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In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine

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Dibenzo [c,f]-[1,2] diazepine is a new compound with a tricyclic structure and a double bond between two nitrogen atoms in positions 1 and 2 of the molecule.

Itsin vitro metabolism has been studied, incubating the compound with rat liver microsomes. Two metabolites have been identified : dibenzo [c,f]-[1,2]diazepine-l-N-oxide and a monohydroxyderivative in the aromatic ring.

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Correspondence to A. Frigerio.

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Frigerio, A., Negrini, P., Cappellini, L. et al. In vitro studies on the metabolism of dibenzo[c,f]-[1,2]diazepine. European Journal of Drug Metabolism and Pharmacokinetics 4, 35–41 (1979). https://doi.org/10.1007/BF03189397

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  • In vitro metabolism
  • dibenzo[c,f]-[1,2]diazepine
  • mass spectrometry