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Importance of sustained high glucose condition in the development of diabetic osteopenia: Possible involvement of the polyol pathway

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References

  1. 1.

    Schneider LE, Schedl HP. Diabetes and intestinal calcium absorption in the rat. Am J Physiol 1972;223:1319–23.

  2. 2.

    Rumenapf G, Issa S, Schwille PO. The influence of progressive hyperinsulinemia of duodenal calcium absorption in the rat. Metabolism 1987;36:60–5.

  3. 3.

    Lemann J Jr, Lennon EJ, Piering WR, Prien EL Jr, Ricinati ES. Evidence that glucose ingestion inhibits net renal tubular reabsorption of calcium and magnesium in man. J Lab Clin Med 1970;75:578–85.

  4. 4.

    Albright F, Reifenstein EC. Parathyroid glands and metabolic bone disease: selected studies. Baltimore: Williams and Wilkins, 1948:150–60.

  5. 5.

    Levin ME, Boisseau VC, Avioli LV. Effect of diabetes mellitus on bone mass in juvenile and adult onset diabetes. N Engl J Med 1976;294:241–4.

  6. 6.

    Wu K, Schubeck KE, Frost HM. Haversian bone formation rates determined by a new method in human diabetes and osteoporosis. Calcif Tissue Res 1970;6:204–19.

  7. 7.

    Hough S, Avioli LV, Bergfeld MA, Fallon MD, Slatopolsky E, Teitelbaum SL. Correction of abnormal bone and mineral metabolism in chronic streptozotocin-induced diabetes mellitus in the rat by insulin therapy. Endocrinology 1981;108:2228–34.

  8. 8.

    Okuno Y, Nishizawa Y, Sekiya K, Hagiwara S, Miki T, Morii H. Total and regional bone mineral content in patients with non-insulin dependent diabetes mellitus. J Nutr Sci Vitaminol (Suppl) 1991;37:S43–9.

  9. 9.

    Imura H, Seino Y, Nakagawa S, Goto Y, Kosaka K, Sakamoto N, et al. Diabetic osteopenia in Japanese: a geographic study. J Jpn Diabetes Soc 1987;30:9924–9.

  10. 10.

    McNair P, Madsbad S, Christiansen C, Christiansen MS, Faber OK, Binder C, Transbol I. Bone loss in diabetes: effects of metabolic state. Diabetologia 1979;17:283–6.

  11. 11.

    McNair P, Madsbad S, Christiansen C. Bone mineral loss in insulin treated diabetes mellitus: studies on pathogenesis. Acta Endocrinol 1979;90:463–72.

  12. 12.

    Gallagher JC, Melton LJ, Riggs BL. Examination of prevalence rates of possible risk factors in a population with a fracture of the proximal femur. Clin Orthop 1980;153:158–65.

  13. 13.

    Raskin P, Stevenson MR, Barilla DE, Pak CY. The hypercalciuria of diabetes mellitus: its amelioration with insulin. Clin Endocrinol 1978;9:329–35.

  14. 14.

    Silberberg R. The skeleton in diabetes mellitus: a review of the literature. Diabetes Res 1986;3:329–38.

  15. 15.

    Klein M, Frost HM. The numbers of bone resoprtion and formation in rib. Henry Ford Hos Med Bull 1964;12:527–36.

  16. 16.

    Rico H, Hernandez ER, Cabranes JA, Gomez-Castresana F. Suggestion of a deficient osteoblastic function in diabetes mellitus: the possible cause of osteopenia in diabetics. Calcif Tissue Int 1989;45:71–3.

  17. 17.

    Palmeri E, Pedrazzoni M, Malaquinoo AM, Carapezzi C, Carbognani A, Maroni L. Osteocalcin levels in diabetes mellitus. In: Christiansen C, Arnaud CD, Parfitt AM, Peck WA, Riggs L, editors. Osteoporosis. Denmark: Aalborg Stiftsbogtrykkeri, 1984: 809–10.

  18. 18.

