Neurotoxicity Research

, Volume 8, Issue 1–2, pp 167–186 | Cite as

Experimental and potential future therapeutic approaches for HIV-1 associated dementia targeting receptors for chemokines, glutamate and erythropoietin

Part IV Neuroprotective Agents

Abstract

Severe and debilitating neurological problems that include behavioral abnormalities, motor dysfunction and frank dementia can occur after infection with the human immunodeficiency virus-1 (HIV-1). Infected peripheral immune-competent cells, in particular macrophages, infiltrate the central nervous system (CNS) and provoke a neuropathological response involving all cell types in the brain. HIV-1 infection results in activation of chemokine receptors, inflammatory mediators, extracellular matrix-degrading enzymes and glutamate receptor-mediated excitotoxicity, all of which can trigger numerous downstream signaling pathways that result in disruption of neuronal and glial function. Despite many major improvements in the control of viral infection in the periphery, a truly effective therapy for HIV-1 associated dementia is currently not available. This review will discuss experimental and potentially future therapeutic strategies based on recently uncovered pathologic mechanisms contributing to neuronal damage induced by HIV-1.

Keywords

NeuroAIDS Neurodegeneration Therapy HIV-1 Pharmacology Inflammation Central nervous system 

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References

  1. Adamson DC, B Wildemann, M Sasaki, JD Glass, JC McArthur, VI Christov, TM Dawson and VL Dawson (1996) Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41.Science 274, 1917–1921.PubMedGoogle Scholar
  2. Adle-Biassette H, Y Levy, M Colombel, F Poron, S Natchev, C Keohane and F Gray (1995) Neuronal apoptosis in HIV infection in adults.Neuropathol. Appl. Neurobiol. 21, 218–227.PubMedGoogle Scholar
  3. Adle-Biassette H, F Chretien, L Wingertsmann, C Hery, T Ereau, F Scaravilli, M Tardieu and F Gray (1999) Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage.Neuropathol. Appl. Neurobiol. 25, 123–133.PubMedGoogle Scholar
  4. Agace WW, A Amara, AI Roberts, JL Pablos, S Thelen, M Uguccioni, XY Li, J Marsal, F Arenzana-Seisdedos, T Delaunay, EC Ebert, B Moser and CM Parker (2000) Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation.Curr. Biol. 10, 325–328.PubMedGoogle Scholar
  5. Aizenman E, AK Stout, KA Hartnett, KE Dineley, B McLaughlin and IJ Reynolds (2000) Induction of neuronal apoptosis by thiol oxidation: putative role of intracellular Zinc release.J. Neurochem. 75, 1878–1888.PubMedGoogle Scholar
  6. Alkhatib G, C Combadiere, CC Broder, Y Feng, PE Kennedy, PM Murphy and EA Berger (1996) CC CKR5: a RANTES, MIP- 1alpha, MIP-1beta receptor as a fusion cofactor for macrophagetropic HIV-1.Science 272, 1955–1958.PubMedGoogle Scholar
  7. Anderson ER, HE Gendelman and H Xiong (2004) Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis.J. Neurosci. 24, 7194–7198.PubMedGoogle Scholar
  8. Ankarcrona M, JM Dypbukt, E Bonfoco, B Zhivotovsk, S Orrenius, SA Lipton, and P Nicotera (1995) Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial integrity.Neuron 15, 961–973.PubMedGoogle Scholar
  9. Arundine M and M Tymianski (2004) Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury.Cell. Mol. Life Sci. 61, 6578–668.Google Scholar
  10. Asensio VC and IL Campbell (1999) Chemokines in the CNS: plurifunctional mediators in diverse states.Trends Neurosci. 22, 504–512.PubMedGoogle Scholar
  11. Bazan JF, KB Bacon, G Hardiman, W Wang, K Soo, D Rossi, DR Greaves, A Zlotnik and TJ Schall (1997) A new class of membrane-bound chemokine with a CX3C motif.Nature 385, 640–644.PubMedGoogle Scholar
  12. Beckman JS, TW Beckman, J Chen, PA Marshall and BA Freeman (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.Proc. Natl. Acad. Sci. USA 87, 1620–1624.PubMedGoogle Scholar
  13. Bezzi P, G Carmignoto, L Pasti, S Vesce, D Rossi, BL Rizzini, T Pozzan and A Volterra (1998) Prostaglandins stimulate calciumdependent glutamate release in astrocytes.Nature 391, 281–285.PubMedGoogle Scholar
  14. Bezzi P, M Domercq, L Brambilla, R Galli, D Schols, E De Clercq, A Vescovi, G Bagetta, G Kollias, J Meldolesi and A Volterra (2001) CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.Nat. Neurosci. 4, 702–710.PubMedGoogle Scholar
  15. Bigge CF (1999) Ionotropic glutamate receptors.Curr. Opin. Chem. Biol. 3, 441–447.PubMedGoogle Scholar
  16. Bleul CC, M Farzan, H Choe, C Parolin, I Clark-Lewis, J Sodroski and TA Springer (1996) The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.Nature 382, 829–833.PubMedGoogle Scholar
  17. Bonfoco E, D Krainc, M Ankarcrona, P Nicotera and SA Lipton (1995) Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.Proc. Natl. Acad. Sci. USA 92, 7162–7166.PubMedGoogle Scholar
  18. Bormann J (1989) Memantine is a potent blocker of N-methyl-Daspartate (NMDA) receptor channels.Eur. J. Pharmacol. 166, 591–592.PubMedGoogle Scholar
  19. Bossy-Wetzel E, MV Talantova, WD Lee, MN Schölzke, A Harrop, E Mathews, T Götz, J Han, MH Ellisman, GA Perkins and SA Lipton (2004) Cross-talk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels.Neuron 41, 351–365.PubMedGoogle Scholar
  20. Brack-Werner R and JE Bell (1999) Replication of HIV-1 in human astrocytes.Science Online: NeuroAids (www sciencemag org /NAIDS) 2, 1–7.Google Scholar
  21. Brauner-Osborne H, J Egebjerg, EO Nielsen, U Madsen and P Krogsgaard-Larsen (2000) Ligands for glutamate receptors: design and therapeutic prospects.J. Med. Chem. 43, 2609–2645.PubMedGoogle Scholar
  22. Brenneman DE, GL Westbrook, SP Fitzgerald, DL Ennist, KL Elkins, MR Ruff and CB Pert (1988) Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide.Nature 335, 639–642.PubMedGoogle Scholar
