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Journal of Applied Genetics

, Volume 49, Issue 1, pp 69–74 | Cite as

Associations between 2 paternal casein haplotypes and milk yield traits of Swiss Fleckvieh cattle

  • Martin H. BraunschweigEmail author
Original Article

Abstract

Associations between casein haplotypes and milk yield traits of offspring from 5 Swiss Fleckvieh AI test bulls were investigated. The analysis was performed by using a daughter design, where each daughter inherited either paternal haplotype B-A1-A-A or B-A2-A-A for alleles of αs1-, β-, αs2- and κ-casein genes. The substitution effects of paternalCSN2 A1 versus A2 on protein yield deviations (YDs) were significant (P < 0.05), whereas their effects on milk and fat YDs were not. The paternal substitution effects of theCSN2 A1 versus the A2 allele on protein YDs within the 5 sires did not reach the significance level. This is due to the contrary allele substitution effect of a sire compared to the other 4 sires. The effects of maternal haplotypes on milk, protein and fat YDs were not significant. However, it is noteworthy that the effects of haplotypes with a low frequency in the population deviate largely from the most frequent haplotype B-A2-A-A. The effects of β-lactoglobulin (BLG) genotypes were significant for protein YDs but not for milk and fat YDs. The association between the paternalCSN2 A1 and A2 alleles and milk protein YDs within sires but not milk and fat YDs indicate an interaction, which might be a consequence ofCSN2 heterogeneity or a closely linked gene that is contributing to the estimated effects.

Keywords

casein haplotype daughter design genetic variant milk yield trait Swiss Fleckvieh cattle 

