Aluminum-induced acute cholinergic neurotoxicity in rat
- 35 Downloads
In the present study the acute effect of intravenous aluminum chloride (1 mg/kg) on choline acetyltransferase (ChAT) and acetyl-cholinesterase (AChE) activities of rats was investigated. Aluminum was found to cross the blood-brain barrier (BBB) as indicated by the detection of aluminum in the cerebrospinal fluid (CSF) 30 min after femoral vein injection. Two hours following aluminum injection, ChAT activity in the basal forebrain and hippocampus was significantly reduced by 30% and 22%, respectively, whereas no change was observed in the caudate nuclei. On the other hand, AChE activity was significantly increased by 45% in the caudate nuclei, whereas little change was observed in other brain areas. This report demonstrates that rapid transport of Al across the BBB, and the acute nature of Al neurotoxicity in rats.
Index EntriesAluminum transport blood-brain barrier cerebrospinal fluid aluminum acute aluminum effect cholinergic neurotoxicity neurofibrillary degeneration choline acetyltransferase acetylcholinesterase
Unable to display preview. Download preview PDF.
- Candy J. M., Oakley A. E., Atack J., Perry R. H., Perry E. K., and Edwardson J. A. (1984) New observations on the nature of senile plaque cores, inDevelopments in Neuroscience, Vol. 17: Regulation of Transmitter Function: Basic and Clinical Aspects (Vizi E. S. and Magyar K., eds.), pp. 301–304, Elsevier, New York.Google Scholar
- Crapper McLachlan D. R. and De Boni U. (1980) Aluminum in human brain disease-an overview.Neurotoxicology 1, 3–16.Google Scholar
- Crapper McLachlan D. R., Lukiw W. J., and Kruck T. P. A. (1989) New evidence for an active role of aluminum in Alzheimer’s disease.Can. J. Neuro. Sci. 16, 490–497.Google Scholar
- Davis P. and Wolozin B. L. (1987) Recent advances in the neurochemistry of Alzheimer’s disease.J. Clin. Psychiatry 48, 23–30.Google Scholar
- DeBoni U., Otvos A., Scott J. W., and Crapper McLachlan D. R. (1976) Neurofibrillary degeneration induced by systemic aluminum.Acta Neuropath. (Berl.)35, 285–294.Google Scholar
- McDermitt J. R., Smith A. L., Iqbal K., and Wisniewski H. M. (1979) Brain aluminum in aging and Alzheimer’s disease.Neurology 29, 809–814.Google Scholar
- Perl D. P. and Good P. F. (1990) Aluminum environment and Alzheimer’s disease: Active role or passive bystander?Neurobiol. Aging 11, 83.Google Scholar