Tijdschrift voor kindergeneeskunde

, Volume 72, Issue 2, pp 59–64 | Cite as

Respiratoir syncytieel virus bronchiolitis: rol van genetische polymorfismen

  • J. L. L. Kimpen
  • G.M. van Bleek
  • L.J. Bont
  • T. Kimman
  • B. Hoebee
Artikelen
  • 58 Downloads

Samenvatting

De variabiliteit in ernst van ziekte na infectie met het respiratoir syncytieel virus (rsv), alsook het risico op recurrent piepen in de jaren volgend op de infectieuze episode, wordt beïnvloed door een aantal epidemiologische en demografische factoren (leeftijd, maand van geboorte, roken in het gezin), en de klinische voorgeschiedenis van de patiënt (prematuriteit, chronisch longlijden, congenitaal hartlijden). Daarnaast bepalen polymorfismen in genen coderend voor belangrijke eiwitten van het immuunsysteem wellicht de uitkomst van de infectie bij een bepaald individu. Een aantal van deze genetische polymorfismen is inmiddels beschreven en geassocieerd met ernstige ziekte na infectie met rsv. Helaas is de functionele betekenis van de meeste polymorfismen nog onduidelijk, zodat de bruikbaarheid als prognostische factoren in de kliniek vooralsnog gering is.

Summary

The variability in disease severity after infection with respiratory syncytial virus (rsv), and the risk for recurrent wheezing after the initial episode, is influenced by a number of epidemiologic and demographic factors including the month of birth, smoking in the household, and a medical history of prematurity, chronic lung disease or congenital heart defects. Next to these factors, outcome of infection is probably influenced by genetic polymorphisms in genes encoding for proteins playing a role in the immune response. Some of these polymorphisms have been studied in detail and correlated with severity of rsv-induced disease. Unfortunately functional correlates of these polymorphisms are still lacking. Thus far the clinical relevance of these polymorphisms as prognostic factors is unclear.

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Copyright information

© Bohn Stafleu van Loghum 2004

Authors and Affiliations

  • J. L. L. Kimpen
    • 1
  • G.M. van Bleek
  • L.J. Bont
  • T. Kimman
  • B. Hoebee
  1. 1.

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