Abstract
An NIH3T3 cell line which overexpresses temperature-sensitive p53Val135 was constructed by introduction of p53Val135 gene. It exhibited rapidly characteristic morphological and biochemical alterations related to replicative senescence when being cultured in 32 °C. We suggested that the overexpression of p53 activated probably the onset of senescence in NIH3T3 cells, which induced a rapid cellular senescence.
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Hu, J., Lei, Y., Hong, X. et al. Rapid senescence induced by overexpression of p53 in NIH3T3 cells. Chin. Sci. Bull. 46, 653–656 (2001). https://doi.org/10.1007/BF03182827
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DOI: https://doi.org/10.1007/BF03182827