  23. Brew BJ, J Corbeil, L Pemberton, L Evans, K Saito, R Penny, DA Cooper and MP Heyes (1995) Quinolinic acid production is related to macrophage tropic isolates of HIV-1.J. Neurovirol. 1, 369–374.PubMedGoogle Scholar
  24. Bruno V, A Copani, G Besong, G Scoto and F Nicoletti (2000) Neuroprotective activity of chemokines against N-methyl-Daspartate or beta-amyloid-induced toxicity in culture.Eur. J. Pharmacol. 399, 117–121.PubMedGoogle Scholar
  25. Budd SL, L Tenneti, T Lishnak and SA Lipton (2000) Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons.Proc. Natl. Acad. Sci. USA 97, 6161–6166.PubMedGoogle Scholar
  26. Budka H (1991) Neuropathology of human immunodeficiency virus infection.Brain Pathol. 1, 163–175.PubMedGoogle Scholar
  27. Budka H, G Costanzi, S Cristina, A Lechi, C Parravicini, R Trabattoni and L Vago (1987) Brain pathology induced by infection with the human immunodeficiency virus (HIV). A histological, immunocytochemical, and electron microscopical study of 100 autopsy cases.Acta Neuropathol. (Berl.) 75, 185–198.Google Scholar
  28. Celik M, N Gokmen, S Erbayraktar, M Akhisaroglu, S Konakc, C Ulukus, S Genc, K Genc, E Sagiroglu, A Cerami and M Brines (2002) Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.Proc. Natl. Acad. Sci. USA 99, 2258–2263.PubMedGoogle Scholar
  29. Chapman GA, K Moores, D Harrison, CA Campbell, BR Stewart and PJ Strijbos (2000) Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage.J. Neurosci. (Online)20, RC87.PubMedGoogle Scholar
  30. Chen HS and SA Lipton (1997) Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism.J. Physiol. 499 (Pt. 1), 27–46.PubMedGoogle Scholar
  31. Chen HS, JW Pellegrini, SK Aggarwal, SZ Lei, S Warach, FE Jensen and SA Lipton (1992) Open-channel block of N-methyl D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity.J. Neurosci. 12, 4427–4436.PubMedGoogle Scholar
  32. Chen HS, YF Wang, PV Rayudu, P Edgecomb, JC Neill, MM Segal, SA Lipton and FE Jensen (1998) Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation.Neuroscience 86, 1121–1132.PubMedGoogle Scholar
  33. Chen W, J Sulcove, I Frank, S Jaffer, H Ozdener and DL Kolson (2002) Development of a human neuronal cell model for human immunodeficiency virus (HIV)-infected macrophage-induced neurotoxicity: apoptosis induced by HIV type 1 primary isolates and evidence for involvement of the Bcl-2/Bcl-xL-sensitive intrinsic apoptosis pathway.J. Virol. 76, 9407–9419.PubMedGoogle Scholar
  34. Choe H, M Farzan, Y Sun, N Sullivan, B Rollins, PD Ponath, L Wu, CR Mackay, G LaRosa, W Newman, N Gerard, C Gerard and J Sodroski (1996) The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.Cell 85, 1135–1148.PubMedGoogle Scholar
  35. Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system.Neuron 1, 623–634.PubMedGoogle Scholar
  36. Choi DW, JY Koh and S Peters (1988a) Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists.J. Neurosci. 8, 185–196.PubMedGoogle Scholar
  37. Choi DW, M Yokoyama and J Koh (1988b) Zinc neurotoxicity in cortical cell culture.Neuroscience 24, 67–79.PubMedGoogle Scholar
  38. Choi YB, L Tenneti, DA Le, J Ortiz, G Bai, HS Chen and SA Lipton (2000) Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation.Nat. Neurosci. 3, 15–21.PubMedGoogle Scholar
  39. Choi YB, HS Chen and SA Lipton (2001) Three pairs of cysteine residues mediate both redox and Zn2+ modulation of the NMDA receptor.J. Neurosci. 21, 392–400.PubMedGoogle Scholar
  40. Chung KK, B Thomas, X Li, O Pletnikova, JC Troncoso, L Marsh, VL Dawson and TM Dawson (2004) S-Nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function.Science 304, 1328–1331.PubMedGoogle Scholar
  41. Clifford DB (1999) Central neurologic complications of HIV infection.Curr. Infect. Dis. Rep. 1, 187–191.PubMedGoogle Scholar
  42. Clifford DB (2000) Human immunodeficiency virus-associated dementia.Arch. Neurol. 57, 321–324.PubMedGoogle Scholar
  43. Cocchi F, AL Devico, A Garzino-Demo, SK Arya, RC Gallo and P Lusso (1995) Identification of RANTES, MIP-1 alpha, and MIP- 1 beta as the major HIV- suppressive factors produced by CD8+ T cells.Science 270, 1811–1815.PubMedGoogle Scholar
  44. Conant K, A Garzino-Demo, A Nath, JC McArthur, W Halliday, C Power, RC Gallo and EO Major (1998) Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.Proc. Natl. Acad. Sci. USA 95, 3117–3121.PubMedGoogle Scholar
  45. Cunningham PH, DG Smith, C Satchell, DA Cooper and B Brew (2000) Evidence for independent development of resistance to HIV-1 reverse transcriptase inhibitors in the cerebrospinal fluid.AIDS 14, 1949–1954.PubMedGoogle Scholar
  46. D’hooge R, F Franck, L Mucke and PP De Deyn (1999) Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120.Eur. J. Neurosci. 11, 4398–4402.PubMedGoogle Scholar
  47. Das S, YF Sasaki, T Rothe, LS Premkumar, M Takasu, JE Crandall, P Dikkes, DA Conner, PV Rayudu, W Cheung, HS Chen, SA Lipton and N Nakanishi (1998) Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3a.Nature 393, 377–381.PubMedGoogle Scholar
  48. Dawson VL, TM Dawson, ED London, DS Bredt and SH Snyder (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.Proc. Natl. Acad. Sci. USA 88, 6368–6371.PubMedGoogle Scholar
  49. Dawson VL, TM Dawson, DA Bartley, GR Uhl and SH Snyder (1993) Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures.J. Neurosci. 13, 2651–2661.PubMedGoogle Scholar
  50. De Clercq E (2004) HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches.Int. J. Biochem. Cell. Biol. 36, 1800–1822.PubMedGoogle Scholar
  51. Digicaylioglu M and SA Lipton (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades.Nature 412, 641–647.PubMedGoogle Scholar
  52. Digicaylioglu M, G Garden, S Timberlake, L Fletcher and SA Lipton (2004a) Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I.Proc. Natl. Acad. Sci. USA 101, 9855–9860.PubMedGoogle Scholar
