Neurotoxicity Research

, Volume 12, Issue 1, pp 43–60

Treatment consideration and manifest complexity in comorbid neuropsychiatric disorders

  • Tomas Palomo
  • Richard M. Kostrzewa
  • Richard J. Beninger
  • Trevor Archer


Psychiatric disorders may co-occur in the same individual. These include, for example, substance abuse or obsessive-compulsive disorder with schizophrenia, and movement disorders or epilepsy with affective dysfunctional states. Medications may produce iatrogenic effects, for example cognitive impairments that co-occur with the residual symptoms of the primary disorder being treated. The observation of comorbid disorders in some cases may reflect diagnostic overlap. Impulsivity, impulsiveness or impulsive behaviour is implicated in a range of diagnostic conditions including substance abuse, affective disorder and obsessive-compulsive disorder. These observations suggest a need to re-evaluate established diagnostic criteria and disorder definitions, focusing instead on symptoms and symptom-profiles.


Treatment Symptoms Obsessive-compulsive Psychosis Comorbidity Schizophrenia Impulsivity Affective Epilepsy Substance abuse Neuropsychiatry 


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Copyright information

© Springer 2007

Authors and Affiliations

  • Tomas Palomo
    • 1
  • Richard M. Kostrzewa
    • 2
  • Richard J. Beninger
    • 3
  • Trevor Archer
    • 4
    • 5
  1. 1.Psychiatry Service, “12 de Octubre”University HospitalMadridSpain
  2. 2.Department of Pharmacology, Quillen College of MedicineEast Tennessee State UniversityJohnson CityUSA
  3. 3.Departments of Psychology and PsychiatryQueen’s UniversityKingstonCanada
  4. 4.Department of PsychologyUniversity of GöteborgGöteborg
  5. 5.HBVUniversity of KalmarKalmarSweden

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