    Ishida H, Seino Y, Taminato T, Usami M, Takeshita N, Seino Y, et al. Circulating levels and bone contents of bone ψ-carboxyglutamic acid-containing protein are decreased in streptozotocin-induced diabetes: possible marker of diabetic osteopenia. Diabetes 1988;37:702–6.

  19. 19.

    Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ. Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet 1984;I:1091–3.

  20. 20.

    Wettenhall REH, Schwarz PL, Bornstein J. Actions of insulin and growth hormone on collagen and chrondroitin sulfate synthesis in bone organ cultures. Diabetes 1969;18:280–4.

  21. 21.

    Terada M, Inaba M, Yano Y, Hasuma T, Nishizawa Y, Shuzo S. Growth inhibitory effect of high glucose concentrations on osteoblast-like MG-63 cells. Bone, in press.

  22. 22.

    Yoshida O, Inaba M, Terada M, Shioi A, Nishizawa Y, Otani S, Morii H. Impaired response of human osteosarcoma (MG-63) cells to human parathyroid hormone induced by sustained exposure to high glucose. Miner Electrolyte Metab 1995; 21:201–5.

  23. 23.

    Inaba M, Terada M, Koyama H, Yoshida O, Ishimura E, Kawagishi T, et al. Influence of high glucose on 1,25-dihydroxyvitamin D3-induced effect on human osteoblast-like MG-63 cells. J Bone Miner Res 1995;10:1050–6.

  24. 24.

    Shioi A, Teitelbaum SL, Ross FP, Welgus HG, Suzuki H, Ohara J, Lacey DL. Interleukin 4 inhibits murine osteoclast formation in vitro. J Cell Biochem 1991;47:272–7.

  25. 25.

    Berry GT. The role of polyols in the pathophysiology of hypergalactosemia. Eur J Pediatr 1995;154(Suppl 2):S53–64.

  26. 26.

    Robinson WG Jr, Nagata M, Laver N, Hohman TC, Kinoshita JH. Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor. Exp Eye Res 1990;50:355–66.

  27. 27.

    Kern TS, Engerman RL. Galactose-induced retinal microangiopathy in rats. Invest Ophthalmol Vis Sci 1995;36:490–6.

  28. 28.

    Cameron NE, Cotter MA, Rebertson S, Cox D. Muscle and nerve dysfunction in rats with experimental galactosemia. J Exp Physiol 1992;77:89–108.

  29. 29.

    Mizisin AP, Powell HC, Schwann cell injury is attenuated by aldose reductase inhibition in galactose intoxication. J Neuropathol Exp Neurol 1993;52:78–86.

  30. 30.

    Han Z-H, Palnitkar S, Sudhaker Rao D, Nelson D, Parfitt AM. Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: implications for mechanisms of bone loss. J Bone Miner Res 1997;12:498–508.

  31. 31.

    Krakauer JC, McKenna MJ, Buderer NF, Rao DS, Whitehouse FW, Parfitt AM. Bone loss and bone turnover in diabetes. Diabetes 1995;44:775–82.

  32. 32.

    Frost HM. Some ABCs of skeletal pathophysiology. 5. Microdamage physiology. Calcif Tissue Int 1991;49:229–31.

  33. 33.

    McKenna MJ, Kleerekoper M, Ellis BI, Rao DS, Parfitt AM, Frame B. Atypical insufficiency fractures confused with loser zones of osteomalacia. Bone 1987;8:71–8.

  34. 34.

    Verhaeghe J, Suiker AMH, Einhorn TA, Geusens P, Visser WJ, Herck EV, et al. Brittle bones in spontaneously diabetic female rats cannot be predicted by bone mineral measurements: studies in diabetic and ovariectomized rats. J Bone Miner Res 1994;9:1657–67.

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Correspondence to M. Inaba MD.

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Inaba, M., Nishizawa, Y., Shioi, A. et al. Importance of sustained high glucose condition in the development of diabetic osteopenia: Possible involvement of the polyol pathway. Osteoporos Int 7, 209–212 (1997). https://doi.org/10.1007/BF03194374

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Keywords

  • High Glucose
  • NIDDM Patient
  • Epalrestat
  • Murine Bone Marrow Cell
  • High Mannitol