  53. Digicaylioglu M, M Kaul, L Fletcher, R Dowen and SA Lipton (2004b) Erythropoietin protects cerebrocortical neurons from HIV-1/gp120-induced damage.Neuroreport 15, 761–763.PubMedGoogle Scholar
  54. Dimmeler S, J Haendeler, M Nehls and AM Zeiher (1997) Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases.J. Exp. Med. 185, 601–607.PubMedGoogle Scholar
  55. Doble A (1999) The role of excitotoxicity in neurodegenerative disease: implications for therapy.Pharmacol. Ther. 81, 163–221.PubMedGoogle Scholar
  56. Doranz BJ, J Rucker, Y Yi, RJ Smyth, M Samson, SC Peiper, M Parmentier, RG Collman and RW Doms (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR5, CKR3, and CKR2b as fusion cofactors.Cell 85, 1149–1158.PubMedGoogle Scholar
  57. Dore GJ, JF Hoy, SA Mallal, Y Li, AM Mijch, MA French, DA Cooper and JM Kaldor (1997) Trends in incidence of AIDS illnesses in Australia from 1983 to 1994: the Australian AIDS cohort.J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16, 39–43.PubMedGoogle Scholar
  58. Dore GJ, PK Correll, Y Li, JM Kaldor, DA Cooper and BJ Brew (1999) Changes to AIDS dementia complex in the era of highly active antiretroviral therapy.AIDS 13, 1249–1253.PubMedGoogle Scholar
  59. Dragic T, V Litwin, GP Allaway, SR Martin, Y Huang, KA Nagashima, C Cayanan, PJ Maddon, RA Koup, JP Moore and WA Paxton (1996) HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.Nature 381, 667–673.Google Scholar
  60. Dreyer EB and SA Lipton (1995) The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.Eur. J. Neurosci. 7, 2502–2507.PubMedGoogle Scholar
  61. Dreyer EB, PK Kaiser, JT Offermannand SA Lipton (1990) HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists.Science 248, 364–367.PubMedGoogle Scholar
  62. Ellis RJ, R Deutsch, RK Heaton, TD Marcotte, JA McCutchan, JA Nelson, I Abramson, LJ Thal, JH Atkinson, MR Wallace and I Grant (1997) Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center Group.Arch. Neurol. 54, 416–424.PubMedGoogle Scholar
  63. Enting RH, RM Hoetelmans, JM Lange, DM Burger, JH Beijnen and P Portegies (1998) Antiretroviral drugs and the central nervous system.AIDS 12, 1941–1955.PubMedGoogle Scholar
  64. Erdo SL and M Schafer (1991) Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate.Eur. J. Pharmacol. 198, 215–217.PubMedGoogle Scholar
  65. Everall IP, RK Heaton, TD Marcotte, RJ Ellis, JA McCutchan, JH Atkinson, I Grant, M Mallory and E Masliah (1999) Cortical synaptic density is reduced in mild to moderate human immunodeficiency virus neurocognitive disorder. HNRC group. HIV Neurobehavioral Research Center.Brain Pathol. 9, 209–217.PubMedGoogle Scholar
  66. Ferrando S, W van Gorp, M McElhiney, K Goggin, M Sewell and J Rabkin (1998) Highly active antiretroviral treatment in HIV infection: benefits for neuropsychological function.AIDS 12, F65-F70.PubMedGoogle Scholar
  67. Fiala M, DJ Looney, M Stins, DD Way, L Zhang, X Gan, F Chiappelli, ES Schweitzer, P Shapshak, M Weinand, MC Graves, M Witte and KS Kim (1997) TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier.Mol. Med. 3, 553–564.PubMedGoogle Scholar
  68. Fischer-Smith T, S Croul, AE Sverstiuk, C Capini, D L’Heureux, EG Regulier, MW Richardson, S Amini, S Morgello, K Khalili and J Rappaport (2001) CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection.J. Neurovirol. 7, 528–541.PubMedGoogle Scholar
  69. Fontana G, L Valenti and M Raiteri (1997) gp120 can revert antagonism at the glycine site of NMDA receptors mediating GABA release from cultured hippocampal neurons.J. Neurosci. Res. 49, 732–738.PubMedGoogle Scholar
  70. Fox L, M Alford, C Achim, M Mallory and E Masliah (1997) Neurodegeneration of somatostatin-immunoreactive neurons in HIV encephalitis.J. Neuropathol. Exp. Neurol. 56, 360–368.PubMedGoogle Scholar
  71. Gabuzda DH, DD Ho, SM de la Monte, MS Hirsch, TR Rota and RA Sobel (1986) Immunohistochemical identification of HTLVIII antigen in brains of patients with AIDS.Ann. Neurol. 20, 289–295.PubMedGoogle Scholar
  72. Galasso JM, JK Harrison and FS Silverstein (1998) Excitotoxic brain injury stimulates expression of the chemokine receptor CCR5 in neonatal rats.Am. J. Pathol. 153, 1631–1640.PubMedGoogle Scholar
  73. Garden GA, SL Budd, E Tsai, L Hanson, M Kaul, DM D’Emilia, RM Friedlander, J Yuan, E Masliah and SA Lipton (2002) Caspase cascades in human immunodeficiency virus-associated neurodegeneration.J. Neurosci. 22, 4015–4024.PubMedGoogle Scholar
  74. Garden GA, W Guo, S Jayadev, C Tun, S Balcaitis, J Choi, TJ Montine, T Moller and RS Morrison (2004) HIV associated neurodegeneration requires p53 in neurons and microglia.FASEB J. 18, 1141–1143.PubMedGoogle Scholar
  75. Gartner S (2000) HIV infection and dementia.Science 287, 602–604.PubMedGoogle Scholar
  76. Gelbard HA, HJ James, LR Sharer, SW Perry, Y Saito, AM Kazee, BM Blumberg and LG Epstein (1995) Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy.Neuropathol. Appl. Neurobiol. 21, 208–217.PubMedGoogle Scholar
  77. Gendelman HE, I Grant, SA Lipton, I Everall and S Swindells (2005)The Neurology of AIDS (Oxford University Press: London), 1184 pp.Google Scholar
  78. Genis P, M Jett, EW Bernton, T Boyle, HA Gelbard, K Dzenko, RW Keane, L Resnick, Y Mizrachi, DJ Volskyet al. (1992) Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease.J. Exp. Med. 176, 1703–1718.PubMedGoogle Scholar
  79. Ghatan S, S Larner, Y Kinoshita, M Hetman, L Patel, Z Xia, RJ Youle and RS Morrison (2000) p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons.J. Cell. Biol. 150, 335–347.PubMedGoogle Scholar
  80. Giulian D, K Vacaand CA Noonan (1990) Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1.Science 250, 1593–1596.PubMedGoogle Scholar
