Dexamethasone bovine pharmacokinetics

  • Ph. Gaignage
  • G. Lognay
  • D. Bosson
  • D. Vertongen
  • Ph. Dreze
  • M. Marlier
  • M. Severin
Article

Summary

Dexamethasone phosphate (DXM-PHO) is an ester which is quickly hydrolysed by the bovine and the dexamethasone (DXM) plasma half-life was 5.16 h. It has been demonstrated that 54h after DXM-PHO injection, DXM concentrations were lower than 0.1 mg/ml.

Tritiated dexamethasone was also administered twice to an another young bull for metabolite investigation. The elapsed time required to recover, in plasma, half of the radioactivity injected was 8.8h. Radioactivity recovery in the urine reached 36.4% and 22.6% for the first and the second injections respectively.

Keywords

Dexamethasone half-life bovine plasma urine 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Ph. Gaignage
    • 1
  • G. Lognay
    • 1
  • D. Bosson
    • 2
  • D. Vertongen
    • 2
  • Ph. Dreze
    • 3
  • M. Marlier
    • 1
  • M. Severin
    • 1
  1. 1.Department of General and Organic ChemistryFaculty of Agricultural SciencesGemblouxBelgium
  2. 2.Department of Medical Chemistry and Internal Medicine, Saint-Pierre HospitalFree University of BrusselsBelgium
  3. 3.Department of PhysicsFaculty of Agricultural SciencesGemblouxBelgium

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