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Journal of NeuroVirology

, Volume 16, Issue 6, pp 466–471 | Cite as

Negative association of Epstein-Barr virus or herpes simplex virus-1 with tumefactive central nervous system inflammatory demyelinating disease

  • Takao Kiriyama
  • Hiroshi KataokaEmail author
  • Takahiko Kasai
  • Akitaka Nonomura
  • Satoshi Ueno
Short Communication

Abstract

Central nervous system (CNS) demyelination has been suggested to be associated with infections caused by the Epstein-Barr virus (EBV) or herpes simplex virus (HSV)-1. CNS inflammatory demyelinating disease (IDD) rarely presents as a large lesion. We evaluated samples of serum and cerebrospinal fluid (CSF) by enzyme-linked immunosorbent assay to detect recent infection with these viruses and analyzed CSF and brain specimens by polymerase chain reaction (PCR) or immunohistochemical studies for evidence of these viruses in three patients with biopsy-proven CNS IDD. The results of PCR tests for EBV and HSV in CSF or brain specimens were negative. Elevated anti-EBV or -HSV antibody levels were not found in serum or CSF in any patient. Immunohistochemical studies showed that IDD lesions were negative for latent membrane protein (LMP)-1, Epstein-Barr nuclear antigen (EBNA)-2, and EBNA noncoding RNA (EBER)-1. These results suggest a negative association between CNS IDD and EBV or HSV.

Keywords

Epstein-Barr virus herpes simplex virus inflammatory demyelinating disease multiple sclerosis viral infection 

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References

  1. Ascherio A, Munger KL, Lennette ET, Spiegelman D, Hernán MA, Olek MJ, Hankinson SE, Hunter DJ (2001). Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study.JAMA 286: 3083–3088.CrossRefPubMedGoogle Scholar
  2. Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Séguin C (1984). DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Nature 310: 207–211.CrossRefPubMedGoogle Scholar
  3. Burgoon MP, Cohrs RJ, Bennett JL, Anderson SW, Ritchie AM, Cepok S, Hemmer B, Gilden D, Owens GP (2009). Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis.Ann Neurol 65: 474–479.CrossRefPubMedGoogle Scholar
  4. Cao M, Xiao X, Egbert B, Darragh TM, Yen TS (1989). Rapid detection of cutaneous herpes simplex virus infection with the poly merase chain reaction.J Invest Dermatol 92: 391–392.CrossRefPubMedGoogle Scholar
  5. Dagher AP, Smirniotopoulos J (1996). Tumefactive demyelinating lesions.Neuroradiology 38: 560–565.CrossRefPubMedGoogle Scholar
  6. Drago L, Lombardi A, De Vecchi E, Giuliani G, Bartolone R, Gismondo MR (2004). Comparison of nested PCR and real time PCR of Herpesvirus infections of central nervous system in HIV patients.BMC Infect Dis 30: 55.CrossRefGoogle Scholar
  7. Franciotta D, Salvetti M, Lolli F, Serafini B, Aloisi F (2008). B cells and multiple sclerosis.Lancet Neurol 7: 852–858.CrossRefPubMedGoogle Scholar
  8. Hart MN, Earle KM (1975). Haemorrhagic and perivenous encephalitis: a clinical pathological review of 38 cases.J Neurol Neurosurg Psychiatry 38: 585–591.CrossRefPubMedGoogle Scholar
  9. Kepes JJ (1993). Large focal tumor-like demyelinating lesions of the brain: intermediate entity between multiple sclerosis and acute disseminated encephalomyelitis? A study of 31 patients.Ann Neurol 33: 18–27.CrossRefPubMedGoogle Scholar
  10. Kimura H, Wang Y, Pesnicak L, Cohen JI, Hooks JJ, Straus SE, Williams RK (1998). Recombinant varicella-zoster virus glycoproteins E and I: immunologic responses and clearance of virus in a guinea pig model of chronic uveitis.J Infect Dis 178: 310–317.CrossRefPubMedGoogle Scholar
  11. Martin JR, Holt RK, Webster HD (1988). Herpes-simplexrelated antigen in human demyelinative disease and encephalitis.Acta Neuropathol 76: 325–337.CrossRefPubMedGoogle Scholar
  12. Menge T, Hemmer B, Nessler S, Wiendl H, Neuhaus O, Hartung HP, Kieseier BC, Stüve O (2005). Acute disseminated encephalomyelitis: an update.Arch Neurol 62: 1673–1680.CrossRefPubMedGoogle Scholar
  13. Okada Y, Sawa H, Endo S, Orba Y, Umemura T, Nishihara H, Stan AC, Tanaka S, Takahashi H, Nagashima K (2002). Expression of JC virus agnoprotein in progressive multifocal leukoencephalopathy brain.Acta Neuropathol 104: 130–136.CrossRefPubMedGoogle Scholar
  14. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, Lublin FD, Metz LM, McFarland HF, O’Connor PW, Sandberg-Wollheim M, Thompson AJ, Weinshenker BG, Wolinsky JS (2005). Diagnostic criteria for multiple sclerosis: 2005 revisions to the “McDonald Criteria.”Ann Neurol 58: 840–846.CrossRefPubMedGoogle Scholar
  15. Serafini B, Rosicarelli B, Franciotta D, Magliozzi R, Reynolds R, Cinque P, Andreoni L, Trivedi P, Salvetti M, Faggioni A, Aloisi F (2007). Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain.J Exp Med 204: 2899–2912.CrossRefPubMedGoogle Scholar
  16. Sonneville R, Klein I, de Broucker T, Wolff M (2009). Postinfectious encephalitis in adults: diagnosis and management.J Infect 58: 321–328.CrossRefPubMedGoogle Scholar
  17. Torkildsen Ø, Nyland H, Myrmel H, Myhr KM (2008). Epstein-Barr virus reactivation and multiple sclerosis.Eur J Neurol 15: 106–108.PubMedGoogle Scholar
  18. Willis SN, Stadelmann C, Rodig SJ, Caron T, Gattenloehner S, Mallozzi SS, Roughan JE, Almendinger SE, Blewett MM, Brück W, Hafler DA, O’Connor KC (2009). Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain.Brain 132:3318–33288.CrossRefPubMedGoogle Scholar

Copyright information

© Journal of NeuroVirology 2010

Authors and Affiliations

  • Takao Kiriyama
    • 1
  • Hiroshi Kataoka
    • 1
    Email author
  • Takahiko Kasai
    • 2
  • Akitaka Nonomura
    • 2
  • Satoshi Ueno
    • 1
  1. 1.Department of NeurologyNara Medical UniversityKashiharaJapan
  2. 2.Department of Diagnostic PathologyNara Medical UniversityKashihara, NaraJapan

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