  81. Giulian D, E Wendt, K Vaca and CA Noonan (1993) The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes.Proc. Natl. Acad. Sci. USA 90, 2769–2773.PubMedGoogle Scholar
  82. Giulian D, J Yu, X Li, D Tom, J Li, E Wendt, SN Lin, R Schwarcz and C Noonan (1996) Study of receptor-mediated neurotoxins released by HIV-1 infected mononuclear phagocytes found in human brain.J. Neurosci. 16, 3139–3153.PubMedGoogle Scholar
  83. Glass JD, H Fedor, SL Wesselingh and JC McArthur (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia.Ann. Neurol. 38, 755–762.PubMedGoogle Scholar
  84. Gleichmann M, C Gillen, M Czardybon, F Bosse, R Greiner-Petter, J Auer and HW Muller (2000) Cloning and characterization of SDF-1gamma, a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system.Eur. J. Neurosci. 12, 1857–1866.PubMedGoogle Scholar
  85. Gonzalez-Zulueta M, AB Feldman, LJ Klesse, RG Kalb, JF Dillman, LF Parada, TM Dawson and VL Dawson (2000) Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning.Proc. Natl. Acad. Sci. USA 97, 436–441.PubMedGoogle Scholar
  86. Gu Z, M Kaul, B Yan, SJ Kridel, J Cui, A Strongin, JW Smith, RC Liddington and SA Lipton (2002) S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death.Science 297, 1186–1190.PubMedGoogle Scholar
  87. He J, Y Chen, M Farzan, H Choe, A Ohagen, S Gartner, J Busciglio, X Yang, W Hofmann, W Newman, CR Mackay, J Sodroski and D Gabuzda (1997) CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia.Nature 385, 645–649.PubMedGoogle Scholar
  88. Hesselgesser J, D Taub, P Baskar, M Greenberg, J Hoxie, DL Kolson and R Horuk (1998) Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4.Curr. Biol. 8, 595–598.PubMedGoogle Scholar
  89. Heyes MP, BJ Brew, A Martin, RW Price, AM Salazar, JJ Sidtis, JA Yergey, MM Mouradian, AE Sadler, J Keilp, D Rubinow and SP Markey (1991) Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status.Ann. Neurol. 29, 202–209.PubMedGoogle Scholar
  90. Jain KK (2000) Evaluation of memantine for neuroprotection in dementia.Expert Opin. Investig. Drugs 9, 1397–1406.PubMedGoogle Scholar
  91. Jiang ZG, C Piggee, MP Heyes, C Murphy, B Quearry, M Bauer, J Zheng, HE Gendelman and SP Markey (2001) Glutamate is a mediator of neurotoxicity in secretions of activated HIV-1- infected macrophages.J. Neuroimmunol. 117, 97–107.PubMedGoogle Scholar
  92. Johnston JB, Y Jiang, G van Marle, MB Mayne, W Ni, J Holden, JC McArthur and C Power (2000) Lentivirus infection in the brain induces matrix metalloproteinase expression: role of envelope diversity.J. Virol. 74, 7211–7220.PubMedGoogle Scholar
  93. Kaul M (2002) Chemokines and their receptors in HIV-associated dementia.J. Neurovirol. 8 (suppl. 1), 41–42.Google Scholar
  94. Kaul M and SA Lipton (1999) Chemokines and activated macrophages in gp120-induced neuronal apoptosis.Proc. Natl. Acad. Sci. USA 96, 8212–8216.PubMedGoogle Scholar
  95. Kaul M and SA Lipton (2001) Knock out of HIV-1 coreceptors attenuates neuronal apoptosis induced by HIV envelope glycoprotein gp120. Soc. Neurosci. 27, 678.8 (Abstr.).Google Scholar
  96. Kaul M, GA Garden and SA Lipton (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia.Nature 410, 988–994.PubMedGoogle Scholar
  97. Kaul M, J Zheng, S Okamoto, HE Gendelman and SA Lipton (2005) HIV-1 infection and AIDS: consequences for the central nervous system.Cell Death Differ. 12 (Suppl. 1), 878–892.PubMedGoogle Scholar
  98. Keilhoff G and G Wolf (1992) Memantine prevents quinolinic acid-induced hippocampal damage.Eur. J. Pharmacol. 219, 1Google Scholar
  99. Kikuchi M, L Tenneti and SA Lipton (2000) Role of p38 mitogenactivated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells.J. Neurosci. 20, 5037–5044.PubMedGoogle Scholar
  100. Kim WK, YB Choi, PV Rayudu, P Das, W Asaad, DR Arnelle, JS Stamler and SA Lipton (1999) Attenuation of NMDA receptor activity and neurotoxicity by nitroxyl anion, NO-.Neuron 24, 461–469.PubMedGoogle Scholar
  101. Koenig S, HE Gendelman, JM Orenstein, MC Dal Canto, GH Pezeshkpour, M Yungbluth, F Janotta, A Aksamit, MA Martin and AS Fauci (1986) Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy.Science 233, 1089–1093.PubMedGoogle Scholar
  102. Kohr G, S Eckardt, H Luddens, H Monyer and PH Seeburg (1994) NMDA receptor channels: subunit-specific potentiation by reducing agents.Neuron 12, 1031–1040.PubMedGoogle Scholar
  103. Krathwohl MD and JL Kaiser (2004a) Chemokines promote quiescence and survival of human neural progenitor cells.Stem Cells 22, 109–118.PubMedGoogle Scholar
  104. Krathwohl MD and JL Kaiser (2004b) HIV-1 promotes quiescence in human neural progenitor cells.J. Infect. Dis. 190, 216–226.PubMedGoogle Scholar
  105. LangfordD, VJ Sanders, M Mallory, M Kaul and E Masliah (2002) Expression of stromal cell-derived factor 1alpha protein in HIV encephalitis.J. Neuroimmunol. 127, 115–126.PubMedGoogle Scholar
  106. Lannuzel A, PM Lledo, HO Lamghitnia, JD Vincent and M Tardieu (1995) HIV-1 envelope proteins gp120 and gp160 potentiate NMDA [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.Eur. J. Neurosci. 7, 2285–2293.PubMedGoogle Scholar
  107. Lapidot T and I Petit (2002) Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells.Exp. Hematol. 30, 973–981.PubMedGoogle Scholar
  108. Le D, S Das, YF Wang, T Yoshizawa, YF Sasaki, M Takasu, A Nemes, M Mendelsohn, P Dikkes, SA Lipton and N Nakanishi (1997) Enhanced neuronal death from focal ischemia in AMPAreceptor transgenic mice.Brain Res. Mol. Brain Res. 52, 235–241.PubMedGoogle Scholar
  109. Le DA and SA Lipton (2001) Potential and current use of N-methyl- D-aspartate (NMDA) receptor antagonists in diseases of aging.Drugs Aging 18, 717–724.PubMedGoogle Scholar
  110. Lees KR (1997) Cerestat and other NMDA antagonists in ischemic stroke.Neurology 49, S66-S69.PubMedGoogle Scholar
