56, 847CrossRefGoogle Scholar
  138. 138.
    S.H. Chen, V.C. Wu, Y.C. Chuang and C.S. Lin,J Microbiol Methods, 2008,73, 7CrossRefGoogle Scholar
  139. 139.
    X. Chu, Z.L. Zhao, G.L. Shen and R.Q. Yu,Sensors and Actuators B, 2006,114, 696CrossRefGoogle Scholar
  140. 140.
    N.H. Kim, T.J. Baek, H.G. Park and G.H. Seong,Anal Sci, 2007,23, 177CrossRefGoogle Scholar
  141. 141.
    Z.D. Liu, Y. F. Li, J. Ling and C.Z. Huang,Environ Sci Technol, 2009,43, 5022CrossRefGoogle Scholar
  142. 142.
    Q. Zhang, Y. Huang, R. Zhao, G. Liu and Y. Chen,J Colloid Interface Sci, 2008,319, 94CrossRefGoogle Scholar
  143. 143.
    Y. Ding, J. Liu, H. Wang, G. Shen and R. Yu,Biomaterials, 2007,28, 2147CrossRefGoogle Scholar
  144. 144.
    Y. Zhang, H. Wang, B. Yan, Y. Zhang, J. Li, G. Shen and R. Yu,Journal of Immunological Methods, 2008,332, 103CrossRefGoogle Scholar

Copyright information

© World Gold Council 2010

Authors and Affiliations

  • Yuanyuang Li
    • 1
  • Hermann J. Schluesener
    • 2
  • Shunqing Xu
    • 1
  1. 1.Key Lab of Environment and Health, School of Public Health, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Institute of Brain ResearchHospital of Tuebingen UniversityTuebingenGermany

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