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Nuclear oxidation in the flavone series

Part IX. Oxidation of related chalkones
  • S. Rajagopalan
  • T. R. Seshadri
Article

Summary

It is shown that the nuclear oxidation of hydroxy-chalkones can be successfully effected thereby introducing a fresh hydroxyl in the 5-position which corresponds to the 6-position in flavanones and flavones. 2-Hydroxy-4-methoxy-chalkone and 2-hydroxy-4∶6-dimethoxy-chalkone have thus been oxidised to the 2∶5-dihydroxy compounds. In the first case the product is shown to be 2∶5-dihydroxy-4-methoxy-chalkone by complete methylation and identification of the derivative as 2∶4∶5-trimethoxy-chalkone. In the second case it is proved to be 2∶5-dihydroxy-4∶6-dimethoxy-chalkone by partial methylation and conversion into 5∶6∶7-trimethoxy-flavanone.

Keywords

Flavone Flavanone Aqueous Sodium Hydroxide Anhydrous Potassium Carbonate Dimethyl Sulphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Indian Academy of Sciences 1948

Authors and Affiliations

  • S. Rajagopalan
    • 1
  • T. R. Seshadri
    • 1
  1. 1.Department of ChemistryAndhra UniversityWaltair

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