Factor XI (FXI) deficiency is a hereditary coagulation disorder observed in various mammalian species. The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of theFXI gene. Because the disorder seems to have an impact on reproductive traits and udder health in cattle, we tested 103 randomly selected cows, 28 cows with repeat breeding, and 9 cows with recurrent mastitis for the presence of an abnormalFXI allele. Three related cows were diagnosed as carriers.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Brush PJ, Anderson PH, Gunning RF, 1987. Identification of factor XI deficiency in Holstein Friesian cattle in Britain. Vet Rec 121: 14–17.
Dodds WJ, Kull JE, 1971. Canine factor XI (plasma thromboplastin antecedent) deficiency. J Lab Clin Med 78: 746–752.
Gentry PA, Downie HG, 1977. Blood coagulation. In: Swenson MJ ed. Duke’s physiology of domestic animals, 9th ed. Cornell University Press, Ithaca, NY.
Gentry PA, Black WD, 1980. Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle. J Dairy Sci 63: 616–620.
Gentry PA, Crane S, Lotz F, 1975. Factor XI (plasma thromboplastin antecedent) deficiency in cattle. Can Vet J 16: 160–163.
Gentry PA, Overton KM, Robinson JL, 1996. Bovine factor XI deficiency. Illinois Dairy Report: 32–35.
Gentry PA, Ross ML, 1994. Coagulation factor XI deficiency in Holstein cattle: expression and distribution of factor XI activity. Can J Vet Res 58: 242–247.
Gentry PA, Ross ML, 1986. Failure of routine coagulation screening tests to detect heterozygous state of bovine factor XI deficiency. Vet Clin Pathol 15: 12–16.
Ghanem ME, Nishibori M, Nakao T, Nakatani K, Akita M, 2005. Factor XI mutation in a Holstein cow with repeat breeding in Japan. J Vet Med Sci 67: 713–715.
Kociba GJ, Ratnoff OD, Loeb WF, Wall RL, Heider LE, 1969. Bovine thromboplastin antecedent (factor XI) deficiency. J Lab Clin Med 74: 37–41.
Liptrap RM, Gentry PA, Ross ML, Cummings E, 1995. Preliminary findings of altered follicular activity in Holstein cows with coagulation factor XI deficiency. Vet Res Commun 19: 463–471.
Marron BM, Robinson JL, Gentry PA, Beever JE, 2004. Identification of a mutation associated with factor XI deficiency in Holstein cattle. Anim Genet 35: 454–456.
Mukhopadhyaya PN, Jha M, Muraleedharan P, Gupta RR, Rathod RN, Mehta HH, Khoda VK, 2006. Simulation of normal, carrier and affected controls for large-scale genotyping of cattle for factor XI deficiency. Genet Mol Res 5: 323–332.
Rosenthal RL, Dreskin OH, Rosenthal N, 1953. New hemophilia-like disease caused by deficiency of a third plasma thromboplastin factor. Proc Soc Exp Biol Med 82: 171–174.
About this article
Cite this article
Gurgul, A., Rubiś, D. & Słota, E. Identification of carriers of the mutation causing coagulation factor XI deficiency in Polish Holstein-Friesian cattle. J Appl Genet 50, 149–152 (2009). https://doi.org/10.1007/BF03195666
- factor XI deficiency
- Polish Holstein-Friesian cattle