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Andrologie

, Volume 1, Issue 2, pp 56–58 | Cite as

Les proteines majeures de la secretion prostatique

  • Jean Y. Dubé
Physiologie

Resume

La sécrétion prostatique humaine ne contient que quelques protéines majeures parmi lesquelles on retrouve l’albumine, la phosphatase acide, l’antigène spécifique à la prostate (PSA), la protéine de sécrétion de 94 acides aminés (PSP94), la Zn-α2-glycoprotéine et l’α1-glycoprotéine. Le rôle de la plupart de ces protéines n’est pas entièrement connu. On sait toutefois que le PSA contribue à l’hydrolyse des protéines du coagulum formé lors de l’éjaculation. Les rôles probables des autres constituants incluent l’altération des propriétés de surface du spermatozoïde et le contrôle des réponses inflammatoires dans les tractus urogénitaux de l’homme et de la femme.

Mots clefs

fluide prostatique ejaculat plasma séminal vésicules séminales 

Major prostatic secretory proteins

Abstract

Human prostatic secretion contains only a few major proteins among which one finds albumin, acid phosphatase, prostate specific antigen (PSA), prostatic secretory protein of 94 amino acids (PSP94), Zn-α2-glycoprotein and α1-acid glycoprotein. The roles of most of these proteins are not entirely known. However, PSA has been shown to contribute to the hydrolysis of the seminal coagulum proteins. Probable roles for the other components include modifications of the properties of spermatozoa surface and control of inflammatory responses in male and female urogenital tracts.

Keys words

prostatic fluid ejaculate seminal plasma seminal vesicles 

References

  1. 1.
    -Araki T, Gejyo F, Takagaki K, Haupt H, Schwick HC, Burgi W, Marti T, Schaller J, Rickli E, Brossmer R, Atkinson PH, Putnam FW, Schmid K. Complete amino acid sequence of human plasma Zn-α2-glycoprotein and its homology to histo compatibility antigens. Proceed. Natl Acad. Sci. (USA), 1988, 85:679–683.CrossRefGoogle Scholar
  2. 2.
    -Chantananukul W, Panyim S. In vitro specific phosphorylation of the human seminal proteins. Andrologia, 1982, 14:447–453.PubMedCrossRefGoogle Scholar
  3. 3.
    -Dubé JY, Frenette G, Paquin R, Chapdelaine P, Tremblay J, Tremblay RR, Lazure C, Seidah N, Chrétien M. Isolation from human seminal plasma of an abundant 16 kDa protein originating from the prostate. Its identification with a 94-residue peptide described as ß-inhibin. J. Andrology, 1987, 8:182–189.Google Scholar
  4. 4.
    -Dubé JY, Paradis G, Têtu B, Tremblay RR. Synthesis of α1-acid glycoprotein by the human prostate. Prostate, 1989, 15:251–258.PubMedCrossRefGoogle Scholar
  5. 5.
    -Eliasson R. Biochemical analysis of semen. Int. J. Androl., 1982, Suppl 5:109–119.CrossRefGoogle Scholar
  6. 6.
    -Frenette G, Tremblay RR, Dubé JY. Zinc binding to major human seminal coagulum proteins. Arch. Androl., 1989, 23:155–163.PubMedCrossRefGoogle Scholar
  7. 7.
    -Frenette G, Dubé JY, Lazure C, Paradis G, Chrétien M, Tremblay RR. The major 40 kDa glycoprotein in human prostatic fluid is identifical to Zn-α2-glycoprotein. Prostate, 1987, 11:257–270.PubMedCrossRefGoogle Scholar
  8. 8.
    -Haagensen DE, Mazoujian G. Biochemistry and immunochemistry of fluid proteins in the breast in gross cystic disease. In “Diseases of the Breast” 3rd edition, Cann C. ed., W. B. Saunders Co, 1986:474–500.Google Scholar
  9. 9.
    -Lilja H, Abrahamsson PA, Lundwall A. Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa. J. Biol. Chem., 1989, 264:1894–1900.PubMedGoogle Scholar
  10. 10.
    -Lilja H, Laurell CB. Liquefaction of coagulated human semen. Scand. J. Clin. Lab. Invest., 1984, 44:447–452.PubMedCrossRefGoogle Scholar
  11. 11.
    -Lilja H, Oldbring J, Rannevik G, Laurell CB. Seminal vesicle secreted proteins and their reactions during gelation and liquefaction of human semen. J. Clin. Invest., 1987, 80:281–285.PubMedCrossRefGoogle Scholar
  12. 12.
    -Lin MF, Clinton GM. Human protastic acid phosphatase has phosphotyrosyl protein phosphatase activity. Biochem. J., 1986, 235:351–357.PubMedGoogle Scholar
  13. 13.
    -Lizana JA, Eneroth P. Proteins in seminal plasma and cervicovaginal secretions. In “Proteins in body fluids, amino acids and tumor markers: diagnostic and clinical aspects”, Alan R. Liss Inc., New York, 1983:271–274.Google Scholar
  14. 14.
    -Polak B, Daunter B. Seminal plasma biochemistry. IV: Enzymes involved in the liquefaction of human seminal plasma. Int. J. Androl., 1989, 12:187–194.PubMedCrossRefGoogle Scholar
  15. 15.
    -Putnam FW. The plasma proteins. Structure, function, and genetic control. Volume IV, 2nd edition, Academic Press, Orlando, 1984, 420 pp.Google Scholar
  16. 16.
    -Serrano JA, Wasserkrug HL, Serrano AA, Paul BD, Seligman AM. The histochemical demonstration of human prostatic acid phosphatase with phosphorylcholine. Invest. Urol., 1977, 15:123–136.PubMedGoogle Scholar
  17. 17.
    -Sharief FS, Lee H, Leudermann MM, Lundwall A, Deaven LL, Lee CL, Li SSL. Human prostatic acid phosphatase: cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. Biochem. Biophys. Res. Commun., 1989, 160:79–86.PubMedCrossRefGoogle Scholar
  18. 18.
    -Ulvsback M, Lindstrom C, Weiber H, Abrahamsson PA, Lilja H, Lundwall A. Molecular cloning of a small prostate protein known as β microsemino-protein, PSP94 or β inhibin and demonstration of transcripts in non genital tissues. Biochem. Biophys. Res. Commun., 1989, 164:1310–1315.PubMedCrossRefGoogle Scholar
  19. 19.
    -Wang MC, Valenzuela LA, Murphy GP, Chu TM. Purification of a human prostate specific antigen. Invest. Urol., 1979, 17:159–163.PubMedGoogle Scholar
  20. 20.
    -Watt KWK, Lee PJ, M’Timkulu T, Chan WP, Loor R. Human prostate specific antigen: structural and functional similarity with serine proteases. Proceed. Natl Acad. Sci (USA), 1986, 83:3166–3170.CrossRefGoogle Scholar

Copyright information

© Société d’Andrologie de Langue Française 1991

Authors and Affiliations

  • Jean Y. Dubé
    • 1
    • 2
  1. 1.Laboratoire de Biorégulation hormonaleCentre Hospitalier de l’Université LavalSte-FoyCanada
  2. 2.Dépt. de médecineUniversité LavalSte FoyCanada

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