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Effect of two graded doses of x-irradiation on the rat adrenal gland and its protection by S-phenetyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride

Abstract

In the present study the amount of protection offered by the use of S-phenetyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride to adrenal gland was investigated on albino rats against two graded doses of x-rays (1500R each). Total body x-irradiation brought about the hypertrophy and degranulation of adrenal cortical and medullary cells. The extent of hypertrophy and degranulation increased after the 2nd exposure to x-rays. Treatment with S-phenetyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride prior to each dose of irradiation precluded the radiation changes caused in the adrenal cortex and medulla of the rats.

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References

  1. Bacq Z M 1965Chemical protection against ionizing radiation (Springfeld: Charless C Thomas).

  2. Bacq Z M, Cuypers Y, Evrand E and Soctens R 1955 Action de la cysteamine sur la resistance du rat a la depression barometrique;C. R. Soc. Biol. Paris 149 2014–2017

  3. Berliner D L, Stevens W and Berliner M L 1962 The effect of ionizing radiation on the biosynthesis and biotransformation of corticosteroids. In:The effects of ionizing radiation on the reproductive system. (Oxford: Pergamon Press).

  4. Dougherty T F and White A 1946 Pituitary-adrenal cortical control of lymphocyte structure and function as revealed by experimental irradiation.Endocrinology 39 370–385

  5. French A B, Migeon C J, Samuels L T and Bowers J Z 1955 Effects of whole-body x-irradiation on 17-hydroxy corticosteroid levels, leucocytes and volume of packed red cells in the rhesus monkey;Am. J. Physiol. 182 469–476

  6. Hasan S S, Chaturvedi P K and Pandey S N 1983 Effect of two graded doses of whole-body x-irradiation and radioprotection by the use of S-phenetyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride;Nucl. Med. 22 237–245

  7. Hasan S S, Sarkar F H, Sharma T R, Prasad G C, Pant G C and Udupa K N 1977 Response of adrenal gland to whole-body60Co irradiation;Indian J. Exp. Biol. 15 513–516

  8. Nabors C J Jr 1962 A model system for the study of radiation effects on adrenal steroidogenesis;Radiat. Res. 16 557

  9. Nabors C J Jr, Hinckley J S and Fowkes K L 1974 Steroid 11-β-hydroxy dehydrogenase activity in beagles bearing 241;Radiat. Res. 59 212 (Abstr)

  10. Sarkar F H, Hasan S S, Pandey S N, Prasad G C and Udupa K N 1978 Effect of a chemical radioprotector administered before irradiation on thyroid, testes, and pituitary;Indian J. Med. Res. 67 616–621

  11. Stevens W, Berliner D L and Dougherty T F 1963 The effect of x-irradiation on the conjugation of steroids;Radiat. Res. 20 510–518

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Correspondence to P K Chaturvedi.

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Chaturvedi, P.K., Hasan, S.S. Effect of two graded doses of x-irradiation on the rat adrenal gland and its protection by S-phenetyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride. Proc Ani Sci 94, 523–526 (1985). https://doi.org/10.1007/BF03186362

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Keywords

  • X-rays
  • S-phenetyl formamidino 4(N-ethyl isothioamide) morpholine dihydrochloride
  • adrenal gland