  111. Lei SZ, ZH Pan, SK Aggarwal, HS Chen, J Hartman, NJ Sucher and SA Lipton (1992) Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex.Neuron 8, 1087–1099.PubMedGoogle Scholar
  112. Letendre SL, ER Lanier and JA McCutchan (1999) Cerebrospinal fluid beta chemokine concentrations in neurocognitively impaired individuals infected with human immunodeficiency virus type 1.J. Infect. Dis. 180, 310–319.PubMedGoogle Scholar
  113. Lipton SA (1991a) Calcium channel antagonists and human immunodeficiency virus coat protein-mediated neuronal injury.Ann. Neurol. 30, 110–114.PubMedGoogle Scholar
  114. Lipton SA (1991b) Calcium channel antagonists in the prevention of neurotoxicity.Adv. Pharmacol. 22, 271–297.PubMedGoogle Scholar
  115. Lipton SA (1992a) Memantine prevents HIV coat protein-induced neuronal injuryin vitro.Neurology 42, 1403–1405.PubMedGoogle Scholar
  116. Lipton SA (1992b) Models of neuronal injury in AIDS: another role for the NMDA receptor?Trends Neurosci. 15, 75–79.PubMedGoogle Scholar
  117. Lipton SA (1992c) Requirement for macrophages in neuronal injury induced by HIV envelope protein gp120.Neuroreport 3, 913–915.PubMedGoogle Scholar
  118. Lipton SA (1993) Prospects for clinically tolerated NMDA antagonists: open-channel blockers and alternative redox states of nitric oxide.Trends Neurosci. 16, 527–532.PubMedGoogle Scholar
  119. Lipton SA (1994a) HIV coat protein gp120 induces soluble neurotoxins in culture medium.Neurosci. Res. Commun. 15, 31–37.Google Scholar
  120. Lipton SA (1994b) HIV displays its coat of arms.Nature 367, 113–114 [Erratum 367, 320].PubMedGoogle Scholar
  121. Lipton SA (1997a) Neuropathogenesis of acquired immunodeficiency syndrome dementia.Curr. Opin. Neurol. 10, 247–253.PubMedGoogle Scholar
  122. Lipton SA (1997b) Treating AIDS dementia [letter; comment].Science 276, 1629–1630.PubMedGoogle Scholar
  123. Lipton SA (1998) Neuronal injury associated with HIV-1: approaches to treatment.Annu. Rev. Pharmacol. Toxicol. 38, 159–177.PubMedGoogle Scholar
  124. Lipton SA (2004a) Erythropoietin for neurologic protection and diabetic neuropathy.N. Engl. J. Med. 350, 2516–2517.PubMedGoogle Scholar
  125. Lipton SA (2004b) Concepts: turning down but not off — Neuroprotection requires a paradigm shift in drug development.Nature 428, 473.PubMedGoogle Scholar
  126. Lipton SA (2004c) Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults.NeuroRx 1, 101–110.PubMedGoogle Scholar
  127. Lipton SA (2005) The molecular basis of memantine action in Alzheimer’s disease and other neurologic disorders: low affinity, uncompetitive antagonism.Curr. Alzheim. Res. 2(2), 155–165.Google Scholar
  128. Lipton SA and H-SV Chen (2004) Paradigm shift in neuroprotective drug development: clinically tolerated NMDA receptor inhibition by memantine.Cell Death Diff. 11, 18–20.Google Scholar
  129. Lipton SA and HE Gendelman (1995) Seminars in Medicine of the Beth Israel Hospital, Boston. Dementia associated with the acquired immunodeficiency syndrome.N. Engl. J. Med. 332, 934–940.PubMedGoogle Scholar
  130. Lipton SA and FE Jensen (1992) Memantine, a clinically-tolerated NMDA open-channel blocker, prevents HIV coat proteininduced neuronal injuryin vitro andin vivo. Soc. Neurosci.18, 757 (Abstr.).Google Scholar
  131. Lipton SA and K Kieburtz (1998) Development of adjunctive therapies for the neurologic manifestations of AIDS: dementia and painful neuropathy, In:The Neurology of AIDS (Gendelman HE, SA Lipton, LG Epstein and S Swindells, Eds.) (Chapman and Hall: New York), pp 377–381.Google Scholar
  132. Lipton SA and P Nicotera (1998) Calcium, free radicals and excitotoxins in neuronal apoptosis.Cell Calcium 23, 165–171.PubMedGoogle Scholar
  133. Lipton SA and PA Rosenberg (1994) Excitatory amino acids as a final common pathway for neurologic disorders.N. Engl. J. Med. 330, 613–622.PubMedGoogle Scholar
  134. Lipton SA and JS Stamler (1994) Actions of redox-related congeners of nitric oxide at the NMDA receptor.Neuropharmacology 33, 1229–1233.PubMedGoogle Scholar
  135. Lipton SA, Y-B Choi, ZH Pan, SZ Lei, H-SV Chen, NJ Sucher, J Loscalzo, DJ Singel and JS Stamler (1993) A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds.Nature 364, 626–632.PubMedGoogle Scholar
  136. Lipton SA, Y-B Choi, T Takahashi, D Zhang, W Li, A Godzik and LA Bankston (2002) Cysteine regulation of protein function - as exemplified by NMDA-receptor modulation.Trends Neurosci. 25, 474–480.PubMedGoogle Scholar
  137. Lipton SA, NJ Sucher, PK Kaiser and EB Dreyer (1991) Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity.Neuron 7, 111–118.PubMedGoogle Scholar
  138. Lipton SA and YF Wang (1996) NO-related species can protect from focal cerebral ischemia/reperfusion, In:Pharmacology of Cerebral Ischemia (Krieglstein J, Ed.) (Medpharm Scientific Publ.: Stuttgart), pp 183–191.Google Scholar
  139. Lipton SA, T Nakamura, D Yao, Z-Q Shi, T Uehara and Z Gu (2005) Comment on S-nitrosylation of parkin regulates ubiquitination and compromises parkin’s protective function.Science 308 (5730), 1870; author reply 1870.PubMedGoogle Scholar
  140. Liu R, WA Paxton, S Choe, D Ceradini, SR Martin, R Horuk, ME MacDonald, H Stuhlmann, RA Koup and NR Landau (1996) Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.Cell 86, 367–377.PubMedGoogle Scholar
  141. Liu Y, M Jones, CM Hingtgen, G Bu, N Laribee, RE Tanzi, RD Moir, A Nath and JJ He (2000) Uptake of HIV-1 Tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.Nat. Med. 6, 1380–1387.PubMedGoogle Scholar
  142. Lo TM, CJ Fallert, TM Piser and SA Thayer (1992) HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons.Brain Res. 594, 189–196.PubMedGoogle Scholar