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References

  1. Aleandri R, Buttazzoni LG, Schneider JC, Caroli A, Davoli R, 1990. The effect of milk protein polymorphisms on milk components and cheese-producing ability. J Dairy Sci 73: 241–255.CrossRefGoogle Scholar
  2. Aschaffenburg R, Drewry J, 1955. Occurrence of different beta-lactoglobulins in cow’s milk. Nature 176: 218–219.CrossRefPubMedGoogle Scholar
  3. Boettcher PJ, Caroli A, Stella A, Chessa S, Budelli E, Canavesi F, et al. 2004. Effects of casein haplotypes on milk production traits in Italian Holstein and Brown Swiss cattle. J Dairy Sci 87: 4311–4317.CrossRefPubMedGoogle Scholar
  4. Bovenhuis H, van Arendonk JAM, Korver S, 1992. Associations between milk protein polymorphisms and milk production traits. J Dairy Sci 75: 2549–2559.CrossRefPubMedGoogle Scholar
  5. Braunschweig M, Hagger C, Stranzinger G, Puhan Z, 2000. Associations between casein haplotypes and milk production traits of Swiss Brown cattle. J Dairy Sci 83: 1387–1395.CrossRefPubMedGoogle Scholar
  6. Braunschweig MH, Leeb T, 2006. Aberrant low expression level of bovine β-lactoglobulin is associated with a C to A transversion in theBLG promoter region. J Dairy Sci 89: 4414–4419.CrossRefPubMedGoogle Scholar
  7. Cohen-Zinder M, Seroussi E, Larkin DM, Loor JJ, Everts-van der Wind A, Lee JH, et al. 2005. Identification of a missense mutation in the bovineABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle. Genome Res 15: 936–944.CrossRefPubMedGoogle Scholar
  8. Ferretti L, Leone P, Sgaramella V, 1990. Long range restriction analysis of the bovine casein gene. Nucl Acids Res 18: 6829–6833.CrossRefPubMedGoogle Scholar
  9. Geldermann H, Pieper U, Roth B, 1985. Effects of marked chromosome sections on milk performance in cattle. Theor Appl Genet 70: 138–146.Google Scholar
  10. Grosclaude F, 1988. Le polymorphisme génétique des principales lactoprotéines bovines. INRA Prod Anim 1: 5–17.Google Scholar
  11. Ikonen T, Bovenhuis H, Ojala M, Ruottinen O, Georges M, 2001. Associations between casein haplotypes and first lactation milk production traits in Finnish Ayrshire cows. J Dairy Sci 84: 507–514.CrossRefPubMedGoogle Scholar
  12. Khatkar MS, Thomson PC, Tammen I, Raadsma HW, 2004. Quantitative trait loci mapping in dairy cattle: review and meta-analysis. Genet Sel Evol 36: 163–190.CrossRefPubMedGoogle Scholar
  13. Khatkar MS, Zenger KR, Hobbs M, Hawken RJ, Cavanagh JA, Barris W, et al. 2006. A first-generation metric linkage disequilibrium map of bovine chromosome 6. Genetics 174: 79–85.CrossRefPubMedGoogle Scholar
  14. Lien S, Rogne S, Brovold M J, Alestrom P, 1990. A method for isolation of DNA from frozen (A.I.) bulls semen. J Anim Breed Genet 107: 74.CrossRefGoogle Scholar
  15. Lien S, Gomez Raya L, Steine, T, Fimland E, Rogne S, Raya LG, 1995. Associations between casein haplotypes and milk yield traits, J Dairy Sci 78: 2047–2056.CrossRefPubMedGoogle Scholar
  16. Ng-Kwai-Hang KF, Hayes JF, Moxley JE, Monardes HG, 1987. Variation in milk protein concentrations associated with genetic polymorphism and environmental factors. J Dairy Sci 70: 563–570.CrossRefPubMedGoogle Scholar
  17. SAS Institute Inc. SAS/STAT®, 1990. User’s guide. Release 6.03 Edition, Cary, NC, USA.Google Scholar
  18. Schlee P, Rottmann O, Buchberger J, Graml R, Aumann J, Binser R, Pirchner F, 1992. Milk protein genes of the German Simmental bull “Haxl” and their effect on allele frequencies. Züchtungskunde 64: 312–322.Google Scholar
  19. Schlieben S, Erhardt G, Senft B, 1991. Genotyping of bovine K-casein (K-CnA, κ-CnB, κ-CnC, κ-CnE) following DNA sequence amplification and direct sequencing of κ-CNE PCR product. Anim Genet 22: 333–342.CrossRefPubMedGoogle Scholar
  20. Schnabel RD, Kim J-J, Ashwell MS, Sonstegard TS, van Tassell CP, Connor EE, Taylor JF, 2005. Fine-mapping milk production quantitative trait loci on BTA6: Analysis of the bovine osteopontin gene. Proc Natl Acad Sci USA 102: 6896–6901.CrossRefPubMedGoogle Scholar
  21. Seibert B, Erhardt G, Senft B, 1985. Procedure for simultaneous phenotyping of genetic variants in cow’s milk by isoelectric focusing. Anim Blood Groups Biochem Genet 16: 183–191.CrossRefPubMedGoogle Scholar
  22. Threadgill DW, Womack JE, 1990. Genomic analysis of the major bovine milk protein genes. Nucl Acids Res 18: 6935–6942.CrossRefPubMedGoogle Scholar
  23. Velmala RJ, Vilkki HJ, Elo KT, de Koning DJ, Mäki-Tanila AV, 1999. A search for quantitative trait loci for milk production traits on chromosome 6 in Finnish Ayrshire cattle. Anim Genet 30: 136–143.CrossRefPubMedGoogle Scholar
  24. Weller JI, Kashi Y, Soller M, 1990. Power of daughter and granddaughter designs for determining linkage between marker loci and quantitative trait loci in dairy cattle. J Dairy Sci 73: 2525–2537.CrossRefPubMedGoogle Scholar
  25. Van Raden PM, Wiggans GR, 1991. Derivation, calculation, and use of national animal model information. J Dairy Sci 74: 2737–2746.CrossRefGoogle Scholar

Copyright information

© Institute of Plant Genetics, Polish Academy of Sciences, Poznan 2008

Authors and Affiliations

  1. 1.Institute of GeneticsVetsuisse Faculty, University of BerneBerneSwitzerland

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