Gold Bulletin

, Volume 29, Issue 3, pp 87–93 | Cite as

Gold drugs: Mechanism of action and toxicity

  • Sabine L Best
  • Peter J Sadler
Open Access
Article

Abstract

Gold drugs are still amongst the most efficacious for the treatment of rheumatoid arthritis. Their mechanism of action, as well as the molecular basis of their side-effects, remain poorly understood. Current theories are reviewed, including recent potential breakthroughs. The interaction of gold(III) with peptides and proteins and its immunochemical implications are discussed.

References

  1. 1.
    P. J. Sadler,Adv. Inorg. Chem., 1991,36, 1CrossRefGoogle Scholar
  2. 2.
    G. Sava, in ‘Metal Compounds in Cancer Therapy’, ed. S.P. Fricker, Chapman and Hall, London, 1994, p.65Google Scholar
  3. 3.
    G.D. Champion, G.G. Graham and J.B. Ziegler,Baillieres Clin. Rbeumatol., 1990,4, 491CrossRefGoogle Scholar
  4. 4.
    L. Treagan,Metal Ions in Biol. Syst., 1983,16, 27Google Scholar
  5. 5.
    I. Schröter and J. Strähle,Chem. Ber., 1991,124, 2161CrossRefGoogle Scholar
  6. 6.
    J.L. Abruzzo and R.J. DeHoratius,Am. J Trop. Med. Hyg., 1969,18, 506Google Scholar
  7. 7.
    R.E. Thomas and R.A. Papandrea,Med. J Austral., 1993,158, 720Google Scholar
  8. 8.
    T. Okada, B.K. Patterson, S.-Q. Ye and M.E. Gurney,Virology, 1993,192, 631CrossRefGoogle Scholar
  9. 9.
    R.C Elder, Z. Zhao, Y Zhang, J.G. Dorsey, E.V. Hess and K.J. Tepperman,J Rheumatol., 1993,20, 268Google Scholar
  10. 10.
    Y.F. Zhang, E.V. Hess, K.G. Pryhuber, J.G. Dorsey, K. Tepperman and R.C Elder,Inorg. Chim. Acta, 1995,229, 271CrossRefGoogle Scholar
  11. 11.
    G.W. Rafter, J. Inorg.Biocbem., 1990,38, 261Google Scholar
  12. 12.
    C.W. Mahoney, C.E. Hensey, and A. Azzi,Biochem. Pharmacol., 1989,38, 3383CrossRefGoogle Scholar
  13. 13.
    T. Herlin, K. Fogh, N.O. Christiansen and K. Kragballe,Agents and Actions, 1989,28, 121CrossRefGoogle Scholar
  14. 14.
    P. E. McGowan, J.M. Campbell, J. Reglinski and W.E. Smith,Inorg. Chim. Acta, 1993,210, 1CrossRefGoogle Scholar
  15. 15.
    M.L. Handel, A. deFazio, C.K.W Watts, R.O. Day and R.L. Sutherland,Mol. Pharmacol., 1991,40, 613Google Scholar
  16. 16.
    R. Rudkowski, G.G. Graham, G.D. Champion and J.B. Ziegler,Biochem. Pharmacol., 1990,39, 1687CrossRefGoogle Scholar
  17. 17.
    G.G. Graham, J.R. Bales, M.C Groorveld and P.J. Sadler,J. Inorg. Biochem., 1985,25, 163CrossRefGoogle Scholar
  18. 18.
    G.G. Graham, T.M. Haavisto, P.J. McNaught, C.D. Browne, and G.D. Champion,J. Rheumatol., 1982,9, 527Google Scholar
  19. 19.
    G. Salmeron and P.E. Lipsky,J. Rbeumatol. Suppl., 1982,8, 25Google Scholar
  20. 20.
    P.E. Lipsky and M. Ziff,J. Clin. Invest., 1977,59, 455CrossRefGoogle Scholar
  21. 21.
    P. Romagnoli, G.A. Spinas and F. Sinigaglia,J. Clin. Lnvest, 1992,89, 254CrossRefGoogle Scholar
  22. 22.
    F. Sinigaglia,J. Invest. Dermatol., 1994,102, 398CrossRefGoogle Scholar
  23. 23.
    P. Griem, K. Takahashi, H. Kalbacher and E. Gleichmann,J. Immunol., 1995,155, 1575Google Scholar
  24. 24.
    P. Griem and E. Gleichmann,Curr. Opin. Immunol., 1995,7, 831CrossRefGoogle Scholar
  25. 25.
    P.J. Sadler,Gold. Bull., 1976,9, 110Google Scholar
  26. 26.
    26 D.H. Brown and W.E. Smith,Chem. Soc. Rev., 1980,9, 217CrossRefGoogle Scholar
  27. 27.
    P.J. Sadler and R.E. Sue,Metal-Based Drugs, 1994,1, 107CrossRefGoogle Scholar
  28. 28.