  143. Locati M and PM Murphy (1999) Chemokines and chemokine receptors: biology and clinical relevance in inflammation and AIDS.Annu. Rev. Med. 50, 425–440.PubMedGoogle Scholar
  144. Lucas DR and JP Newhouse (1957) The toxic effect of sodium L-glutamate on the inner layers of the retina.AMA Arch. Ophthalmol. 58, 193–201.PubMedGoogle Scholar
  145. Ma Q, D Jones, PR Borghesani, RA Segal, T Nagasawa, T Kishimoto, RT Bronson and TA Springer (1998) Impaired Blymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.Proc. Natl. Acad. Sci. USA 95, 9448–9453.PubMedGoogle Scholar
  146. Major EO, D Rausch, C Marra and D Clifford (2000) HIV-associated dementia.Science 288, 440–442.PubMedGoogle Scholar
  147. Mannick JB, A Hausladen, L Liu, DT Hess, M Zeng, QX Miao, LS Kane, AJ Gow and JS Stamler (1999) Fas-induced caspase denitrosylation.Science 284, 651–654.PubMedGoogle Scholar
  148. Marshall DC, T Wyss-Coray and CR Abraham (1998) Induction of matrix metalloproteinase-2 in human immunodeficiency virus- 1 glycoprotein 120 transgenic mouse brains.Neurosci. Lett. 254, 97–100.PubMedGoogle Scholar
  149. Masliah E, N Ge, CL Achim, LA Hansen and CA Wiley (1992) Selective neuronal vulnerability in HIV encephalitis.J. Neuropathol. Exp. Neurol. 51, 585–593.PubMedGoogle Scholar
  150. Masliah E, RK Heaton, TD Marcotte, RJ Ellis, CA Wiley, M Mallory, CL Achim, JA McCutchan, JA Nelson, JH Atkinson and I Grant(1997) Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders. HNRC group. The HIV Neurobehavioral Research Center.Ann. Neurol. 42, 963–972.PubMedGoogle Scholar
  151. Masuda S, M Nagao, K Takahata, Y Konishi, F Gallyas Jr, T Tabira and R Sasaki (1993) Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells.J. Biol. Chem. 268, 11208–11216.PubMedGoogle Scholar
  152. McArthur JC (1987) Neurologic manifestations of AIDS.Medicine (Baltimore) 66, 407–437.Google Scholar
  153. McArthur JC, DR Hoover, H Bacellar, EN Miller, BA Cohen, JT Becker, NM Graham, JH McArthur, OA Selnes and LP Jacobson (1993) Dementia in AIDS patients: incidence and risk factors. Multicenter AIDS Cohort Study.Neurology 43, 2245–2252.PubMedGoogle Scholar
  154. McArthur JC, DR McClernon, MF Cronin, TE Nance-Sproson, AJ Saah, M St Clair and ER Lanier (1997) Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain.Ann. Neurol. 42, 689–698.PubMedGoogle Scholar
  155. McGrath KE, AD Koniski, KM Maltby, JK McGann and J Palis (1999) Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4.Dev. Biol. 213, 442–456.PubMedGoogle Scholar
  156. Melino G F Bernassola, RA Knight, MT Corasaniti, G Nistico and A Finazzi-Agro (1997) S-nitrosylation regulates apoptosis.Nature 388, 432–433.Google Scholar
  157. Melton ST, CK Kirkwood and SN Ghaemi (1997) Pharm-acotherapy of HIV dementia.Ann. Pharmacother. 31, 457–473.PubMedGoogle Scholar
  158. Mennicken F, R Maki, EB de Souza and R Quirion (1999) Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning.Trends Pharmacol. Sci. 20, 73–78.PubMedGoogle Scholar
  159. Meucci O, A Fatatis, AA Simen, TJ Bushell, PW Gray and RJ Miller (1998) Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity.Proc. Natl. Acad. Sci. USA 95, 14500–14505.PubMedGoogle Scholar
  160. Michael NL and JP Moore (1999) HIV-1 entry inhibitors: evading the issue [news] [see comments].Nat. Med. 5, 740–742.PubMedGoogle Scholar
  161. Moore RD, JC Keruly and RE Chaisson (1998) Anemia and survival in HIV infection.J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 19, 29–33.PubMedGoogle Scholar
  162. Morishita E, S Masuda, M Nagao, Y Yasuda and R Sasaki (1997) Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin preventsin vitro glutamate-induced neuronal death.Neuroscience 76, 105–116.PubMedGoogle Scholar
  163. Mukherjee PK, MA DeCoster, FZ Campbell, RJ Davis and NG Bazan (1999) Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death.J. Biol. Chem. 274, 6493–6498.PubMedGoogle Scholar
  164. Muller WE, HC Schroder, H Ushijima, J Dapper and J Bormann (1992) Gp120 of HIV-1 induces apoptosis in rat cortical cell cultures: prevention by memantine.Eur. J. Pharmacol. 226, 209–214.PubMedGoogle Scholar
  165. Navia BA, U Dafni, D Simpson, T Tucker, E Singer, JC McArthur, C Yiannoutsos, L Zaborski and SA Lipton (1998) A phase I/II trial of nimodipine for HIV-related neurologic complications.Neurology 51, 221–228.PubMedGoogle Scholar
  166. Navia BA, C Yiannoutsos, R Ellis, G Schifitto, A Nath, S Shriver, L Millar and SA Lipton (2005) Memantine may prevent further cognitive decline in subjects with the AIDS Dementia Complex with detectable CSF HIV RNA.Neurology 64 (Suppl. 1), A247-A238.Google Scholar
  167. Nicotera P, M Ankarcrona, E Bonfoco, S Orrenius and SA Lipton (1997) Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress.Adv. Neurol. 72, 95–101.PubMedGoogle Scholar
  168. Nottet HS, Y Persidsky, VG Sasseville, AN Nukuna, P Bock, QH Zhai, LR Sharer, RD McComb, S Swindells, C Soderland and HE Gendelman (1996) Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain.J. Immunol. 156, 1284–1295.PubMedGoogle Scholar
  169. Oberlin E, A Amara, F Bachelerie, C Bessia, JL Virelizier, F Arenzana-Seisdedos, O Schwartz, JM Heard, I Clark-Lewis, DF Legler, M Loetscher, M Baggiolini and B Moser (1996) The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1.Nature 382, 833–835.PubMedGoogle Scholar
  170. Ohagen A, S Ghosh, J He, K Huang, Y Chen, M Yuan, R Osathanondh, S Gartner, B Shi, G Shaw and D Gabuzda (1999) Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope.J. Virol. 73, 897–906.PubMedGoogle Scholar
  171. Okamoto S, Z Li, C Ju, MN Scholzke, E Mathews, J Cui, GS Salvesen, E Bossy-Wetzel and SA Lipton (2002) Dominantinterfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.Proc. Natl. Acad. Sci. USA 99, 3974–3979.PubMedGoogle Scholar
