Global dynamics of B cells and anti-idiotipic B cells and its application to autoimmunity

  • Toru SasakiEmail author
  • Tsuyoshi Kajiwara


Global behavior of B models is discussed. When the source term for new B cells equals zero, the system has a conservation quantity. It implies the structurally unstability. It suggests that lack of the source of new B cells may unstabilize the immune system. When the B model incorporates autoimmunity, it loses symmetry. The asymmetry suggests the transition from a tolerant state to autoimmune state is more likely than the inverse transition. Effect of dose of antigen is also considered.

Key words

B model global dynamics conservation quantity autoimmunity 


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Copyright information

© JJIAM Publishing Committee 2007

Authors and Affiliations

  1. 1.Okayama UniversityJapan

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