In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine

  • A. Frigerio
  • P. Negrini
  • L. Cappellini
  • D. Rotilio
  • A. De Pascale
  • E. Rossi
Original Papers
Received:

Summary

Dibenzo [c,f]-[1,2] diazepine is a new compound with a tricyclic structure and a double bond between two nitrogen atoms in positions 1 and 2 of the molecule.

Itsin vitro metabolism has been studied, incubating the compound with rat liver microsomes. Two metabolites have been identified : dibenzo [c,f]-[1,2]diazepine-l-N-oxide and a monohydroxyderivative in the aromatic ring.

Key-words

In vitro metabolism dibenzo[c,f]-[1,2]diazepine mass spectrometry 
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Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • A. Frigerio
    • 1
  • P. Negrini
    • 1
  • L. Cappellini
    • 1
  • D. Rotilio
    • 1
  • A. De Pascale
    • 1
  • E. Rossi
    • 1
  1. 1.Istituto di Ricerche Farmacologiche ‘Mario Negri’MilanItaly

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