  172. Olney JW (1969) Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate.Science 164, 719–721.PubMedGoogle Scholar
  173. Olney JW and LG Sharpe (1969) Brain lesions in an infant rhesus monkey treated with monsodium glutamate.Science 166, 386–388.PubMedGoogle Scholar
  174. Orgogozo J-M, A-S Rigaud, A Stöffler, H-J Möbius and F Forette (2002) Efficacy and safety of memantine in patients with mild to moderate vascular dementia - a randomized, placebo-controlled trial (MMM 300).Stroke 33, 1834–1839.PubMedGoogle Scholar
  175. Osborne NN and G Quack (1992) Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-Daspartate-induced destruction of retinal neurones.Neurochem. Int. 21, 329–336.PubMedGoogle Scholar
  176. Parsons CG, W Danysz and G Quack (1999) Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist - a review of preclinical data.Neuropharmacology 38, 735–767.PubMedGoogle Scholar
  177. Paxton WA, R Liu, S Kang, L Wu, TR Gingeras, NR Landau, CR Mackay and RA Koup (1998) Reduced HIV-1 infectability of CD4+ lymphocytes from exposed-uninfected individuals: association with low expression of CCR5 and high production of beta-chemokines.Virology 244, 66–73.PubMedGoogle Scholar
  178. Pellegrini JW and SA Lipton (1993) Delayed administration of memantine prevents N-methyl-D-aspartate receptor-mediated neurotoxicity.Ann. Neurol. 33, 403–407.PubMedGoogle Scholar
  179. Petito CK and B Roberts (1995) Evidence of apoptotic cell death in HIV encephalitis.Am. J. Pathol. 146, 1121–1130.PubMedGoogle Scholar
  180. Pierson TC, RW Doms and S Pohlmann (2004) Prospects of HIV-1 entry inhibitors as novel therapeutics.Rev. Med. Virol. 14, 255–270.PubMedGoogle Scholar
  181. Piot P, M Bartos, PD Ghys, N Walker and B Schwartlander (2001) The global impact of HIV/AIDS.Nature 410, 968–973.PubMedGoogle Scholar
  182. Pittaluga A, R Pattarini, P Severi and M Raiteri (1996) Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.AIDS 10, 463–468.PubMedGoogle Scholar
  183. Power C, JC McArthur, A Nath, K Wehrly, M Mayne, J Nishio, T Langelier, RT Johnson and B Chesebro (1998) Neuronal death induced by brain-derived human immunodeficiency virus type 1 envelope genes differs between demented and nondemented AIDS patients.J. Virol. 72, 9045–9053.PubMedGoogle Scholar
  184. Power C, MJ Gilland RT Johnson (2002) Progress in clinical neurosciences: the neuropathogenesis of HIV infection: host-virus interaction and the impact of therapy.Can. J. Neurol. Sci. 29, 19–32.PubMedGoogle Scholar
  185. Reisberg B, R Doody, A Stöffler, F Schmitt, S Ferris and HF Möbius (2003) Memantine in moderate-to-severe Alzheimer’s disease.N. Engl. J. Med. 348, 1333–1341.PubMedGoogle Scholar
  186. Rottman JB, KP Ganley, K Williams, L Wu, CR Mackay and DJ Ringler (1997) Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection. Am. J. Pathol.151, 1341–1351.PubMedGoogle Scholar
  187. Sacktor N, RH Lyles, R Skolasky, C Kleeberger, OA Selnes, EN Miller, JT Becker, B Cohen and JC McArthur (2001) HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998.Neurology 56, 257–260.PubMedGoogle Scholar
  188. Sadamoto Y, K Igase, M Sakanaka, K Sato, H Otsuka, S Sakaki, S Masuda and R Sasaki (1998) Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery.Biochem. Biophys. Res. Commun. 253, 26–32.PubMedGoogle Scholar
  189. Samson M, F Libert, BJ Doranz, J Rucker, C Liesnard, CM Farber, S Saragosti, C Lapoumeroulie, J Cognaux, C Forceille, G Muyldermans, C Verhofstede, G Burtonboy, M Georges, T Imai, S Rana, Y Yi, RJ Smyth, RG Collman, RW Doms, G Vassart and M Parmentier (1996) Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR5 chemokine receptor gene.Nature 382, 722–725.PubMedGoogle Scholar
  190. Sardar AM, PH Hutson and GP Reynolds (1999) Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS.Neuroreport 10, 3513–3515.PubMedGoogle Scholar
  191. Sathi S, P Edgecomb, S Warach, K Manchester, T Donaghey, PE Stieg, FE Jensen and SA Lipton 1993 Chronic transdermal nitroglycerin (NTG) is neuroprotective in experimental rodent stroke models.Soc. Neurosci.19, 849 (Abstr.).Google Scholar
  192. Sattler R,Z Xiong, WY Lu, M Hafner, JF MacDonald and M Tymianski (1999) Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein.Science 284, 1845–1848.PubMedGoogle Scholar
  193. Savio T and G Levi (1993) Neurotoxicity of HIV coat protein gp120, NMDA receptors, and protein kinase C: a study with rat cerebellar granule cell cultures.J. Neurosci. Res. 34, 265–272.PubMedGoogle Scholar
  194. Scala E, G D’Offizi, R Rosso, O Turriziani, R Ferrara, AM Mazzone, G Antonelli, F Aiuti and R Paganelli (1997) C-C chemokines, IL- 16, and soluble antiviral factor activity are increased in cloned T cells from subjects with long-term nonprogressive HIV infection.J. Immunol. 158, 4485–4492.PubMedGoogle Scholar
  195. Schifitto G, N Sacktor, K Marder, MP McDermott, JC McArthur, K Kieburtz, S Small and LG Epstein (1999) Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium.Neurology 53, 391–396.PubMedGoogle Scholar
  196. Schulzer M, E Mak and DB Calne (1992) The antiparkinson efficacy of depreyl derives from transient improvement that is likely to be symptomatic.Ann. Neurol. 32, 795–798.PubMedGoogle Scholar
  197. Seif nel Nasr M, B Peruche, C Rossberg, HD Mennel and J Krieglstein (1990) Neuroprotective effect of memantine demonstratedin vivo andin vitro.Eur. J. Pharmacol. 185, 19–24.Google Scholar
  198. Simmons G, D Wilkinson, JD Reeves, MT Dittmar, S Beddows, J Weber, G Carnegie, U Desselberger, PW Gray, RA Weiss and PR Clapham (1996) Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry.J. Virol. 70, 8355–8360.PubMedGoogle Scholar
  199. Sinor AD and DA Greenberg (2000) Erythropoietin protects cultured cortical neurons, but not astroglia, from hypoxia and AMPA toxicity.Neurosci. Lett. 290, 213–215.PubMedGoogle Scholar
