Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Effect of prolactin on tissue cholesterol levels of male albino rats

  • 8 Accesses


Prolactin modulated tissue cholesterol distribution of male albino rats. Testis and epididymis had elevated cholesterol levels which was correlated to increased androgenesis. Both prostate and seminal vesicles had depleted levels, might be due to elevated seminal plasma secretion. Since heart and dorsal aorta recorded significant accumulation of cholesterol in response to prolactin administration, involvement of prolactin in cardiovascular disorders in rats was envisaged.

This is a preview of subscription content, log in to check access.


  1. Bartke A 1966 Influence of prolactin on the male fertility cf Dwarf mice;J. Endocrinol 35 419–420

  2. Bartke A 1967 Prolactin deficiency in genetically sterile dwarf mice;Mem. Soc. Endocrinol. 15 193–199

  3. Bartke A and Lloyd C W 1970 Influence of prolactin and pituitary isografts on spermatogenesis in dwarf mice and hypophysectomized rats;J. Endocrinol. 46 321–329

  4. Brecher P I and Chobanian A V 1974 Cholesterol estersynthesis in normal and atherosclerotic aortas of rabbits and rhesus monkeys;Ore. Res. 35 692–701

  5. Dorfman R I and Shipley R A 1956Androgens (New York: John Wiley)

  6. Dungan E Richard and Porter W John 1977Hormonal regulation of cholesterol synthesis in Biochemical actions of Hormones (New York: Academic Press) Vol. IV

  7. Hafiez A A, Bartke A and Lloyd C W 1972a The role cf prolactin in the regulation of testis function. The synergistic effects of prolactin and luteinizing hormone on the interperation of (1−14c) acetate into testosterone and cholesterol by the testis from hypophysectomized ratsin vitro;J. Endocrinol. 53 223–230

  8. Hafiez A A, Lloyd C W and Bartke A 1972b The role of prolactin in the regulation of testis function. The effects of prolactin and luteinizing hormone and androstenedione in hypophysectomized rats;J. Endocrinol 52 327–332

  9. Hall P F 1963 The effect of ICSH on the biosynthesis of testicular cholesterol from acetate-1−14c;Biochemistry 2 201–205

  10. Hall P F, Nishizawa E E and Eik-Nes K B 1963 Biosynthesis of testosterone by rabbit testis homogertate V. Slices;Proc. Soc. Exp. Biol. Med. 114 791–794

  11. HarperA Harold 1975Review of physiological chemistry 16th Ed. (Japan: Lange Medical Publication and Maruzen Company Ltd.)

  12. Mann T 1964The biochemistry of semen and the male reproductive tract (New York: Methuen and John Wiley)

  13. Natelson 1971Techniques of clinical chemistry, 3rd ed. (Illinois: Charles C. Thomas Publishers)

  14. Prasad MRN and Rajalakshmi M 1976 Comparative physiology of mammalian epididymis;Gen. Comp. Endocrinol. 28 530–537

  15. Ramachandra Rao M, Gajalakshmi V, Murthy M S R, Indira K and Govindappa S 1978 Effect of prolactin administration on phospholipid content in selected reproductive and non-reproductive tissues of albino rats;Indian J. Exp. Biol. 16 254–255

  16. Scott W W 1945J. Urol. 53 712–715 as cited inThe biochemistry of semen and of the male reproductive tract (ed,) T Mann (New York: Methuen and John Wiley)

  17. Thomass W A, Florentin R A, Nam S C, Kim D N, Jones R M and Lee K T 1968 Preproliferative phase of atherosclerosis in swine fed cholesterol;Arch. Pathol. 86 621–643

Download references

Author information

Correspondence to M Ramachandra Rao.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rao, M.R., Reddy, G.V., Govindappa, S. et al. Effect of prolactin on tissue cholesterol levels of male albino rats. Proc Ani Sci 90, 529–532 (1981). https://doi.org/10.1007/BF03186031

Download citation


  • Prolactin
  • cholesterol
  • testis
  • androgenesis
  • heart
  • cardiovascular disorders