Journal of Physiology and Biochemistry

, Volume 64, Issue 1, pp 61–66 | Cite as

ZAG, a lipid mobilizing adipokine, is downregulated in human obesity

  • M. P. Marrades
  • J. A. Martínez
  • M. J. Moreno-Aliaga


The main goal of this study was to compare the expression of Zinc-α2-glycoprotein (ZAG), a recently described adipokine, in obese and lean subjects. ZAG expression was determined by Real-time PCR analysis in subcutaneous abdominal adipose tissue of eighteen young men, 9 lean (BMI=23.1±0.4 kg/m2) and 9 obese (34.7±1.2 kg/m2) with a similar habitual dietary intake of fat and physical activity, which were assessed by validated methods. Our data revealed that ZAG gene was downregulated (−70%; p<0.05) in subcutaneous adipose tissue of obese compared to lean subjects. Moreover, statistically significant positive correlations between ZAG gene expression and serum adiponectin (r=0.89; p<0.01) and a negative correlation with the plasma levels of leptin (r=−0.82; p<0.05) and waist circumference (r=−0.64; p<0.05) were found in obese subjects. Our data suggest that this novel adipokine could play a role in human susceptibility to obesity related disorders and that upregulation of ZAG could be a promising therapeutic target for metabolic syndrome treatment.

Key words

Adipose tissue Diet induced obesity ZAG 

La expresión génica de ZAG, una adipoquina lipolítica, está reprimida en sujetos obesos


El objetivo del presente estudio fue la comparación de los niveles de expresión génica de ZAG (Zinc-α2-gylcoprotein), una adipoquina lipolítica, entre sujetos obesos y normoponderales. Los niveles de expresión del gen ZAG se determinaron mediante PCR en tiempo real en tejido adiposo subcutáneo de 18 adultos jóvenes, 9 de ellos normoponderales (IMC=23,1±0,4 kg/m2) y 9 obesos (IMC=34,7±1,2 kg/m2), que presentaban una ingesta calórica similar y una actividad física moderada. Los niveles de expresión de ZAG estaban reprimidos (−70%; p<0,05) en el tejido adiposo subcutáneo de los sujetos obesos en comparación con los normoponderales. Además, los niveles de ZAG se correlacionaron positivamente con los niveles plasmáticos de adiponectina (r=0,89; p<0,01) y negativamente con los niveles de leptina (r=−0,82; p<0,05) y el perímetro de la cintura (r=∮0,64; p<0,05) en los sujetos obesos. Estos datos sugieren que la menor expresión de esta nueva adipoquina podría explicar la mayor acumulación de triglicéridos en los adipocitos de los sujetos obesos, y contribuir a la susceptibilidad a desarrollar desórdenes relacionados con la obesidad.

Palabras clave

Tejido adiposo Obesidad inducida por la dieta ZAG 


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Copyright information

© Universidad de Navarra 2008

Authors and Affiliations

  • M. P. Marrades
    • 1
  • J. A. Martínez
    • 1
  • M. J. Moreno-Aliaga
    • 1
  1. 1.Department of Nutrition and Food Science, Physiology and ToxicologyUniversity of NavarraPamplonaSpain

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