Netherlands Heart Journal

, Volume 18, Issue 4, pp 197–201 | Cite as

The effect of insulin on the heart

Part 1: Effects on metabolism and function
  • L. J. Klein
  • F. C. Visser
Review article
Insulin Heart Metabolism Heart Failure Ventribular Function 


Positive inotropic effects of insulin were described early after the isolation of insulin from the pancreas but data on the effect of insulin on the heart are conflicting. Systemic insulin administration results in a reduction in circulating free fatty acids and an improvement in myocardial glucose uptake, which causes an efficiency improvement in the myocardial cell. There is strong evidence that insulin administration results in functional improvement in dysfunctional myocardium. (Neth Heart J 2010;18:197-201.)


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Copyright information

© Bohn Stafleu van Loghum 2010

Authors and Affiliations

  1. 1.Department of CardiologyVU Medical CentreAmsterdamthe Netherlands
  2. 2.

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