  200. Stieg PE, S Sathi, S Warach, DA Le and SA Lipton (1999) Neuroprotection by the NMDA receptor-associated open-channel blocker memantine in a photothrombotic model of cerebral focal ischemia in neonatal rat.Eur. J. Pharmacol. 375, 115–120.PubMedGoogle Scholar
  201. Stumm RK, J Rummel, V Junker, C Culmsee, M Pfeiffer, J Krieglstein, V Hollt and S Schulz (2002) A dual role for the SDF- 1/CXCR4 chemokine receptor system in adult brain: isoformselective regulation of SDF-1 expression modulates CXCR4- dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia.J. Neurosci. 22, 5865–5878.PubMedGoogle Scholar
  202. Sullivan JM, SF Traynelis, HS Chen, W Escobar, SF Heinemann and SA Lipton (1994) Identification of two cysteine residues that are required for redox modulation of the NMDA subtype of glutamate receptor.Neuron 13, 929–936.PubMedGoogle Scholar
  203. Susman E (2001) Memantine improves function and cognition i advanced Alzheimer’s.Inpharma Weekly 1292, 5.Google Scholar
  204. Tachibana K,S Hirota, H Iizasa, H Yoshida, K Kawabata, Y Kataoka, Y Kitamura, K Matsushima, N Yoshida, S Nishikawa, T Kishimoto and T Nagasawa (1998) The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.Nature 393, 591–594.PubMedGoogle Scholar
  205. Tariot PN, MR Farlow, GT Grossberg, SM Graham, S McDonald and I Gergel (2004) Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial.JAMA 291, 317–324.PubMedGoogle Scholar
  206. Tenneti L, DM D’Emilia and SA Lipton (1997) Suppression of neuronal apoptosis by S-nitrosylation of caspases.Neurosci. Lett. 236, 139–142.PubMedGoogle Scholar
  207. Tenneti L, DM D’Emilia, CM Troy and SA Lipton (1998) Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons.J. Neurochem. 71, 946–959.PubMedGoogle Scholar
  208. Toggas SM, E Masliah, EM Rockenstein, GF Rall, CR Abraham and L Mucke (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice.Nature 367, 188–193.PubMedGoogle Scholar
  209. Toggas SM, E Masliah and L Mucke (1996) Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.Brain Res. 706, 303–307.PubMedGoogle Scholar
  210. Tran PB and RJ Miller (2003) Chemokine receptors: signposts to brain development and disease.Nat. Rev. Neurosci. 4, 444–455.PubMedGoogle Scholar
  211. Turchan J, N Sacktor, V Wojna, K Conant and A Nath (2003) Neuroprotective therapy for HIV dementia.Curr. HIV Res. 1, 373–383.PubMedGoogle Scholar
  212. Verani A and P Lusso (2002) Chemokines as natural HIV antagonists.Curr. Mol. Med. 2, 691–702.PubMedGoogle Scholar
  213. Wang H, S-W Yu, DW Koh, J lew, C Coombs, W Bowers, HJ Federoff, GG Poirier, TM Dawson and VL Dawson (2004) Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death.J. Neurosci. 24, 10963–10973.PubMedGoogle Scholar
  214. Weiss JH and SL Sensi (2000) Ca2+-Zn2+ permeable AMPA or kainate receptors: possible key factors in selective neurodegeneration.Trends Neurosci. 23, 365–371.PubMedGoogle Scholar
  215. Wen TC, Y Sadamoto, J Tanaka, PX Zhu, K Nakata, YJ Ma, R Hata and M Sakanaka (2002) Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression.J. Neurosci. Res. 67, 795–803.PubMedGoogle Scholar
  216. Wesselingh SL, K Takahashi, JD Glass, JC McArthur, JW Griffin and DE Griffin (1997) Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reactionin situ hybridization and immunohistochemistry.J. Neuroimmunol. 74, 1–8.PubMedGoogle Scholar
  217. Wiley CA, V Soontornniyomkij, L Radhakrishnan, E Masliah, J Mellors, SA Hermann, P Dailey and CL Achim (1998) Distribution of brain HIV load in AIDS.Brain Pathol. 8, 277–284.PubMedGoogle Scholar
  218. Yao D, Z Gu, T Nakamura, Z-Q Shi, Y Ma, B Gaston, LA Palmer, EM Rockenstein, Z Zhang, E Masliah, T Uehara and SA Lipton (2004) Nitrosative stress linked to sporadic Parkinson’s disease: S-nitrosylation of parkin regulates it E3 ligase activity.Proc. Natl. Acad. Sci. USA 101, 10810–10814.PubMedGoogle Scholar
  219. Yeh MW, M Kaul, J Zheng, HS Nottet, M Thylin, HE Gendelman and SA Lipton (2000) Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of L-cysteine.J. Immunol. 164, 4265–4270.PubMedGoogle Scholar
  220. Zagury D, A Lachgar, V Chams, LS Fall, J Bernard, JF Zagury, B Bizzini, A Gringeri, E Santagostino, J Rappaport, M Feldman, SJ O’Brien, A Burny and RC Gallo (1998) C-C chemokines, pivotal in protection against HIV type 1 infection.Proc. Natl. Acad. Sci. USA 95, 3857–3861.PubMedGoogle Scholar
  221. Zhang K, GA McQuibban, C Silva, GS Butler, JB Johnston, J Holden, I Clark-Lewis, CM Overall and C Power (2003) HIVinduced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration.Nat. Neurosci. 6, 1064–1071.PubMedGoogle Scholar
  222. Zhang L, T He, A Talal, G Wang, SS Frankel and DD Ho (1998)In vivo distribution of the human immunodeficiency virus/simian immunodeficiency virus coreceptors: CXCR4, CCR3, and CCR5.J. Virol. 72, 5035–5045.PubMedGoogle Scholar
  223. Zhao J, AL Lopez, D Erichsen, S Herek, RL Cotter, NP Curthoys and J Zheng (2004) Mitochondrial glutaminase enhances extracellular glutamate production in HIV-1-infected macrophages: linkage to HIV-1 associated dementia.J. Neurochem. 88, 169–180.PubMedGoogle Scholar
  224. Zheng J, MR Thylin, A Ghorpade, H Xiong, Y Persidsky, R Cotter, D Niemann, M Che, YC Zeng, HA Gelbard, RB Shepard, JM Swartz and HE Gendelman (1999) Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia.J. Neuroimmunol. 98, 185–200.PubMedGoogle Scholar
  225. Zou YR, AH Kottmann, M Kuroda, I Taniuchi and DR Littman (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development.Nature 393, 595–599.PubMedGoogle Scholar

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© Springer 2005

Authors and Affiliations

  1. 1.Center for Neuroscience and Aging ResearchThe Burnham InstituteLa JollaUSA

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