Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Comparative blood level of Dihydroergotoxine (DHET) after administration of two oral forms (solution & tablet): A Preliminary Study

  • 9 Accesses

  • 4 Citations

Summary

In this preliminary study, using a radioimmunoassay, we demonstrate that the DHET blood levels observed after admini; tration of an oral solution to human subjects, were different from those obtained after administration of a slow-release table After administration of the oral solution, the DHET blood levels rose quickly, reached a peak between 1 and 2 hours and the decrease rapidly. On the contrary, after ingestion of a slow-release tablet of DHET, the plasma levels took 6 hours to reach the maximum due to the slow release of the drug from this dosage form. In both cases, the areas under the curves were very simih but the relative bioavailability of DHET in these two forms is very different if one considers the two components of availabilit; extent and rate.

The equality of the areas under the curves indicated that the extent of DHET available was the same, but time-course of tl plasma levels showed that the rate at which DHET became available was significantly slower. Therefore the tablet form ha given the desired «slow-release» availability for which it was designed.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Adling, W.H., Nüesch, E. (1977): Comparative pharmacokinetic investigations with tritium-labelled ergot alkaloids after oral and intravenous administration in man, Br. J. Clin. Pharmacol., 15, 106–112.

  2. 2.

    Loddo, P., Spano, P.F., Trabucchi, M. (1976): Urinary elimination of dihydro-ergotoxine after oral administration and intravenous infusion, Boll. Chim. Farm., 115, 570–574.

  3. 3.

    Pasotti, V., Fleischmann, L. (1975): Assorbimento «in vitro» di diidroergotossina metansulfonato (DHET) in forma semplice e ritardata, Boll. Chim. Farm. 114, 259–269.

  4. 4.

    Kleimola, T.T., (1978): Quantitative determination of ergot alkaloids in biological fluids by radioimmunoassay, Br. J. Clin. Pharmacol., 254–260.

  5. 5.

    Rosenthaler, J., Munzer, H. (1976): Dihydroergotamine: production of antibodies and radioimmunoassay, 32, (2), 234–236.

Download references

Author information

Correspondence to Jean -Marc Aiache.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Aiache, J.-., Briot, M., Couquelet, J. et al. Comparative blood level of Dihydroergotoxine (DHET) after administration of two oral forms (solution & tablet): A Preliminary Study. European Journal of Drug Metabolism and Pharmacokinetics 6, 221–224 (1981). https://doi.org/10.1007/BF03189491

Download citation

Key words

  • DHET
  • relative bioavailability
  • solution
  • slow-release tablet
  • drug release