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Coma secondary to aciclovir neurotoxicity

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References

  1. Rajan GRC, Cobb JP, Reiss CK. Acyclovir induced coma in the intensive care unit.Anaesth Intensive Care 2000; 28: 305–7.

    PubMed  CAS  Google Scholar 

  2. Laskin OL, Longstreth JA, Whelton A et al. Effect of renal failure on the pharmacokinetics of acyclovir.Am J Med 1982; 73(1A): 176–81.

    Google Scholar 

  3. Wood AJJ. Acyclovir: a decade later.New Engl J Med 1992; 327(11): 782–9.

    Article  Google Scholar 

  4. Daugirdas JT, Ing T. In Handbook of Dialysis. Little Brown and Co. 1993.

  5. Whitley RJ, Blum MR, Barton N, De Miranda P. Pharmacokinetics of acyclovir in humans following intrvenous administration: a model for the development of parenteral antivirals.Am J Med 1982; 73(1A): 165–71.

    Article  PubMed  CAS  Google Scholar 

  6. De Knegt RJ, van der Pil H, van Es LA. Acyclovir associaed encephalopathy-lack of relationship between acyclovir levels and symptoms.Nephrol Dial Transplant 1995; 10: 1775–7.

    PubMed  Google Scholar 

  7. Haefeli WE, Schoenenberger RA, Weiss P, Ritz RR. Acyclovir-induced neurotoxicity: concentration-side effectrelationship in acyclovir overdose.Am J Med 1993; 94(2): 212–5.

    Article  PubMed  CAS  Google Scholar 

  8. Jackson SHD. Pharmcodynamics in the elderly.J R Soc Med 1994; 1994; 87(S23): 5–7.

    PubMed  Google Scholar 

  9. Bataille P, Devos P, Noel JL, Dautrevaux C, Lokiec F. Psychiatric side effects with acyclovir (letter).Lancet 1985; 2: 724.

    Article  PubMed  CAS  Google Scholar 

  10. Bean B, Aeppli D. Adverse effects of high dose intravenous acyclovir in ambulatory patients with acute herpeszoster.J Infect Dis 1985; 151: 362–5.

    PubMed  CAS  Google Scholar 

  11. Wood AJJ. Post herpetic neuralgia-pathogenesis, treatment and prevention.New Engl J Med 1996; 335(1): 32–42.

    Article  Google Scholar 

  12. de Greef H. Famciclovir, a new oral anti-herpes drug; results of the first controlled clinical study demonstrating its efficacy and safety in the treatment of uncomplicated herpes zoster in immunocompetent patients,Int J Antimicrob Agents 1995; 4: 241–6.

    Google Scholar 

  13. Ernst ME, Franey RJ. Acyclovir- and ganciclovir-induced neurotoxicity.Ann Pharmacother 1998; 32: 111–3.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Anaesthesia and Intensive Care Medicine, Mater Misercordiae Hospital, Dublin, Ireland

    J. Loughrey & B. Marsh

  2. Departments of Nephrology and Hypertension, Mater Misercordiae Hospital, Dublin, Ireland

    P. Coleman & J. Donohue

Authors
  1. J. Loughrey
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  2. P. Coleman
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  3. J. Donohue
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  4. B. Marsh
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Corresponding author

Correspondence to J. Loughrey.

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Loughrey, J., Coleman, P., Donohue, J. et al. Coma secondary to aciclovir neurotoxicity. Ir J Med Sci 170, 69–70 (2001). https://doi.org/10.1007/BF03167726

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  • DOI: https://doi.org/10.1007/BF03167726

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