Botulinum toxin therapy for cervical dystonia
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Cervical dystonia (CD) is the most common form of focal dystonia treated with botulinum toxin (BoNT) injections. BoNT has been shown in numerous clinical trials to correct the abnormal posture and movement and to markedly reduce pain associated with CD. In addition, BoNT has favorably modified the natural history of the disease by preventing contractures and other complications of CD, such as secondary degenerative changes of the cervical spine and associated radiculopathy. In a long-term follow-up of patients treated for up to 20 years, the duration of response appears to be sustained and the risk of immunoresistance due to blocking antibodies is relatively small. This review provides and update on the treatment of CD with BoNT type A (BOTOX®, Dysport®, Xeomin®) and BoNT type B (Myobloc™, NeuroBloc®).
KeywordsDystonia Cervical Botulinum toxin
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- Comella CL, J Jankovic, S Daggett, J Mordaunt and MF Brin (2004) Interim results of an observational study of neutralizing antibody formation with the current preparation of botulinum toxin type A treatment for cervical dystonia.Neurology 62 (Suppl. 5), A511.Google Scholar
- Consky ES and AE Lang (1994) Clinical assessments of patients with cervical dystonia, In:Therapy with Botulinum Toxin (Jankovic J and M Hallett, Eds.) (Marcel Dekker: New York, NY),pp 211–237.Google Scholar
- Diamond A, J Shahed, S Azher, K Dat-Vuong, R Simpson and J Jankovic (2005) Globus pallidus deep brain stimulation in dystonia.Mov. Disord. 2005 Dec 9; [Epub ahead of print].Google Scholar
- Jankovic J, J Tsui and C Bergeron (2005a) Prevalence of cervical dystonia and spasmodic torticollis in the United States.Mov. Disord. 20 (Suppl. 10) S22a.Google Scholar
- Jankovic J, CB Hunter and the BOS Study Group (2005b) Botulinum toxin type B observational study.Ann. Neurol. 58 (Suppl. 9) S54.Google Scholar
- Truong D, DD Duane, J Jankovic, C Singer, LC Seeberger, CL Comella, MF Lew, RL Rodnitzky, FO Danisi, JP Sutton, PD Charles, RA Hauser and GL Sheean (2005) Efficacy and safety of botulinum type A toxin (Dysport®) in cervical dystonia: results of the first US randomized, double-blind, placebo-controlled study.Mov. Disord. 20, 783–791.PubMedCrossRefGoogle Scholar
- Vidailhet M, L Vercueil, JL Houeto, P Krystkowiak, AL Benabid, P Cornu, C Lagrange, S Tezenas du Montcel, D Dormont, S Grand, S Blond, O Detante, B Pillon, C Ardouin, Y Agid, A Destee, P Pollak and the French Stimulation du Pallidum Interne dans la Dystonie (SPIDY) Study Group (2005) Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia.N. Engl. J. Med. 352, 459–467.PubMedCrossRefGoogle Scholar