    C.F. Shaw III,Inorg. Perspect. BioI. Med., 1979,2, 287Google Scholar
  29. 29.
    C.F. Shaw III,Comments Inorg. Chem., 1989,8, 233CrossRefGoogle Scholar
  30. 30.
    A.J. Lewis and D.T. Walz,Prog. Med. Chem., 1982,19, 1CrossRefGoogle Scholar
  31. 31.
    C.F. Shaw III, A.A. Isab, M.T. Coffer and C. Mirabelli,Biochem. Pharmacol., 1990,40, 1227CrossRefGoogle Scholar
  32. 32.
    O.M. Ni Dhubhghaill, P.J. Sadler and A. Tucker,J. Am. Chem. Soc., 1992,114, 1118CrossRefGoogle Scholar
  33. 33.
    J. Christodoulou, P.J. Sadler and A. Tucker,Eur. J. Biochem., 1994,225, 363CrossRefGoogle Scholar
  34. 34.
    J.R. Roberts, J. Xiao, B. Schliesman, D.J. Parsons and C.F. Shaw III,Inorg. Chem., 1996,35, 424CrossRefGoogle Scholar
  35. 35.
    J. Christodoulou, P.J. Sadler and A. Tucker,FEBS Letters, 1995,376, 1CrossRefGoogle Scholar
  36. 36.
    D. Schuhmann, M. Kubickamuranyi, J. Mirtschewa, J. Gunther, P. Kind and E. Gleichmann,J. Immunol., 1990,145, 2132Google Scholar
  37. 37.
    J. Verwilghen, G.H. Kingsley, L. Gambling and G.S. Panayi,Arthritis Rheum., 1992,35, 1413CrossRefGoogle Scholar
  38. 38.
    P. Griem, K. Panrhel, H. Kalbacher and E. Gleichmann,Eur J Immunol., 1996,26, 279CrossRefGoogle Scholar
  39. 39.
    B. Beverly and D. Couri,Fed. Proc., 1987,46, 854Google Scholar
  40. 40.
    C.F. Shaw III, S. Schraa, E. Gleichmann, Y.P. Grover, L. Dunemann and A. Jagarlamudi,Metal Based Drugs, 1994,1, 351CrossRefGoogle Scholar
  41. 41.
    T.L. Blundell and L.N. Johnson, ‘Protein Crystallography’, Academic Press, New York, 1976Google Scholar
  42. 42.
    P.L. Witkiewicz and C.F. Shaw III,Chem. Commun., 1981, 1111Google Scholar
  43. 43.
    D.H. Brown and W.E. Smith,Am. Chem. Soc. Symp. Ser., 1983,209, 401Google Scholar
  44. 44.
    W.E. Smith and J. Reglinski,Perspec. Bioinorg. Chem., 1991,1, 183Google Scholar
  45. 45.
    C.F. Shaw III, M.P. Cancro, P.L. Witkiewicz and J.E. Eldridge,Inorg. Chem., 1980,19, 3198CrossRefGoogle Scholar
  46. 46.
    E. Bordignon, L. Cattalini, G. Natile and A. Scatturin,Chem. Commun., 1973, 878Google Scholar
  47. 47.
    G. Natile, E. Bordignon and L. Catralini,Inorg. Chem., 1976,15, 246CrossRefGoogle Scholar
  48. 48.
    A.A. Isab and P.J. Sadler,Biochim. Biophys. Acta, 1977,492, 322Google Scholar
  49. 49.
    M. Wienken, B. Lippert, E. Zangrando and L. Randaccio,Inorg. Chem., 1992,31, 1983CrossRefGoogle Scholar
  50. 50.
    S.L. Best., TK. Chattopadhyay, M.I. Djuran, R.A. Palmer, P.J. Sadler, I. Sóvágó and K. Varnagy, in preparationGoogle Scholar
  51. 51.
    S.L. Best, M.I. Djuran and P.J. Sadler, In preparationGoogle Scholar
  52. 52.
    R.J. Sundberg and R.B. Martin,Chem. Rev., 1974,74, 471CrossRefGoogle Scholar
  53. 53.
    R.J. Sundberg and G. Gupta,Bioinorg. Chem., 1973,3, 39CrossRefGoogle Scholar
  54. 54.
    W.J. Eilbeck and M.S. West,J. Chem. Soc., Dalton Trans., 1976, 274Google Scholar
  55. 55.
    C.A. Evans, D.L. Rabenstein, G. Geier and I.W. Erni,J. Am. Chem. Soc., 1977,99, 8106CrossRefGoogle Scholar
  56. 56.
    T.P. Pitner, E.W. Wilson and R.B. Martin,Inorg. Chem., 1972,11, 738CrossRefGoogle Scholar

Copyright information

© World Gold Council 1996

Authors and Affiliations

  • Sabine L Best
    • 1
  • Peter J Sadler
    • 1
  1. 1.Department of Chemistry, Birkbeck CollegeUniversity of London, Gordon House and Christopher Ingold LaboratoriesLondonUK

Personalised recommendations